sirtuins

  1. haidut

    Niacinamide May Treat Brain Cancer (glioblastoma)

    Neuroblastoma is one of the most common brain cancers and one of the most lethal ones of all cancers. Senator John McCain is probably the most famous recent victims of this cancer, and others famous cases include Senator Ted Kennedy and one of Joe Biden's son. The latter two died from the cancer...
  2. haidut

    HDAC Inhibitors Affect Every Function Of The Cell And May Extend Lifespan

    The use of HDAC inhibitors such as valproic acid or various butyrate salts for cancer treatment has been studied experimentally for decades. Until now, it was assumed that the process of histone acetylation and deacetylation affected mostly the processes associated with cell division and...
  3. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
  4. haidut

    Niacinamide Is Anti-estrogenic

    Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...
  5. E

    Niacinamide Inhibits Sirtuins. Reason To Not Take Niacinamide?

    Nicotinamide (aka niacinamide) may be a potent promoter of aging. Please see #5 in the following article which also mentions other issues with niacinamide...
  6. haidut

    Niacinamide Lowers Fatty Acid Oxidation By Inhibiting SIRT1

    Many of you have probably heard of the resveratrol "miracle pill", which works by activating the SIRT1 "longevity gene". Well, the whole story is a classic example of medical fraud, and resveratrol was a miserable failure in clinical trials. This is not surprising to me as resveratrol has...
  7. haidut

    Sirtuins And Life Extension

    Hi all, In the last couple of years there has been a lot of "noise" in the media about how the SIRT-family of genes can extend lifespan when activated by things like exercise or, preferably, by certain chemical compounds like resveratrol (which putatively acts on SIRT-1). Ray Peat has stated...
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