anhedonia

  1. D

    Topical Finasteride Orgasm Issues

    25 Y.O Male, briefly supplemented with topical Finasteride for a month and it has severely reduced orgasm sensation to the point it is almost non existent. In search of anything that can cure this issue.
    • dre97
    • Thread
    • anhedonia male issues orgasm anhedonia sexual dysfunction sexual health
    • Replies: 4
    • Forum: Health
  2. haidut

    Even very low-dose endocrine disruptors induce learned helplessness, anhedonia

    Not much to comment on this study, considering the mountains of literature already available on the topic of endocrine disruptors such as BPA/BPA/DEHP, except to point out that the results were obtained even with very low-dose exposure to the harmful chemicals. Another interesting finding was...
    • haidut
    • Thread
    • anhedonia bpa bps dehp depression dopamine endocrine disruptor feminization learned helplessness
    • Replies: 4
    • Forum: Scientific Studies
  3. haidut

    Dopamine agonists can treat anhedonia

    The title may sound obvious to many, but this study is one of the few to bring up the taboo topic of serotonin's role in symptoms of depression. The current dogma still holds that raising serotonin levels (or activating its receptors) is the most beneficial mechanism to treating depression and...
  4. Lokzo

    Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort

    Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort Amedeo Minichino,1 Matthew A. Jackson,2 Marta Francesconi,3 Claire J. Steves,4 Cristina Menni,4 Philip W. J. Burnet,1 and Belinda R. Lennox1,5 Author...
  5. PeskyPeater

    Semax with Oxiracetam

    Background of experiment: SSRI induced mood apathy and sexual anhedonia every morning intranasal semax 750mcg with 1000mg oxiracetam orally experience with semax intial calming effect, feels kind of down but I think i'm not used to this relaxation of the brain. Not like a nootropic, cannot...
    • PeskyPeater
    • Thread
    • anhedonia apathy nootropic oxiracetam pssd semax ssri
    • Replies: 1
    • Forum: Experiments
  6. PeskyPeater

    SSRI induced serotonin transporter degradation - now reversible

    This is about formula of Chinese medicine that can reverse damage from SSRI and can be used for treating HSP high Sensitive Person with the short allele of serotonin transporter gene. With possible recovery of sexual function or anhedonia. Abstract Ethnopharmacological relevance: Zuojin Pill...
  7. Hans

    Feeling meh? Do this to get rid of apathy!

    Some of us might know that serotonin is involved in mental and emotional suppression and lowering it or increasing the dopamine to serotonin ratio can be very helpful for re-igniting motivation, drive, enjoyment, etc. Feeling meh? Do this to get rid of apathy! Towards the end of the article, I...
  8. username

    After I work out with moderate intensity I sleep very poorly and get very anhedonic, depressed, and anxious. What is my body telling me?

    I will probably post some questions about this again in the future as I am extremely tired, anhedonic, depressed, and feel like I am always on the cusp of a panic attack (though I never actually have one), so I don't know if I can't really flesh this out. I am a male of 29 years. 5'10". 185lb...
    • username
    • Thread
    • anhedonia anxiety depression exercise panic sleep training vital exhaustion
    • Replies: 46
    • Forum: Exercise
  9. Lokzo

    Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice

    Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice Bile acids (BAs) are signaling molecules that are involved in many physiological functions, such as glucose and energy metabolism. These effects are mediated through activation of the...
  10. Lokzo

    Anhedonia Requires Melanocortin Synaptic Adaptations In The Nucleus Accumbens - PUBMED

    Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens Chronic stress is a strong diathesis for depression in humans and is used to generate animal models of depression. It commonly leads to several major symptoms of depression, including dysregulated feeding behaviour...
  11. Lokzo

    Anhedonia to Gentle Touch in Fibromyalgia - PUBMED 2020

    Social touch is important for interpersonal interaction. Gentle touch and slow brushing are typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-tactile (CT) fibers, a class of unmyelinated nerves in the skin. The inability to experience pleasure in...
  12. Lokzo

    Low Dose Naltrexone For Anhedonia/PSSD - WATCH OUT!

    Hey guys, I decided to try 2mg of Naltrexone yesterday... Yes, I know, this is NOT a low beginner dosage. Wow, it has completely NUMBED my pleasure response to the following: -Music. -Exercise high. -Sex. -Sweet foods. -Food literally has no appeal. -Likes on IG. Everything about my reward...
    • Lokzo
    • Thread
    • anhedonia mood naltrexone pssd
    • Replies: 5
    • Forum: Experiments
  13. Hans

    The High Acetylcholine Syndrome

    I wrote an article on acetylcholine which describes symptoms of high and low acetylcholine. I also discuss what can cause it to be high or low and what supplements can be used to block or boost it. The high acetylcholine syndrome » MenElite
    • Hans
    • Thread
    • acetylcholine anhedonia anxiety crying depersonalization depression low heart rate ocd overly emotional sweating
    • Replies: 64
    • Forum: Articles & Scientific Studies
  14. haidut

    Serotonin Causes Anhedonia. And Mental Illness In General

    As many of my readers know, anhedonia is one of the most pernicious symptoms of most mental disorders, and is perhaps the most resistant to therapy. It also happens to be one of the main triggers of attempted suicide, based on interviews with suicide survivors. I posted some threads in the past...
    • haidut
    • Thread
    • anhedonia cause chronic stress depression mental illness serotonin social defeat stress tph
    • Replies: 2
    • Forum: Scientific Studies
  15. haidut

    Endotoxin (LPS) May Cause Depression / Anhedonia

    As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as...
    • haidut
    • Thread
    • anhedonia cause depression endotoxin inflammation lps tlr tlr4
    • Replies: 31
    • Forum: Scientific Studies
  16. 0

    Low Dose Naltrexone Vs Bromocriptine [Anhedonia]

    Hi Everyone, I have been suffering from anhedonia (loss of pleasure, no excitement, detachment, etc) I was wondering if bromocriptine or LDN would be useful to experiment with? Any opinions, experiences?
    • 032487
    • Thread
    • anhedonia bromocriptine low dose naltrexone naltrexone pharmaceutical drugs
    • Replies: 19
    • Forum: Pharmaceutical Drugs
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