- Mar 20, 2021
Does anyone have any experience utilizing Niclosamide for fat loss via mitochondrial uncoupling? It is purported to have a similar action to DNP without the risks.... Thanks!
Thank you! Yes, I've seen this study too. I am so curious to see how it works for non-mice ... @Hans mentioned it as a safer alternative to DNP...
Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice
Hanlin Tao 1 , Yong Zhang 1 , Xiangang Zeng 2 , Gerald I Shulman 3 , Shengkan Jin 1
Type 2 diabetes (T2D) has reached an epidemic level globally. Most current treatments ameliorate the hyperglycemic symptom of the disease but are not effective in correcting its underlying cause. One important causal factor of T2D is ectopic accumulation of lipids in metabolically sensitive organs such as liver and muscle. Mitochondrial uncoupling, which reduces cellular energy efficiency and increases lipid oxidation, is an appealing therapeutic strategy. The challenge, however, is to discover safe mitochondrial uncouplers for practical use. Niclosamide is an anthelmintic drug approved by the US Food and Drug Administration that uncouples the mitochondria of parasitic worms. Here we show that niclosamide ethanolamine salt (NEN) uncouples mammalian mitochondria at upper nanomolar concentrations. Oral NEN increases energy expenditure and lipid metabolism in mice. It is also efficacious in preventing and treating hepatic steatosis and insulin resistance induced by a high-fat diet. Moreover, it improves glycemic control and delays disease progression in db/db mice. Given the well-documented safety profile of NEN, our study provides a potentially new and practical pharmacological approach for treating T2D.
Apparently the benefits exceed the effects on the mitochondria. As with ivermectin, it has demonstrated antiviral activity, anti-cancer benefit, and anti-alzheimer potential.
I've seen it recommended along with Ivermectin...
Well I ordered some Niclosamide. 120 capsules, 500mg each.. I will report backYes that one too. The niclosamide/bromhexine combo inhibits both paths of viral entry into a cell (TMPRSS2 and something else I can't remember). I read about it from this guy who did a lot of research into treatments.
Can you tell from where you obtained the Niclosamide?
What would your dosage be and for how long?Yeah, Perry's link above. That's where I ordered from... Hasn't shown up yet...
The capsules have 500mg each. I'm going to start out by taking one with my breakfast and see how that feels for a whileWhat would your dosage be and for how long?
I came across a study I believe used 5mg/kg in rats or mice. But higher doses were also used if I remember correctly.
I am interested in this as well.
I get my info from studies. :)
Thanks for your time!!❤ - loving your podcasts, too. I'm always tuning in within hours of uploads....I get my info from studies. :)
I haven't tried it myself, and don't think it's as well-known or common as DNP. I also think that any "short cut" for fat loss comes with some form of risk profile.
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