Niacinamide Lowers Fatty Acid Oxidation By Inhibiting SIRT1

[Hugh Johnson]

If the body is cranking along well and metabolism is good (health), running glucose low in the absence of nicotinamide might not be such a bad thing once in a while in order to deplete stored PUFAs. (Making hay while the sun shines.) Because, in the event of sickness, when stress is already elevated, and added burdens are not easily born, a fever can rapidly deplete glucose leading to the generation of stress hormones and the use of fatty acids for energy. PUFAs then enter the blood and mitochondrial metabolism exactly when the system is weakest, further increasing stress. A downward spiral.

Fatty acids are constantly released and absorbed by fat cells. It's better not to do unnecessary stressors and just let the live take out PUFA as they come out naturally. And of course eat coconut oitl to protect from that PUFA until you are deficient.