High Dose Niacin (6g/day) Reduces Hypercholesterolemia By 20% Or More

burtlancast

Member
Joined
Jan 1, 2013
Messages
3,263
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=0ahUKEwjZ95bLoebdAhXELFAKHZD4BvQQgAMIKygA&url=http://scholar.google.ro/scholar_url?url=https://www.cabdirect.org/cabdirect/abstract/19621401059&hl=en&sa=X&scisig=AAGBfm04ziTCGB_8HPvZqazFrX-ueQzW6A&nossl=1&oi=scholarr&usg=AOvVaw0ofJw9ka4tuaPKooQMwMea

Nicotinic acid therapy in patients with coronary disease

This is a hyper suppressed 1960 article from New Zaeland were investigators fed 35 hypercholesterolemic patients 3 to 6g of niacin/day for up to 1.5 years with excellent lipid lowering results and manageable side effects.

It mentions too the regimen had dramatic preventive effects on angina patients.

Not a very good article for the Statins industry.

Does anyone know how to get the entire article ?

Of 35 patients, 33 male and 2 female, with coronary disorder treated with nicotinic acid, 25 had been followed for 3 to 18 months. About half were already being treated with the anticoagulant phenindione. All were regarded as being clinically in a steady state. Nicotinic acid was given as Pelonin (Glaxo, N.Z.) 3 times daily after food, at first in doses of 500 mg, rapidly increased to 1000. Plasma cholesterol was estimated by the method of Zlatkis et al. (Abst. 3890, Vol. 23), modified.
Initial values ranged from 241 to 504 mg per 100 ml. Values fell in all the patients, in the 25 followed for at least 3 months by between 7 and 46% of the initial value. The maximum effect was usually reached within 2 months, and that value was subsequently maintained with fluctuations. On withdrawal of treatment from 15 of the patients the initial value was re-established within from 1 to 3 weeks. Angina of effort, when present, was relieved in most patients, strikingly so in some [relevant column headings in Table IV appear to be reversed]. No patient had high blood pressure and no effect on blood pressure was observed. Most patients had flushing, pruritus and prickling of the skin, but they were bearable. Gastrointestinal disturbance caused cessation of treatment in 8. of the original 35 patients; others had intermittent mild dyspepsia.-E. M. Hume.
 
Last edited:

Similar threads

Back
Top Bottom