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nad/nadh
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Niacinamide may treat Parkinson Disease (PD)
A very interesting study, which used a relatively high dose of nicotinamide riboside (NR) to treat Parkinson Disease (PD). The dosage used was 3,000mg daily for 4 weeks and it resulted in improvement of motor and cognitive symptoms of PD, while producing no side effects. The study references...- haidut
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- nad nad/nadh niacinamide nicotinamide riboside oxphos parkinson vitamin b3
- Replies: 9
- Forum: Scientific Studies
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Increasing NAD lowers body weight, cholesterol and blood pressure
In this study they gave middle aged people "2 MIB-626 tablets each containing 500 mg of microcrystalline β-nicotinamide mononucleotide or placebo twice daily for 28 days." Most notably the participants lost about 1.9kg of body weight in just 28 days. Now was all over that fat ? Hard to say...- Mauritio
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- blood pressure cholesterol nad nad+ nad/nadh nicotinamide mononucleotide weight loss
- Replies: 38
- Forum: Scientific Studies
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Microdosing nicotine increases NAD levels and rejuvenates old mice
This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...- Mauritio
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- nad nad+ nad/nadh nampt nicotine
- Replies: 58
- Forum: Scientific Studies
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Fatty acid oxidation - linking all illness (especially cancer) with stress and diet (fasting / low-carb)
The study below is one perhaps the most comprehensive review published to date, challenging the medical dogma that cancer is a genetic/mutation disease. As the study aptly explains, the evidence, spanning as far back as Otto Warburg's original work on this disease, is overwhelmingly in support...- haidut
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- cancer fasting fatty acid oxidation low-carb nad/nadh randle cycle redox
- Replies: 26
- Forum: Scientific Studies
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Cancer relies on fat as fuel due to high reductive stress
One of the few studies out there that not only links cancer with impaired OXPHOS, but demonstrates directly the role of reductive stress (exemplified by the NAD/NADH ratio) in cancer's appetite for fats as fuel required for the cancer survival and proliferation/metastasis. It also once again...- haidut
- Thread
- cancer fat fatty acid oxidation nad nad/nadh oxphos oxygen redox
- Replies: 11
- Forum: Scientific Studies
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Endotoxin (LPS) drives CD38 expression and therefore seems to effect NAD levels
How To Inhibit CD38 As We Age | LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5- Ismail
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- cd38 endotoxin lps nad+ nad/nadh nicotinamide mononucleotide nicotinamide riboside nmn
- Replies: 0
- Forum: Carrot Salad, Bamboo Shoots, Mushrooms
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An optimal metabolism: a look at the furnace within
What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...- Hans
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- lactate nad+ nad/nadh pyruvate redox redox homeostasis
- Replies: 15
- Forum: Articles & Scientific Studies
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Alcohol Causes Liver (and Other Organ) Damage By Lowering NAD/NADH Ratio
A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the...- haidut
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- alcohol damage liver nad nad/nadh nadh organ redox
- Replies: 6
- Forum: Scientific Studies
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Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females
A great new study, which once again confirms the importance of metabolism in "aging" disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide...- haidut
- Thread
- infertility low dose menopause nad nad/nadh niacinamide reverse vitamin b3
- Replies: 9
- Forum: Scientific Studies
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Pyrucet - Liquid (ethyl) Pyruvate/Aceatoacetate Mix
As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on... -
Giving Niacinamide To Pregnant Females Greatly Benefits The Offspring
A few very interesting studies came out in 2018 showing that niacinamide may be very helpful for (pre)-eclampsia, as well as prevent miscarriages and birth defects. Keep in mind that according to mainstream medicine, eclampsia is untreatable and the approach is to have the baby delivered ASAP...- haidut
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- bdnf beneficial intelligence nad nad+ nad/nadh niacinamide nicotinamide riboside offspring pregnant
- Replies: 2
- Forum: Scientific Studies
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Niacinamide Can Treat Alcoholic Liver Disease
As many forum users have probably heard on the news, alcohol abuse is now a leading cause of death in young people under 35. It is projected to soon surpass drug overdose as a cause of death in this demographic. Millennials are dying of alcohol-related liver disease at increasing rates The...- haidut
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- alcohol alcoholism cirrhosis liver liver disease liver steatosis nad nad/nadh niacinamide nicotinamide riboside nr prevent redox
- Replies: 3
- Forum: Scientific Studies
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Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study
It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...- haidut
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- acute kidney injury aki creatinine kidney disease kidney failure nad nad+ nad/nadh niacinamide redox status
- Replies: 6
- Forum: Scientific Studies
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Niacinamide May Be A Viable Treatment For Parkinson Disease (PD)
It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to...- haidut
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- disease energy mitochondria nad nad/nadh nam niacinamide nicotinamide riboside nr parkinson
- Replies: 8
- Forum: Scientific Studies
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Estrogen As The Main Cause Of Cancer And Its Progression
I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...- haidut
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- cancer estrogen estrogen receptor fatty acid oxidation glycolysis hif hif-1 hypoxia lactate lactic acid mitochondria nad/nadh pdh pdk pyruvate randle cycle redox homeostasis warburg cause warburg cycle warburg effect
- Replies: 18
- Forum: Scientific Studies
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Inosine Increases NAD/NADH Ratio And Reduces Systemic Inflammation
Yet another great study on inosine. It shows that a HED of just 8mg/kg administered just twice daily increased the NAD/NADH ratio by a whopping factor of 15 (see attached screenshot). While inosine itself is neither a precursor to NAD (like niacinamide) nor is it an oxidizing agent, I think its...- haidut
- Thread
- inflammation inosine nad nad/nadh nadh raio redox homeostasis sepsis
- Replies: 69
- Forum: Scientific Studies
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NAD/NADH Ratio - The One Metabolic Cause To Rule Them All
Yes, there is a congestion and it is called excessive glycolysis and not enough Krebs cycle activity or electron transport chain (ETC) activity. I mentioned this a few times in the Danny Roddy podcasts. Carbs go through glycolysis and generate pyruvate. In the process existing NAD in the body is...