Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice
Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the...
Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens
Chronic stress is a strong diathesis for depression in humans and is used to generate animal models of depression. It commonly leads to several major symptoms of depression, including dysregulated feeding behaviour...
Social touch is important for interpersonal interaction. Gentle touch and slow brushing are typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-tactile (CT) fibers, a class of unmyelinated nerves in the skin. The inability to experience pleasure in...
I decided to try 2mg of Naltrexone yesterday... Yes, I know, this is NOT a low beginner dosage.
Wow, it has completely NUMBED my pleasure response to the following:
-Food literally has no appeal.
-Likes on IG.
Everything about my reward...
I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it.
The high acetylcholine syndrome » MenElite
As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past...
As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as...
I have been suffering from anhedonia (loss of pleasure, no excitement, detachment, etc) I was wondering if bromocriptine or LDN would be useful to experiment with? Any opinions, experiences?