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Ray peat has spoken about the negatives of acetylcholine relating to stress and learning
Acetylcholine is an excitotoxic neurotransmitter
Acetylcholine likely raises serotonin in the brain (preferentially inhibits MAO-A in the brain)
https://pubmed.ncbi.nlm.nih.gov/19025057/
AChE inhibitors...
In Ray's article about learned helplessness, arguably his most important article, one of the main points seems to be that low cholinesterase leads to overexcitation of the nerves and to cell death. He cites articles that show that rats living in idyllic environments have high levels of...
Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
Since there has been a lot of hype about choline lately, I thought I’d bring back some balance to the topic in talking about excessive acetylcholine. Having choline in the diet doesn’t necessarily cause too much acetylcholine but it is something to be aware of. I found this really interesting...
We were discussing choline at page 4 of another thread and we thought it was worthy of its own thread.
According to the National Institutes of HealthTrusted Source, choline is an essential nutrient found in many foods. The brain and nervous system use it to regulate functions that include...
Currently I am experiencing fatigue (mostly in the afternoons, for 5 years), palinopsia (of illusory type: seeing afterimages of high contrast objects, for 2 years), mild anxiety (specially in the morning), waking up around 5:00 with palpitations and buzzing body, tired and hollow eyes after...
Hello, I am experiencing very high serotonin symptoms. I have very low sex drive, brain fog, no drive, I take a dump many times in a day and I have a very white coated tongue at the back of the tongue with cuts. I am sure this is my main problem now, because yesterday I did a test. I reduced my...
I know Ray is against choline supplementation but many nootropics users have had positive experiences with it for improving motivation, memory, and overall cognition.
CDP-Choline breaks down into uridine which has many dopaminergic effects on the body as well. @Hans wrote an article on this...
How often do you still hear that serotonin helps with sleep? Well if someone says that to you again, show them this.
https://men-elite.com/2021/06/17/serotonin-dubs-thee-sleepless/
Yet another blow to the status of the so-called "happiness hormone". While histamine, acetylcholine, and estrogen have long been known as key drivers of asthma the link between the mast cells and the nervous system's production of the vasoconstrictor acetylcholine has remained unknown. The study...
I'm including details here that I've never told anyone/written that much about to my knowledge, but all of it does not need to be read if you're not used to my extremely long, often (arguably) strange posts I make here.
So I was going to post here about it (the pain), but figured it would be a...
Hi all,
Just wanted to share the article that I wrote on OCD: OCD: supplements to help overcome it » MenElite
Please feel free to share what you've tried and what has worked for you.
I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it.
The high acetylcholine syndrome » MenElite
The inflammatory condition, called rheumatoid arthritis or rheumatism, is marked by degeneration and pain in the joints, muscles, and connective tissues. The disease shares many traits with other inflammatory “autoimmune” conditions like multiple sclerosis and lupus, but is especially associated...
Abstract
Tyrosinemia is a rare genetic disease caused by mutations on genes that codify enzymes responsible for tyrosine metabolism. Considering that tyrosinemics patients usually present symptoms associated with central nervous system alterations that ranges from slight decreases in...