Sirtuins And Life Extension


Mar 18, 2013
USA / Europe
Hi all,

In the last couple of years there has been a lot of "noise" in the media about how the SIRT-family of genes can extend lifespan when activated by things like exercise or, preferably, by certain chemical compounds like resveratrol (which putatively acts on SIRT-1). Ray Peat has stated his opinion that activating those genes is not likely to lead to life extension and may even be implicated in some cancers. In one is his articles he talks about how niacinamice/nicotinamide (vitamin B3) acts in a way approximately opposite to resveratrol. Also, there are independent studies that found niacinamide silences SIRT-1 and SIRT-2 in high doses. An interesting study came out recently that seems to corroborate Ray's views. It looks like it's niacinamide that actually extends life while resveratrol so far has been a bust (several clinical trials halted due to resveratrol increasing mortality in patients). The sirtuins putative life extension (if any) seems to be due to their ability to convert niacinamide into NAD+ and MNA. Here is the study for those interested: ... .1352.html

Morale of the story - ditch the resveratrol if you are currently taking it, and switch to its antagonist niacinamide.


The Law & Order Admin
Jan 4, 2012
[glow=red]Ray Peat right again![/glow]​


Nov 30, 2012
Keep in mind we Peatians think Peat is right while most people don't. People are going to continue using resveratrol, fish oil and smearing argan oil on their skin.

SIRT1, what can it be compared to..... it kind of has that "space age" sound and feeling to it. The media has dubbed it the "skinny gene"........

SIRT1, how to be slow and age!
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