More On Cyproheptadine

haidut

Member
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
This is a continuation on my posts about cyproheptadine. Given that this is an independent "confirmation" of Peat's views I thought that it warranted. Some guy filed and was granted a patent on using serotonin antagonists, and especially cyproheptadine for the treatment of cancer, AIDS, Alzheimer's Disease (AD), and Multiple Sclerosis (MS). Read through the use cases reported, they are pretty interesting. What is also interesting is that the patent was filed in 1985 and granted in 1987, which is way before Peat created his website and even wrote about the effects of serotonin antagonists.
Here is the actual patent information:
http://www.google.com/patents/EP0214557A2

Even more interestingly, the same guy filed and was granted patents on using uric acid (a strong antioxidant with many benefits according to Peat) to treat AIDS, cancer and other viral diseases, and even aging itself.
https://www.google.com/patents/CA230486 ... CEAQ6AEwAQ

Finally, the same guy filed and was granted a patent on using serotonin antagonists for the treatment of anemia.
https://www.google.com/patents/US508112 ... CFwQ6AEwBQ

I don't think Peat has written on the connection between anemia and serotonin directly but I have seen other studies on PubMed claiming that there is a strong connection and using tryptophan depletion (which achieves similar results to serotonin antagonists) for treating anemia. So the next time somebody asks about safe anemia treatment without getting iron involved, we have one (potential) answer, which using cyproheptadine, ondansetron, or depleting tryptophan.
Thoughts?
 

nograde

Member
Joined
Oct 21, 2013
Messages
133

Blossom

Moderator
Joined
Nov 23, 2013
Messages
8,606
superhuman said:
dam cypro seems like a god pill.
Does anyone still use it now?
I do at least a few times per week.
 

sunmountain

Member
Joined
May 12, 2014
Messages
792
It helps me sleep. It probably is also one of the players in keeping stress hormones down, so that my body can tolerate increased thyroid. Until very recently, I could not increase thyroid since starting peating 3 months ago.
 
Joined
Jan 24, 2014
Messages
1,744
I use a half a pill (2 mg.) 2 or 3 nights per week. The results seem to last for days. I think if I took it every night it might be constipating, but that's just me.
 

jyb

Member
Joined
Nov 9, 2012
Messages
2,775
Location
UK
Cypro's effect on my libido are unique among all anti-serotonin methods I've tested.
 

narouz

Member
Joined
Jul 22, 2012
Messages
4,429
sunmountain said:
It helps me sleep. It probably is also one of the players in keeping stress hormones down, so that my body can tolerate increased thyroid. Until very recently, I could not increase thyroid since starting peating 3 months ago.

sun-
What were the bad effects when you tried to increase thyroid (before the cyproheptadine)?
 

sunmountain

Member
Joined
May 12, 2014
Messages
792
Narouz, my body's way of telling me to decrease thyroid is joint pains and intense fatigue. With daytime T3, it might also have been diarrhea. Nowadays I take cynoplus only, divided twice a day.

When I back off the increase, the joint pains and fatigue largely resolve.
 

Peat's sake

New Member
Joined
Oct 6, 2017
Messages
4
I have MS, recently diagnosed this year, that led me to find Ray Peat and change my low carb ways. I am now eating a peat inspired diet and have added both tyromix and tyronene to help my thyroid ( I was formerly on Nature throid but it didn't seem to work well for me) . I have been seriously considering taking cyproheptadine, and was thrilled to see this post. I have a weird sensation in my left eye, that I could most describe as feeling numb, when I first wake up. It goes away, and it doesn't affect my vision, but it hasn't gotten better since it appeared with my first MS attack, even though the other symptoms that first appeared, tingling and weakness in left arm and leg, have resolved for the most part. Are there any downsides or things that I might need to watch out for, if I attempt this antihistamine? I would love recommendations on dosing. My daughter is a nurse practicianer and going to write this for 8 mg per night, however, I am guessing I shouldn't start so high?
 

Ideonaut

Member
Joined
Sep 20, 2015
Messages
450
Location
Seattle
This is a continuation on my posts about cyproheptadine. Given that this is an independent "confirmation" of Peat's views I thought that it warranted. Some guy filed and was granted a patent on using serotonin antagonists, and especially cyproheptadine for the treatment of cancer, AIDS, Alzheimer's Disease (AD), and Multiple Sclerosis (MS). Read through the use cases reported, they are pretty interesting. What is also interesting is that the patent was filed in 1985 and granted in 1987, which is way before Peat created his website and even wrote about the effects of serotonin antagonists.
Here is the actual patent information:
Patent EP0214557A2 - Use of serotonin antagonists, particularly cyproheptadine, in the treatment of cancer, Alzheimer's disease, AIDS and multiple sclerosis

Even more interestingly, the same guy filed and was granted patents on using uric acid (a strong antioxidant with many benefits according to Peat) to treat AIDS, cancer and other viral diseases, and even aging itself.
https://www.google.com/patents/CA230486 ... CEAQ6AEwAQ

Finally, the same guy filed and was granted a patent on using serotonin antagonists for the treatment of anemia.
https://www.google.com/patents/US508112 ... CFwQ6AEwBQ

I don't think Peat has written on the connection between anemia and serotonin directly but I have seen other studies on PubMed claiming that there is a strong connection and using tryptophan depletion (which achieves similar results to serotonin antagonists) for treating anemia. So the next time somebody asks about safe anemia treatment without getting iron involved, we have one (potential) answer, which using cyproheptadine, ondansetron, or depleting tryptophan.
Thoughts?
What would be an effective method of depleting tryptophan beyond avoiding it in food?
 

Regina

Member
Joined
Aug 17, 2016
Messages
3,381
Location
Chicago
This is a continuation on my posts about cyproheptadine. Given that this is an independent "confirmation" of Peat's views I thought that it warranted. Some guy filed and was granted a patent on using serotonin antagonists, and especially cyproheptadine for the treatment of cancer, AIDS, Alzheimer's Disease (AD), and Multiple Sclerosis (MS). Read through the use cases reported, they are pretty interesting. What is also interesting is that the patent was filed in 1985 and granted in 1987, which is way before Peat created his website and even wrote about the effects of serotonin antagonists.
Here is the actual patent information:
Patent EP0214557A2 - Use of serotonin antagonists, particularly cyproheptadine, in the treatment of cancer, Alzheimer's disease, AIDS and multiple sclerosis

Even more interestingly, the same guy filed and was granted patents on using uric acid (a strong antioxidant with many benefits according to Peat) to treat AIDS, cancer and other viral diseases, and even aging itself.
https://www.google.com/patents/CA230486 ... CEAQ6AEwAQ

Finally, the same guy filed and was granted a patent on using serotonin antagonists for the treatment of anemia.
https://www.google.com/patents/US508112 ... CFwQ6AEwBQ

I don't think Peat has written on the connection between anemia and serotonin directly but I have seen other studies on PubMed claiming that there is a strong connection and using tryptophan depletion (which achieves similar results to serotonin antagonists) for treating anemia. So the next time somebody asks about safe anemia treatment without getting iron involved, we have one (potential) answer, which using cyproheptadine, ondansetron, or depleting tryptophan.
Thoughts?
:dancingsmileyman :clap: This approach (serotonin antagonists), along with increasing magnesium, seem to have healed my severe anemia.
 
Last edited:

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,608
Location
USA / Europe
What would be an effective method of depleting tryptophan beyond avoiding it in food?

Did you search the forum for "tryptophan depletion" or "serotonin depletion"? There must be at least 20 threads on those topics, not to mention numerous related comments by people trying their own methods.
 
Similar threads
Thread starter Title Forum Replies Date
A Cyproheptadine Increased My Cold Sensitivity Even More Ask For Help or Advice 4
OccamzRazer Raw milk for mood, bowel motility, and more! Testimonials 3
bzmazu More vitamin K2, more testosterone K 0
R Bullied youths are much more likely to have violent fantasies, new study shows Scientific Studies 1
Rinse & rePeat Brewer's Yeast A Cure For Diabetes And More.. Supplements, Pharmaceutical Drugs 5
U What is more beneficial for overall health: squats or sprinting? Exercise 2
Rinse & rePeat Kidney Consumption Lowers Histamines & More Organ Meat 29
Lokzo Mouth Taping Benefits Explored (Erections, Sleep Quality & More) Experiments 7
N Teeths pain when I do bike and try to go a little’ more intense Ask For Help or Advice 0
IVILA How to sweat more Ask For Help or Advice 10
Hans Problems with the carnivore diet (Pros, cons, side effects, glucose deficiency and more) Discussing Dietary Models 13
ecstatichamster Vaccines cause more dangerous strains to evolve and shed (from vaccinated hosts) Vaccines 9
Blaze There are more drug related deaths from aspirin than any other drug on the planet. Ask For Help or Advice 38
OccamzRazer More vascularity in one arm than in the other? Miscellaneous 16
D Is Willow Bark More Effective Than Aspirin > For Pain/Inflamation? Aspirin 0
R Optimal amount of cardiovascular exercise per day? 30 minutes? 60 minutes? More? Ask For Help or Advice 6
A Anti-aging, more collagen production, youthful appearance due to glitch re: histamine? Miscellaneous Health Discussions 5
BearWithMe Everything that should improve thyroid makes me more hypothyroid Ask For Help or Advice 116
A How to become more physically attractive to girls/women? Ask For Help or Advice 198
David PS Ray Peat Interview Jodellfit - Dr Ray Peat - Hormone Replacement, Thyroid, Frequent Snacking, Chronic Fatigue and more Q&A Interviews 4
P Made one change to coffee, now no more stress Coffee 23
emac More Saturated fat seems to have cured my adhd + reduced my facial bloating. Diet 36
Mauritio GABA decreases flouride inuced hypothyroidism; more effective than thyroid hormone Thyroid and Hormones 24
B Mouth Taping at Night = More Nocturia Insomnia, Sleep Issues 7
GreekDemiGod Wealth / money will improve your metabolism more than anything Miscellaneous 42
Mauritio Cistanche more effective at decreasing lipid peroxidation and free radicals than Vitamin E and Caffeine Science 46
bzmazu Big Tech Pushes Digital ID Cards to Track Vaccinations, Shopping, Banking Activity and More Political Talk, Alternative World Theories 20
ScurveDream Leanness and physiology -- how does it all work (more of a rant)? Metabolism 1
biggirlkisss What are good books to learn biology etc to understand the science more deeply? Ask For Help or Advice 3
N Why testosterone, dht makes me more fatigue? Mental Issues 4
C Why do indigenous people have bigger and more defined jaws? Diet 21
GorillaHead Which one increases core body temp more? Glucose or fructose and or combination? Diet 23
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 17
Mauritio Caprylic acid effective against Candida albicans , H. Pylori and Cytomegalovirus, more effective than diflucan Science 14
M Organic Milk Contains More PUFA? Diet 3
Herbie Saturated fat protects alcoholics, so why not drink more? Alcohol, Tobacco, Drugs 14
bzmazu More good news on Ivermectin.... Viruses, Parasites, Fungus, Vaccines 0
J Smaller, more frequent meals = night time hunger Diet 4
E Is Vitex a.k.a. chasteberry more positive than negative and your thoughts on whether it is bad for the testicles? Supplements 3
TypicalJock Could milk possibly give me more acne? Ask For Help or Advice 8
haidut More Japanese Suicides In October, Than COVID-19 Deaths In Entire 2020 Scientific Studies 8
Max. Astaxanthin Is More Potent Than Saw Palmeto In Reducing 5AR? Ask For Help or Advice 9
Lokzo It’s MORe Exciting Than Mu: Crosstalk Between Mu Opioid Receptors And Glutamatergic Transmission Scientific Studies 0
Harryedgar Pufa Seems More Anabolic Than SAT Here - What Do Y’all Think? Polyunsaturated Fats, Seed Oils 4
ecstatichamster Study Shows Lockdowns Cause More Infection Than Not Scientific Studies 3
T I Missed My 5 Mg Evening Dose Of Valium, Now Have More Physical Anxiety Is This Neurological Damage? Ask For Help or Advice 33
GorillaHead Metals And Androgenic Alopecia. More To It? Hair & Nails 3
J Eating Liver Makes Me Feel Cold More Often And Faster, Why? Metabolism 7
RealNeat Mexico Is Looking More And More Attractive. Any Advice Or Suggestions? Diet 24
not_James_Bond Man Gets Covid Twice And Second Hit 'more Severe' Viruses, Parasites, Fungus, Vaccines 7

Similar threads

Top