Alzheimers And T3,Rt3

Drareg

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Ray Peat has written and spoken about Alzheimers and dementia in general.

These studies are small but very interesting, I don't understand why they don't check T3 and reverse T3 for Alzheimers.This is all I can find at the moment.

Study showing T3 is low in Alzheimers patients .

Low Levels of Triiodothyronine in Patients with Alzheimer’s Disease

This shows reverse T3 is high in spinal fluid.

Increased cerebrospinal fluid levels of 3,3',5'-triiodothyronine in patients with Alzheimer's disease. - PubMed - NCBI

Hypothalamic pituitary thyroid access in patients with Alzheimer's. They conclude its an issue. I'm not sure what's low so if anyone can help .....

Hypothalamic-pituitary-thyroid axis in patients with Alzheimer disease (AD). - PubMed - NCBI

Showing T3 influenced epigentics events on amyloid precursor protein.
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. - PubMed - NCBI

Possible Conversion issues T4 to T3.
Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients. - PubMed - NCBI

study pointing to high Rt3.
Thyroid hormones, dementia, and atrophy of the medial temporal lobe. - PubMed - NCBI

Study in Down syndrome patients showing lower T3 present in patients with Alzheimer's.
Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down syndrome: a comparison of patients with and without ma... - PubMed - NCBI

T3 levels are low.
Thyroid status in senile dementia of the Alzheimer type (SDAT). - PubMed - NCBI

Does anybody have any experience with their doctor measuring T3 and Rt3 in the early blood tests when Alzheimers is suspected?
In saying the above they give potent ssri's for Alzheimers without checking serotonin when doing bloods.
 

narouz

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In my experience (with my dad--dementia), they don't do sheet in this regard.
And it is a memory specialist I'm thinking of here.

Very interesting, Drareg.
Thanks!
 

Drareg

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In my experience (with my dad--dementia), they don't do sheet in this regard.
And it is a memory specialist I'm thinking of here.

Very interesting, Drareg.
Thanks!

I think Peat prefers progesterone as a start rather than t3 because it might be to much to soon, if however the bloods point to issues with rt3 and t3 it should be a reasonable way forward.

Speculating here-
The thing is most patients are getting 3 different kinds of potent ssri's, these could be having effect by indirectly increasing allopregnenolone, if this is the case adding progesterone could cause more allopregnenolone which has been shown to cause aggressive symptoms, this will scare people away from progesterone, it seems you need to get the ssri's out of the system first,some of these have potent anti-psychotic effects,renders the patient helpless but more manageable which some families prefer because of the wandering and aggression without treatment.

On top of the above they are getting a statin, patch for stopping the breakdown of choline and in some cases blood pressure meds, some complain of cramps so they throw in quinine.
Cholesterol is being inhibited so when allopregnenolone can't be formed at this point the rapid deteriation may begin,progressive freezing as Peat mentions.
When choline isn't working they give out memantine but still keep the choline patch.

We removed the patch and seen a slight improvement, when they went back to the consultant he said nothing about it even though he noted improvements in movement, it was at this point he added a third ssri, I got the family to ask about serotonin, why give it without measuring bloods, they recorded his response, he said we just don't normally do it,it was in front of med students. He said the same thing about measuring progesterone,we just don't do it, we don't know what levels they should be at with elderly people.

Thiamine has shown a slight improvement at 100g for said lady,after a nights sleep she recognised a few old photographs, I'm curious about allithiamine in this case being fat soluble an all. This lady has a preferred taste for glucose/fructose.
Vitamin E made slight improvement but initially I noticed a touch of pallor and slight restlessness, the next morning their was healthy colour in face and mood, initially I would guess slightly inhibiting the fatty acid metabolism causes a slight change,same with niacinamide, their metabolism seems to be inclined to veer down those pathways, I'm thinking thiamine,t3 are better because they just help glucose, I don't thing they inhibit fat metabolism as strongly as the other 2.

Hydergine was used to treat dementia in the past,some research on Hydergine can't be read on pubmed but the study title is there, hydergine is rumoured to have similar capacity to T3.

Have you had any success ?
 

narouz

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I got my dad off the statin a couple years ago,
and he's not getting any other meds for his dementia.
His TSH was little high so I started giving him a bit of NDT.
I haven't checked his other thyroid levels, but you mentioning it makes me want to do so.

He's doing a fairly Peatish diet and many Peatish supplements, vitamins, minerals.
Main Peat supplement I'm giving him now is aspirin.
He's up to 5- 325mg pills/day. haidut has posted some excellent stuff on dementia and aspirin if you haven't seen it.
Have to give him big doses of K1, K2-4, K2-7 while on that much aspirin
to keep him from getting "bruise" marks all over his arms.

I had tried Methylene Blue for a while, and will return to that I think,
although not sure at what dose.

Giving him about 100mg pregnenolone/day and a lot of thiamine and biotin.
Also magnesium and calcium.
Coconut oil, but problematic because it upsets his stomach.

I also want to get lamps set up to give him some big doses of red light,
especially directed at his head.

I will have to look into Hydergine!
 

Drareg

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I got my dad off the statin a couple years ago,
and he's not getting any other meds for his dementia.
His TSH was little high so I started giving him a bit of NDT.
I haven't checked his other thyroid levels, but you mentioning it makes me want to do so.

He's doing a fairly Peatish diet and many Peatish supplements, vitamins, minerals.
Main Peat supplement I'm giving him now is aspirin.
He's up to 5- 325mg pills/day. haidut has posted some excellent stuff on dementia and aspirin if you haven't seen it.
Have to give him big doses of K1, K2-4, K2-7 while on that much aspirin
to keep him from getting "bruise" marks all over his arms.

I had tried Methylene Blue for a while, and will return to that I think,
although not sure at what dose.

Giving him about 100mg pregnenolone/day and a lot of thiamine and biotin.
Also magnesium and calcium.
Coconut oil, but problematic because it upsets his stomach.

I also want to get lamps set up to give him some big doses of red light,
especially directed at his head.

I will have to look into Hydergine!

This lady has an aspirin allergy, I understand aspirin allergies can be overcome with small incremental increases but I wouldn't take the risk here. I seen the research , they will still prescribe statins and blood pressure lowering meds just in case of stroke they say ,even though aspirin will tick all the boxes and have potential to do more.

I was speaking to a Nurse the other day who claimed bloods were taken once a week with Alzheimer's patents a few years ago ,now it's stopped.
The family are enthusiastic about getting T3 ,rt3 checked,I'm going to through in transthyretin and a few others also.
I will report back,probably take a few weeks.

Your Dad seems to not react too much with supplements, have you tried T3 only?

The red light sounds good,this lady came back from respite care a few weeks ago with vitamin d3 supplment, the problem is I don't think they checked bloods for this,they seem to be just giving them out, I will find out for sure when next bloods are taken. She had an improvement in movement off the acetylcholine patch, since vitamin d3 was added she seems to be a little rigid again.

I think this allithiamine being fat soluble has potential, I'm going to try this when regular thiamine is finished.
 

narouz

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No, I haven't tried T3 on him yet--just the NDT, half a grain.
I think I'll have some thyroid labs done on him before I try that.
 
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