Skin Aging pivotal to hair loss and skin immunity? TGFb1 player

[GorillaHead]

TGF-β is Involved in the Loss of Fat and Bacterial Defenses in Aging Skin

TGF-β is a problematic protein that is involved in the regulation of chronic inflammation and many other processes important in aging. Unfortunately, presently available means of suppressing TGF-β activity have potentially serious side-effects, as TGF-β has important functional roles in many...

www.fightaging.org

READ the comments as well and referenced papers.

This study seems to imply some big things, it seems that tgfb1 is increased in aging skin and this has been found to be an inhibitor of hair growth when uopreguialted too much but whats most interesting is the fact that in hairloss cases Sebboreic Dermatitis seems to be correlated with MPB hair loss.



The study implies aging skin caused by too much tgfb1 and that too much tgfb1 leads to loss of skin immunity!

This might be the big puzzle for the dandruff so many of us experience and the hair loss that comes with it in most peoples cases.
In both asthma and MPB and aging skin tgfb1 overly expressed and PGD2 is increased in at least two of these cases.

I had one theory that hypoxia leads to increased skin desquamation and that hypoxia would be caused by weaker blood flow and nutrition, So what would be key is focusing on ENOS. Honestly this truly may be that simple that’s subucanteous vascularity is key to so many diseases.




Besides herbal treatments it might be wise to look into what limits and controls tgfb1 expression in skin as we age on a core nutritional profile.

I found vitamin D to be one of them so this may definitely be Crucial to slowing down aging, but there is likely other core nutrient or minerals at play.

 

[SamYo123]

Dietary fiber enhances TGF-β signaling and growth inhibition in the gut

Dietary fiber intake links to decreased risk of colorectal cancers. The underlying mechanisms remain unclear. Recently, we found that butyrate, a short-chain fatty acid produced in gut by bacterial fermentation of dietary fiber, enhances TGF-β ...

www.ncbi.nlm.nih.gov

 

[golder]

Great find Gorilla. It would be useful to collate some smart minds from the forum with ways to lower TGFB1 and PGD2.

 

[golder]

Pregnenolone increases it? Wasn’t expecting that:

 

[Rafael Henrique]

Potential inhibitors of TGF B-1:

- Sun/UV [L, L]

- Curcumin [L]

- Black cumin seed oil [L]

- Extra virgin olive oil [L]

- Berberine [L]

- Grape seed extract

- Ginkgo [L]

- Zinc

- Garlic

- Ginseng [L]

- stop smoking if you do [L]

- reduce psychological stress [L, L, L, L]

From a website*