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  1. Drareg

    US Military Anti Aging Pill

    So what is this amazing pill that your tax dollars will be paying for? Its nad+ repackaged into a small molecule formula. Team America could use this to help society in general by giving it to the entire nation for free but in true team America style we must first use it to enhance the killing...
  2. Ismail

    Endotoxin (LPS) drives CD38 expression and therefore seems to effect NAD levels

    How To Inhibit CD38 As We Age | LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5
  3. Hans

    An optimal metabolism: a look at the furnace within

    What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...
  4. haidut

    Giving Niacinamide To Pregnant Females Greatly Benefits The Offspring

    A few very interesting studies came out in 2018 showing that niacinamide may be very helpful for (pre)-eclampsia, as well as prevent miscarriages and birth defects. Keep in mind that according to mainstream medicine, eclampsia is untreatable and the approach is to have the baby delivered ASAP...
  5. haidut

    Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study

    It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...
  6. P

    Nothing Boring About Boron

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/ The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As...
  7. haidut

    Niacinamide Retards/Reverses Aging And Physiological Decline

    Yet another study on the beneficial effects of raising NAD levels, and unlike other recent studies this one is not sponsored by ChromaDex. This study used nicotinamide mononucleotide (NMN), and human studies have shown that niacinamide is equally effective as NMN in raising NAD levels. Also, as...
  8. haidut

    NAD/NADH Ratio - The One Metabolic Cause To Rule Them All

    Yes, there is a congestion and it is called excessive glycolysis and not enough Krebs cycle activity or electron transport chain (ETC) activity. I mentioned this a few times in the Danny Roddy podcasts. Carbs go through glycolysis and generate pyruvate. In the process existing NAD in the body is...
  9. P

    Vitamin B3 Modulates Mitochondrial Vulnerability And Prevents Glaucoma In Aged Mice

    Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. - PubMed - NCBI Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are...
  10. haidut

    Niacinamide Reverses / Cures Duchenne Muscular Dystrophy

    It is well known even in mainstream medical circles that autoimmune conditions are characterized by greatly reduced levels of NAD. I posted a few studies in the past showing that raising NAD levels through supplementation of niacinamide can help virtually any autoimmune condition. This study...
  11. P

    Taurine Increases NAD+

    Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. - PubMed - NCBI Abstract PURPOSE: To evaluate changes in glutathione and NAD(P)-redox status, taurine and malondialdehyde (MDA) levels, glucose...
  12. P

    Methylene Blue Protection Against Hypoxic Injury In Primary Cultures Of Rat Hepatocyte Monolayers

    Methylene blue protection against hypoxic injury in primary cultures of rat hepatocyte monolayers. - PubMed - NCBI Mitochondrial respiration is inhibited in cells exposed to hypoxia, and the oxidation of NADH to NAD(+) is blocked. As a result, oxidation reactions requiring NAD(+) are blocked...
  13. P

    NAD⁺ Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice

    NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - PubMed - NCBI Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized...
  14. haidut

    Recovering Steroidogenesis Inhibited By Alcohol And Drugs

    As many of you know, drugs like Finasteride are really bad not only because they cause a variety of CNS effects as a result of inhibiting 5-AR, but also because they systemically inhibit the entire steroid synthesis cascade. Toxins and alcohol do the same and currently there is no approved...
  15. cantstoppeating

    Generative Energy #26: Talking With Ray Peat #2: Carbon Dioxide, NAD+/NADH, Antibiotics, Coffee

    (or watch directly on youtube where the description has clickable links to different topics) Play the audio from a web page: #26: Talking with Ray Peat #2: Carbon Dioxide, NAD+/NADH, Antibiotics, Coffee Subscribe in a podcasts app: Use iTunes: Generative Energy Podcast by Danny Roddy on iTunes...
  16. LukeL

    Can Someone Explain NAD+/NADH Ratio To Me In A Digestible Way?

    Much appreciated!
  17. P

    Medium-chain Triglyceride Supplementation Under A Low-carbohydrate Formula Is A Promising Therapy

    Medium-chain triglyceride supplementation under a low-carbohydrate formula is a promising therapy for adult-onset type II citrullinemia Results One of the patients displaying hyperammonemic encephalopathy completely recovered with all normal laboratory findings. Others notably improved in...
  18. haidut

    Niacinamide Fully Prevents Breast Cancer Metastasis

    In yet another winning day (as Trump likes to say) for niacinamide, this study shows that the metastatic process of breast cancer is controlled by the NAD/NADH ratio, and NAD precursors like niacinamide can be effective chemotherapeutic agents. The human equivalent dose was 3g - 3.5g daily for a...
  19. P

    Caffeine: Neuroprotective Against Quinolinic Acid Induced Mitochondrial Dysfunction; Huntington's

    http://www.ncbi.nlm.nih.gov/pubmed/25443748 Abstract BACKGROUND: Chronic quinolinic acid (QA) lesions in rats closely resemble Huntington's disease like conditions. Oxidative stress and mitochondrial dysfunction have long been implicated in the neurotoxic effects of QA acting through...
  20. haidut

    Raising Levels Of Nad+ Reverses Damage Of Diseases Like Ms

    The study author says that this should apply to virtually all auto-immune conditions (including allergies), not just MS. Raising levels of NAD+ in the body both reduced the severity of new disease onset, and also reversed the damage caused by already established disease...