nad/nadh

What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...

A neat little study, which demonstrates once again the crucial role of energy and optimal redox status in a public health issue that has now reached catastrophic proportions. Namely, alcohol-related morbidity and mortality. Those have always been an issue in any developed country but since the...

A great new study, which once again confirms the importance of metabolism in "aging" disorders such as infertility (both female and male) and menopause. More specifically, it was the increase in NAD/NADH ratio that was the main mechanism of action behind the beneficial effects of nicotinamide...

As many forum users know, I have been interested in the Randle Cycle (glucose/fat competition for oxidation) for quite some time. The topic of limiting fatty acid oxidation (FAO) and promoting glucose oxidation is pretty central to the metabolic theory of health. Peat has written many times on...

A few very interesting studies came out in 2018 showing that niacinamide may be very helpful for (pre)-eclampsia, as well as prevent miscarriages and birth defects. Keep in mind that according to mainstream medicine, eclampsia is untreatable and the approach is to have the baby delivered ASAP...

As many forum users have probably heard on the news, alcohol abuse is now a leading cause of death in young people under 35. It is projected to soon surpass drug overdose as a cause of death in this demographic. Millennials are dying of alcohol-related liver disease at increasing rates The...

It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...

It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to...

I think many of the forum users here know about the infamous study that generated a lot of controversy on "scientific" forums like Reddit. It basically showed that the Warburg Effect (overproduction of lactate) is not just an effect but a direct cause of cancer. So, as the top rated comment on...

Yet another great study on inosine. It shows that a HED of just 8mg/kg administered just twice daily increased the NAD/NADH ratio by a whopping factor of 15 (see attached screenshot). While inosine itself is neither a precursor to NAD (like niacinamide) nor is it an oxidizing agent, I think its...