1. H

    Does the methylation of Methyl Salicylate have similar duration properties as methylated saturated fats?

    A friend that's in Guyana right now told me about Shiling Oil and how good it makes him feel when applied topically. Here's a listing for it online: Shiling Oil External Analgesic (28ml). It looks like it has ingredients I'd rather go without like Eucalyptus oil but imagine that Methyl...
  2. B

    Best Methylation Supplement for People Sensitive to Methylfolate?

    I found out I was MTHFR +/+ and had high homocysteine levels. I tried taking doses of TMG and methylfolate and would flip out from overstimulation. As Dr. Masterjohn explains it, it was like the neurological equivalent of someone "shouting in my ear with a bullhorn" after being used to a...
  3. A

    Need help to figure out why I react so badly to coffee

    Firstly, I have PSSD but not prefer to call it that way because my problems are more akin to CFS/progressive dementia. Whenever I drink coffee, my dementia goes worse (vision, cognitive abilities), my bowel gets more reactive to inner stimuli, my chronic hunger problem gets worse, my motor...
  4. A

    Methyl Group, Methylation, Methyl Trapping: What Are They?

    Methyl group: Carbon + 3 hydrogens (CH3) Methyl donor: a substance that is capable of donating a methyl group to another compound. Simply because something has a ‘methyl group’ does not mean it can donate it. Methylation: The act of giving a methyl group to another compound altering its...
  5. mayku-T-meelo

    Ray Peat Interview KMUD - Apr 16, 2021

    Just in case.
  6. Recoen

    Elliot Overton On TTFD And Methylation

    Get extreme anxiety or depression from TTFD supplementation? You should read on: Did you know that TTFD uses up SAM-e, and therefore can be taxing on methylation? I recently had a male client who explained that TTFD therapy initially produced great increases in mental clarity, energy, and...
  7. haidut

    Simple Metabolic Change Sufficient To Turn "normal" Cells Into "cancer"

    Yet another study exposing the fraud/myth that somehow "cancer" cells are different and evil and as such the only hope for curing cancer is killing them before they kill their "host". The central dogma of oncology is that genetic mutations happen first (and randomly so). Then, once a "cancerous"...
  8. haidut

    Parents’ Emotional Trauma May Change Their Children’s Biology

    Not a new idea, but the study is a nice summary of recent work in the area and demonstrates that the old gene-centric idea of inheritance is slowly being replaced by a much richer theory of how organisms interact with their environment and how they pass this information down to generations. It...
  9. haidut

    Familial Breast Cancer Is Mainly Driven By Methylation, Not Genes

    I think this is a very important study because it shakes the foundations of one of the most solid cases cited by mainstream oncology in favor of cancer begin driven by genes. Familial breast cancer, purportedly linked to the infamous (and patented) genes BRCA1 and BRCA2, is thought to be one of...
  10. haidut

    Cells Have Memory, And Memories Of Past Conditions Affect Future Response

    This study looks at a concept that Peat has written a lot about and which has been largely ignored by mainstream medicine (in favor of genetic explanations) - epigenetic cell memory. The study only looked at muscle cells but there is no reason to believe the same mechanism is not present in...
  11. Drareg

    High Cortisol In 5-year-old Children Causes Loss Of DNA Methylation In SINE Retrotransposons: A

    Whats interesting here is it's showing cortisol demethylating dna? Lowering cortisol in certain circumstance might not be ideal? High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases "Childhood stress...
  12. P

    Does Methylene Blue Increase Methylation?

    Hello! I wonder if anyone knows if methylthioninium chloride (A.K.A methylene blue) increases methylation, and if so, at what dosages it would exert that effect. I read someone claiming methylene blue donates methyl groups and increases methylation, that's why I would like to have some...
  13. S

    Theobromine Experiences

    Has anyone tried this? Is it longer or shorter than caffeine? Also, do you think the methyl groups can become a problem with xanthines over time?
  14. haidut

    Poverty Causes Depression By Increasing Serotonin Activity

    The conditions of learned helplessness and PTSD have many features in common and both of them have been linked to dysfunction of the monoaminergic system. There has been a lot of research over the last decade tying adverse life conditions in childhood to mood and memory problems as an adult...
  15. S

    Bullied Twins, Serotonin, Blunted Response to Stress

    Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Bullied twins had higher SERT DNA methylation at the age of 10 years compared with...
  16. haidut

    Methylation Tied To Cancer (again)

    Ray has written about this and I have also posted studies in the past. I have noticed that in the last couple of years the message has been getting stronger - i.e. methylation is a big factor in cancer. Hopefully, the field will move away from the completely genetic explanation of cancer as more...
  17. Hugh Johnson

    Lidocaine Demethylates DNA

    Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro I wonder if chronic oral intake could reverse gene methylation.
  18. haidut

    Methylation Levels Can Predict Breast Cancer Risk

    Related to my post on the BRCA genes and breast cancer risk, this study found out that overmethylation of certain genes associated with stem cell differentiation predicts breast cancer risk across the board and not just for women with faulty BRCA1 gene. In simpler words - Ray Peat seems to be...
  19. C

    Choline, Folate Vs Folic Acid

    From the Perfect Health Diet, chapter 35: Choline and Folic Acid - Both choline and folic acid are important for brain and neurological function, lipid metabolism, DNA health. - Choline is deficient in most people, and folic acid (which doesn't occur in nature) has reached extremely high...
  20. haidut

    DNA Methylation, Aging, And Cancer

    Hi all, Ray Peat has talked about this in some of his articles, and mentioned some specific techniques one can use to combat aging. This article talks about the relationship between the levels of methylation, aging, and cancer. As you suspect, with time methylation increases the risk of...
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