• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.


  1. C

    High Acetylcholine = learned helplessness, depression - What are good ways to lower acetylcholine or increase acetylcholinesterase activity?

    Ray peat has spoken about the negatives of acetylcholine relating to stress and learning Acetylcholine is an excitotoxic neurotransmitter Acetylcholine likely raises serotonin in the brain (preferentially inhibits MAO-A in the brain) https://pubmed.ncbi.nlm.nih.gov/19025057/ AChE inhibitors...
  2. Sitaruîm

    Coffee and Cholinesterase (AChE)

    In Ray's article about learned helplessness, arguably his most important article, one of the main points seems to be that low cholinesterase leads to overexcitation of the nerves and to cell death. He cites articles that show that rats living in idyllic environments have high levels of...
  3. NewACC

    Role of Cholinergic and Dopamine Receptors in the Physiology of Caffeine Tolerance

    Dear Forum Members, I found three interesting studies on reversing (or reducing) caffeine tolerance, by adding to chronic (or sub-chronic) caffeine treatment, either the dopamine agonists bromocriptine (a predominantly d2/d3 family agonist) or pergolide (a very potent d1 agonist), or...
  4. InChristAlone

    Acetylcholinesterase info (nightshade sensitivity)

    Since there has been a lot of hype about choline lately, I thought I’d bring back some balance to the topic in talking about excessive acetylcholine. Having choline in the diet doesn’t necessarily cause too much acetylcholine but it is something to be aware of. I found this really interesting...
  5. David PS

    Choline: An Essential Nutrient for Public Health that we’re not getting enough of in our diet

    We were discussing choline at page 4 of another thread and we thought it was worthy of its own thread. According to the National Institutes of HealthTrusted Source, choline is an essential nutrient found in many foods. The brain and nervous system use it to regulate functions that include...
  6. P

    Low acetylcholine? Dysautonomia?

    Currently I am experiencing fatigue (mostly in the afternoons, for 5 years), palinopsia (of illusory type: seeing afterimages of high contrast objects, for 2 years), mild anxiety (specially in the morning), waking up around 5:00 with palpitations and buzzing body, tired and hollow eyes after...
  7. J

    Damaged Gut, High Serotonin, Standard protocols dont work

    Hello, I am experiencing very high serotonin symptoms. I have very low sex drive, brain fog, no drive, I take a dump many times in a day and I have a very white coated tongue at the back of the tongue with cuts. I am sure this is my main problem now, because yesterday I did a test. I reduced my...
  8. RenaissanceMan

    Anti-Peat CDP-Choline enhances cerebral glucose metabolism, increases cerebral blood flow rate & brain ATP, & decreases the accumulation of lactate in the brain

    I know Ray is against choline supplementation but many nootropics users have had positive experiences with it for improving motivation, memory, and overall cognition. CDP-Choline breaks down into uridine which has many dopaminergic effects on the body as well. @Hans wrote an article on this...
  9. Hans

    Serotonin dubs thee sleepless

    How often do you still hear that serotonin helps with sleep? Well if someone says that to you again, show them this. https://men-elite.com/2021/06/17/serotonin-dubs-thee-sleepless/
  10. haidut

    Serotonin (5-HT) is a key driver of asthma

    Yet another blow to the status of the so-called "happiness hormone". While histamine, acetylcholine, and estrogen have long been known as key drivers of asthma the link between the mast cells and the nervous system's production of the vasoconstrictor acetylcholine has remained unknown. The study...
  11. ScurveDream

    Chronic Pain Relieved Greatly By Benadryl/diphenhydramine & Nightmares (story-time)?

    I'm including details here that I've never told anyone/written that much about to my knowledge, but all of it does not need to be read if you're not used to my extremely long, often (arguably) strange posts I make here. So I was going to post here about it (the pain), but figured it would be a...
  12. Hans

    OCD: Supplements To Help Overcome It

    Hi all, Just wanted to share the article that I wrote on OCD: OCD: supplements to help overcome it » MenElite Please feel free to share what you've tried and what has worked for you.
  13. Hans

    The High Acetylcholine Syndrome

    I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it. The high acetylcholine syndrome » MenElite
  14. Diokine

    Role Of Nervous System In Rheumatoid Arthritis – Acetylcholine And TNF-alpha

    The inflammatory condition, called rheumatoid arthritis or rheumatism, is marked by degeneration and pain in the joints, muscles, and connective tissues. The disease shares many traits with other inflammatory “autoimmune” conditions like multiple sclerosis and lupus, but is especially associated...
  15. Hugh Johnson

    L-tyrosine Administration Increases Acetylcholinesterase Activity In Rats

    Abstract Tyrosinemia is a rare genetic disease caused by mutations on genes that codify enzymes responsible for tyrosine metabolism. Considering that tyrosinemics patients usually present symptoms associated with central nervous system alterations that ranges from slight decreases in...