Uncoupling Increases Life Span And Generates More Mitochondria

[Mauritio]

Dont know if this study has been posted before ,one way or another it is worth a read!


Uncoupling protein-2 and the potential link between metabolism and longevity.
The discovery of novel uncoupling proteins (UCP2 and UCP3) over 10 years ago heralded a new era of research in mitochondrial uncoupling in a diverse range of tissues. Despite the research vigor, debate stills surrounds the exact function of these uncoupling proteins. For example, the level of uncoupling, the mechanism and mode of action are all under-appreciated at this point in time. Our recent work has used genetic mouse models to focus on the physiological relevance of UCP2. We have used these mouse models to better appreciate the role UCP2 in human health and disease. In this review we focus on new research showing that UCP2 promotes longevity by shifting a given cell towards fatty acid fuel utilization. This metabolic hypothesis underlying UCP2-dependent longevity suggests that UCP2 is critically positioned to maintain fatty acid oxidation and restrict subsequent oxidative damage allowing sustained mitochondrial oxidative capacity and mitochondrial biogenesis. These mechanisms converge within the cell to boost cell function and metabolism and the net result promotes healthy aging and increased lifespan. Finally, UCP2 is a useful dietary and therapeutic target to promote lifespan and is an important mitochondrial protein connecting longevity to metabolism.


Uncoupling protein-2 and the potential link between metabolism and longevity. - PubMed - NCBI

 

[ecstatichamster]

Nothing wrong with this. It’s a publication. But it is not a study. Just saying.

 

[Inaut]

@Hans has posted some good info about uncoupling mitochondria and provided some great suggestions to assist

 

[Mauritio]

@Hans has posted some good info about uncoupling mitochondria and provided some great suggestions to assist

Would You mind showing me where he said that?

 

[Hans]

Here's my article on it Uncoupling: Secret to Fat loss and Health

And here is the thread where we discusses body temps and stuff: [Discussion] Raising Body Temperature

 

[Mauritio]

Here's my article on it Uncoupling: Secret to Fat loss and Health

And here is the thread where we discusses body temps and stuff: [Discussion] Raising Body Temperature

Thanks! very interesting.