Optimal Diet For Increasing Lifespan

[tara]

What are some commonalities among long-lived populations, for those familiar with them?
Slight caloric restriction?
Moderate protein?
Move frequently at slow pace?
Simple lifestyle?
Respect for the Circadian rhythm?
A natural, non-industrialized diet?
Low environmental stressors?

I don't have a wide perspective on this, but remember reading of a study that showed significant lifespan differences between geographically close valleys in China with similar culture and diet habits, climate, etc, but much higher mineral levels, esp calcium, in the natural water sources that the longer-lived population were drinking and irrigating crops with, because of different rock composition in the watershed.

 

[Amazoniac]

I still insist (and I can be wrong) in the fact that mantaining a sustainable metabolism in warmer climates is much easier and less stressful, also requires less effort in my opinion that may contribute to longer life span.

Ps.: I once have been to Ecuador and, contrary to our common belief, the climate is considerably cold. To the point of being able to see snow at the horizon, at the mountains/volcanos (Google Cotopaxi for images). So, just as a reminder, being near the Equator doesn't automatically equals warm climate.
It has some cold cities due to the their elevation. Maybe not for a Norwegian standard but still cold for the majority.

 

[Amazoniac]

Forgot to add that is not uncommon to find long lived populations tied to poverty, scarcity or at least some period of famine..
Dairy is so convenient in those cases because it offers nutrient density at relatively low cost and effort.

 

[aquaman]

Study healthy centenarians in any "blue zone" and you are likely to find that they generate far more CO2 than you would expect. I think the imprinting of family and friends upon centenarians throughout their lives has allowed them to enjoy the increased CO2 of uncoupled respiration, and hence, to enjoy life.

You make some big leaps in logic sometimes Vos!!!!

 

[pboy]

ease of all flow movements and actions, and a careful attention, intimately, to the body and rythmns. Eating patterns and sleep are huge...finishing eating before dark, good sleep, and waking up early are all huge factors...the biggest thing is desire to be alive, so you have to feel like you are wanted and valuable (why in small communities who respect elders...they live longer) and have to be enjoying yourself with a sense of ease and wonder, and no fear of the beyond. You can be really intense and take things to the limit, extreme, but it must be done lightly and in a fun way without aggression or frustration

 

[visionofstrength]

Study healthy centenarians in any "blue zone" and you are likely to find that they generate far more CO2 than you would expect. I think the imprinting of family and friends upon centenarians throughout their lives has allowed them to enjoy the increased CO2 of uncoupled respiration, and hence, to enjoy life.

You make some big leaps in logic sometimes Vos!!!!

I hear you. But look, Peat has said that he watches TV while sitting in a bag of CO2. He's also said that Charles Darwin's father Erasmus held Lamarckian views about imprinting, and that Charles Darwin did, too, until Charles was pressured to adopt the "survival of the fittest" view that was being imposed on him politically at the time.

Please consider that the real "leap" here may be how far backward medicine and science have come since the time of Darwin, when carbon dioxide therapy was already well-accepted and even prevalent.

Sure, uncoupled respiration is a new physical description, but it may simply describe what the yogis living high in the mountains have been doing for thousands of years, yogis who may have lived some of the longest lives in history.

For example, there's anecdotal evidence of this even now: In a Himalayan valley 2,000 metres above sea level and cut off from the rest of the country for almost six months because of the snow -- where only 60 percent of the region's population has even been added to federal data -- each village in that valley has a dozen or so people in their nineties or hundreds.
http://www.huffingtonpost.ca/2014/08/11 ... thy+Living

If you feel like you trust modern data (caveat: which I don't), a study claimed to show 7 of the top 10 counties in the U.S. for longevity were high-altitude counties in Colorado, with an average life span of 81.3 years.
http://articles.chicagotribune.com/2011 ... ng-disease

Altitude and CO2 have also been linked to the absence of obesity or heart disease. One of the biggest challenges in climbing Everest is keeping up with the enormous consumption of calories that occurs at high altitude.

Takeaway: using CO2 therapy whenever you can is the most inexpensive and practical way to emulate the effects of high altitude, which may include living longer, and being thinner and healthier.

 

[Such_Saturation]

Study healthy centenarians in any "blue zone" and you are likely to find that they generate far more CO2 than you would expect. I think the imprinting of family and friends upon centenarians throughout their lives has allowed them to enjoy the increased CO2 of uncoupled respiration, and hence, to enjoy life.

You make some big leaps in logic sometimes Vos!!!!

I hear you. But look, Peat has said that he watches TV while sitting in a bag of CO2. He's also said that Charles Darwin's father Erasmus held Lamarckian views about imprinting, and that Charles Darwin did, too, until Charles was pressured to adopt the "survival of the fittest" view that was being imposed on him politically at the time.

Please consider that the real "leap" here may be how far backward medicine and science have come since the time of Darwin, when carbon dioxide therapy was already well-accepted and even prevalent.

Sure, uncoupled respiration is a new physical description, but it may simply describe what the yogis living high in the mountains have been doing for thousands of years, yogis who may have lived some of the longest lives in history.

For example, there's anecdotal evidence of this even now: In a Himalayan valley 2,000 metres above sea level and cut off from the rest of the country for almost six months because of the snow -- where only 60 percent of the region's population have even been added to federal data -- each village in that valley has a dozen or so people in their nineties or hundreds.
http://www.huffingtonpost.ca/2014/08/11 ... thy+Living

If you feel like you trust modern data (caveat: which I don't), a study claimed to show 7 of the top 10 counties in the U.S. for longevity were high-altitude counties in Colorado, with an average life span of 81.3 years, according to a study.
http://articles.chicagotribune.com/2011 ... ng-disease

Altitude and CO2 have also been linked to the absence of obesity or heart disease. One of the biggest challenges in climbing Everest is keeping up with the enormous consumption of calories that occurs at high altitude.

Takeaway: using CO2 therapy whenever you can is the most inexpensive and practical way to emulate the effects of altitude: living longer, and being thinner and healthier.

This is for cancer. It's like a topographic map almost.

 

[visionofstrength]

What are some commonalities among long-lived populations, for those familiar with them?
Slight caloric restriction?
Moderate protein?
Move frequently at slow pace?
Simple lifestyle?
Respect for the Circadian rhythm?
A natural, non-industrialized diet?
Low environmental stressors?

Choosing commonalities after you already have a data set is called "cherry-picking". So for example, centenarians tend to sleep longer. But why? Or is it a random coincidence?

Even if you did a chi-squared test of what the chances are of a commonality being random, and you found that it was unlikely to be random, then what?

The beauty of Peat's carbon dioxide theory is that it can explain all these commonalities at once, with great simplicity. Does the proposed commonality (such as thyroid, milk and sugar, saturated fat, raw carrot, or even longer sleep) increase CO2 level? Then it may be worth doing assuming that it's practical (and inexpensive).

 

[Such_Saturation]

Stroke data:

Interesting comparison with black population fraction, who might have higher estradiol [http://www.ncbi.nlm.nih.gov/pubmed/17456570]:

 

[Jennifer]

Such_Saturation, the first map shown, is it the darkest red that's the highest mortality rate for cancer?

 

[Such_Saturation]

Such_Saturation, the first map shown, is it the darkest red that's the highest mortality rate for cancer?

Yes. Cancer incidence is similar.

 

[Such_Saturation]

Suikerbuik!

 

[Amazoniac]

http://en.wikipedia.org/wiki/Hara_hachi_bu

 

[Amazoniac]

About CR without malnutrition and the adaptations of restricting methionine and cysteine increasing Hydrogen Sulfide.
http://www.cell.com/cell/pdf/S0092-8674(14)01525-6.pdf
http://www.pnas.org/content/104/46/17907.full.pdf
http://www.ncbi.nlm.nih.gov/pmc/article ... q17977.pdf

 

[Koveras]

4) Increasing carbs:protein ratio did lead to symptoms of fatty liver and increased weight, but SURPRISINGLY these effects were protective and in old age the overweight and fatty liver phenotype mouse was also the healthiest and longest living. So, another point for Peat and many others studying the so-called "obesity paradox" pointing out that being lean (as measured by BMI) in old age is NOT good for you.

More evidence that a fatty liver can be protective in some instances

"Mice in the FF diet group received a diet that was relatively rich in saturated fats, cholesterol, and fructose and provided 41% energy from fat (milk fat, 12% saturated), with 0.2% cholesterol (D12079B, Western diet, Research Diet, New Brunswick, NJ). "

BMC Gastroenterol. 2017 Nov 28;17(1):124. doi: 10.1186/s12876-017-0680-z.
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.
Kim TH1, Choi D2, Kim JY3, Lee JH3, Koo SH4.
BACKGROUND:
Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induced ALI. Non-alcoholic fatty liver disease (NAFLD), the major cause of chronic liver disease, is considered an important predictor of APAP-induced ALI, although the exact mechanism controversial. In this study, we aimed to elucidate the effects of NAFLD on APAP-induced ALI.
METHODS:
Two groups of mice, normal chow (NC) diet-fed and fast food (FF) diet-fed mice for 14 weeks, were further divided into two subgroups: intraperitoneally injected with either saline (NC-S and FF-S groups) or APAP (NC-A and FF-A groups). Biochemical tests, histological analysis, quantitative PCR, and western blotting were conducted.
RESULTS:
Alanine aminotransferase (ALT) level (199.0 ± 39.0 vs. 63.8 ± 7.4 IU/L, p < 0.05) and NAFLD activity score (0 vs. 4.5 ± 0.22) were significantly higher in mice in FF-S group than those in NC-S group. ALI features such as ALT level (8447.8 ± 1185.3 vs. 836.6 ± 185.1 IU/L, p < 0.001) and centrizonal necrosis were prominent and mRNA levels of Trib3 (RR, 1.81) was high in mice in the NC-A group. Levels of CYP2E1 and anti-inflammatory molecules such as PPAR-γ, p62, and NRF2 were high in mice in the FF-A group.
CONCLUSIONS:
Our results showed that while the FF diet clearly induced non-alcoholic steatohepatitis and metabolic syndrome, NAFLD also attenuates APAP-induced ALI by inducing anti-inflammatory molecules such as PPAR-γ.

 

[haidut]

More evidence that a fatty liver can be protective in some instances

"Mice in the FF diet group received a diet that was relatively rich in saturated fats, cholesterol, and fructose and provided 41% energy from fat (milk fat, 12% saturated), with 0.2% cholesterol (D12079B, Western diet, Research Diet, New Brunswick, NJ). "

BMC Gastroenterol. 2017 Nov 28;17(1):124. doi: 10.1186/s12876-017-0680-z.
Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.
Kim TH1, Choi D2, Kim JY3, Lee JH3, Koo SH4.
BACKGROUND:
Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induced ALI. Non-alcoholic fatty liver disease (NAFLD), the major cause of chronic liver disease, is considered an important predictor of APAP-induced ALI, although the exact mechanism controversial. In this study, we aimed to elucidate the effects of NAFLD on APAP-induced ALI.
METHODS:
Two groups of mice, normal chow (NC) diet-fed and fast food (FF) diet-fed mice for 14 weeks, were further divided into two subgroups: intraperitoneally injected with either saline (NC-S and FF-S groups) or APAP (NC-A and FF-A groups). Biochemical tests, histological analysis, quantitative PCR, and western blotting were conducted.
RESULTS:
Alanine aminotransferase (ALT) level (199.0 ± 39.0 vs. 63.8 ± 7.4 IU/L, p < 0.05) and NAFLD activity score (0 vs. 4.5 ± 0.22) were significantly higher in mice in FF-S group than those in NC-S group. ALI features such as ALT level (8447.8 ± 1185.3 vs. 836.6 ± 185.1 IU/L, p < 0.001) and centrizonal necrosis were prominent and mRNA levels of Trib3 (RR, 1.81) was high in mice in the NC-A group. Levels of CYP2E1 and anti-inflammatory molecules such as PPAR-γ, p62, and NRF2 were high in mice in the FF-A group.
CONCLUSIONS:
Our results showed that while the FF diet clearly induced non-alcoholic steatohepatitis and metabolic syndrome, NAFLD also attenuates APAP-induced ALI by inducing anti-inflammatory molecules such as PPAR-γ.

Thanks. I think SFA also reduce cellular uptake of drugs like acetaminophen. Adamantane drugs like amantadine and memantine have also been shown to protect from liver toxicity due to acetaminophen and they act similar to SFA in blocking uptake of certain chemicals and metabolic poisons.

 

[Sefton10]

New study from Oct 2022​

Dietary restriction fails to extend life in stressful environments​

“Our results challenge the long-held idea that extended longevity of diet-restricted laboratory animals represents an adaptive survival strategy in natural populations, and suggest instead that this response is an artefact of benign laboratory conditions.”

Dietary restriction fails to extend life in stressful environments

Moderate dietary restriction often prolongs life in laboratory animals, and this response has been interpreted as an adaptive strategy that promotes survival during famine. However, dietary restriction can also increase frailty, and it therefore remains unclear whether restricted diets prolong...

www.biorxiv.org