Mauritio
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- Joined
- Feb 26, 2018
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In this study they gave middle aged people "2 MIB-626 tablets each containing 500 mg of microcrystalline β-nicotinamide mononucleotide or placebo twice daily for 28 days."
Most notably the participants lost about 1.9kg of body weight in just 28 days.
Now was all over that fat ? Hard to say.
At least it seems like it wasnt muscle since they didnt show any decrease in strength.
On the other hand liver and intra-abdominal fat didn't change, so it might be subcutaneous fat or water weight (or a mix of those) that they lost.
The fact that the lowered weight correlates with a decrease in cholesterol might mean that there was an increase in thyroid function.
Either way, almost 2kg in one month is a pretty decent amount of weight loss. If they could keep that up for a year that'd be about 24kg of weight loss! Pretty significant. So I'd like to see a long term study using a similar approach.
"Body weight (difference -1.9 [-3.3, -0.5] kg, P = .008); diastolic blood pressure (difference -7.01 [-13.44, -0.59] mmHg, P = .034); total cholesterol (difference -26.89 [-44.34, -9.44] mg/dL, P = .004), low-density lipoprotein (LDL) cholesterol (-18.73 [-31.85, -5.60] mg/dL, P = .007), and nonhigh-density lipoprotein cholesterol decreased significantly more in the MIB-626 group than placebo. Changes in muscle strength, muscle fatigability, aerobic capacity, and stair-climbing power did not differ significantly between groups. Insulin sensitivity and hepatic and intra-abdominal fat did not change in either group."
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study - PubMed
Most notably the participants lost about 1.9kg of body weight in just 28 days.
Now was all over that fat ? Hard to say.
At least it seems like it wasnt muscle since they didnt show any decrease in strength.
On the other hand liver and intra-abdominal fat didn't change, so it might be subcutaneous fat or water weight (or a mix of those) that they lost.
The fact that the lowered weight correlates with a decrease in cholesterol might mean that there was an increase in thyroid function.
Either way, almost 2kg in one month is a pretty decent amount of weight loss. If they could keep that up for a year that'd be about 24kg of weight loss! Pretty significant. So I'd like to see a long term study using a similar approach.
"Body weight (difference -1.9 [-3.3, -0.5] kg, P = .008); diastolic blood pressure (difference -7.01 [-13.44, -0.59] mmHg, P = .034); total cholesterol (difference -26.89 [-44.34, -9.44] mg/dL, P = .004), low-density lipoprotein (LDL) cholesterol (-18.73 [-31.85, -5.60] mg/dL, P = .007), and nonhigh-density lipoprotein cholesterol decreased significantly more in the MIB-626 group than placebo. Changes in muscle strength, muscle fatigability, aerobic capacity, and stair-climbing power did not differ significantly between groups. Insulin sensitivity and hepatic and intra-abdominal fat did not change in either group."
- Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study - PubMed