Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Very interesting study on Sodium Butyrate and weight loss/inflammation.
The researchers fed mice a high fat diet(HFD) and gave some of them Sodium butyrate (I think it was 5% of the diet) as a supplement.
Not only did the butyrate +HFD-mice weigh less (~20%) than the HFD-mice, they weighed even less than the control group, receiving a normal diet!
Plus they ate about 10% more food than the control animals.
Eating more food and gaining less weight. Sounds familiar ? ...maybe there's some uncoupling going on.
This is corroborated by the fact that the butyrate +HFD-mice had the same amount of total fat than the controls, but less white fat. So the rest was probably brown (or beige) fat, which is known for higher levels of heat production/uncoupling than white fat.
So sodium butyrate might have induced a higher state of uncoupling in those animals.
The full text shows UCP1 was almost non-existent HFD mice ,while it was restored to control levels in the butyrate-mice.
They also showed no reduction of lean mass, which is typical for uncoupling and the reason why DNP is so popular amognst body builders.
The butyrate-fed mice also showed better glucose tolerance and lower overall inflammation, which might just be a result of lower systemic endotoxin levels, through butyrate's abilty to decrease intestinal permeability,
As the authors explain:
"Earlier reports have shown gut leakage and increased LPS in circulation is the primary cause of setting up inflammation at the tissue level."
www.ncbi.nlm.nih.gov
The researchers fed mice a high fat diet(HFD) and gave some of them Sodium butyrate (I think it was 5% of the diet) as a supplement.
Not only did the butyrate +HFD-mice weigh less (~20%) than the HFD-mice, they weighed even less than the control group, receiving a normal diet!
Plus they ate about 10% more food than the control animals.
Eating more food and gaining less weight. Sounds familiar ? ...maybe there's some uncoupling going on.
This is corroborated by the fact that the butyrate +HFD-mice had the same amount of total fat than the controls, but less white fat. So the rest was probably brown (or beige) fat, which is known for higher levels of heat production/uncoupling than white fat.
So sodium butyrate might have induced a higher state of uncoupling in those animals.
The full text shows UCP1 was almost non-existent HFD mice ,while it was restored to control levels in the butyrate-mice.
They also showed no reduction of lean mass, which is typical for uncoupling and the reason why DNP is so popular amognst body builders.
The butyrate-fed mice also showed better glucose tolerance and lower overall inflammation, which might just be a result of lower systemic endotoxin levels, through butyrate's abilty to decrease intestinal permeability,
As the authors explain:
"Earlier reports have shown gut leakage and increased LPS in circulation is the primary cause of setting up inflammation at the tissue level."
Sodium butyrate reduces endoplasmic reticulum stress by modulating CHOP and empowers favorable anti-inflammatory adipose tissue immune-metabolism in HFD fed mice model of obesity
Over the past decade, the gut microbiome has been linked to several diseases including gastrointestinal diseases, cancer, immune disorder and metabolic syndrome. Shifts in the gut bacterial population affect the overall metabolic health status leading ...
www.ncbi.nlm.nih.gov
