ken
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- Joined
- Oct 31, 2012
- Messages
- 288
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ken said:
ken said:post 100881 They tried aspirin."Pharmacokinetically, SSA is quickly metabolized into its active component, salicylate. Unlike salicylate, aspirin (acetylsalicylate) leads to higher levels of ac-tau in cultured neurons. SSA and aspirin have been widely used to treat rheumatoid arthritis and related illnesses in the past decades, and work presumably via inhibition of cyclo-oxygenase (COX). Interestingly, patients taking NSAIDs, including salicylate and derivatives, have a reduced risk of AD."
Giraffe said:post 100947 "We identified for the first time a pharmacological approach that reverses all aspects of tau toxicity," says co-senior author Li Gan, PhD, an associate investigator at the Gladstone Institutes. "Remarkably, the profound protective effects of salsalate were achieved even though it was administered after disease onset, indicating that it may be an effective treatment option." Although tau has been a target in dementia research for some time, there are no tau-targeted drugs available for pati
Thanks for the clarification. I read it, but I did not understand it. I don't know what "tau pathology" is.haidut said:post 100954 Did you see my post above with the quote from the study? I think it is pretty clear in what it says - i.e. salicylic acid can reverse all aspects of Alzheimer and works even when the disease is already well established.
Giraffe said:post 100957Thanks for the clarification. I read it, but I did not understand it. I don't know what "tau pathology" is.haidut said:post 100954 Did you see my post above with the quote from the study? I think it is pretty clear in what it says - i.e. salicylic acid can reverse all aspects of Alzheimer and works even when the disease is already well established.
Three aspirin (500 mg each) is the dose for a 60 kg person (female, 75 years, advanced Alzheimer's disease)?
ken said:post 101186 Also the salsalate seemed a whole order of magnitude more expensive on the internet. Maybe they want to make a legacy drug out of it.
haidut said:post 101216ken said:post 101186 Also the salsalate seemed a whole order of magnitude more expensive on the internet. Maybe they want to make a legacy drug out of it.
That is my guess. The scientists have gone silent over my email about aspirin and how in IN VIVO it is indistinguishable from salsalate. I will keep bugging them but it is pretty clear that they don't want to answer.
haidut said:post 101301
So, I think you can spread the word far and wide - aspirin cures Alzheimer disease (AD)!