nad+

  1. Mauritio

    Increasing NAD lowers body weight, cholesterol and blood pressure

    In this study they gave middle aged people "2 MIB-626 tablets each containing 500 mg of microcrystalline β-nicotinamide mononucleotide or placebo twice daily for 28 days." Most notably the participants lost about 1.9kg of body weight in just 28 days. Now was all over that fat ? Hard to say...
    • Mauritio
    • Thread
    • blood pressure cholesterol nad nad+ nad/nadh nicotinamide mononucleotide weight loss
    • Replies: 38
    • Forum: Scientific Studies
  2. Mauritio

    Microdosing nicotine increases NAD levels and rejuvenates old mice

    This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...
  3. A

    Pyruvate Potentially Superior to NAD+ and Senolytics in Healthy Aging

    https://pubmed.ncbi.nlm.nih.gov/34720589/ Abstract This review aimed at evoking attention of sodium pyruvate effects on healthy aging relative to the nicotinamide adenine dinucleotide oxidized form (NAD+) and senolytics. In last decades, healthy aging has become one of research hotspots in life...
  4. A

    Diflunisal, a salicylic acid derivative, has the potential to increase NAD+ levels

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856275/ Abstract In the kynurenine pathway for tryptophan degradation, an unstable metabolic intermediate, α-amino-β-carboxymuconate-ε-semialdehyde (ACMS), can nonenzymatically cyclize to form quinolinic acid, the precursor for de novo biosynthesis...
  5. A

    A systems-approach to NAD+ restoration

    https://www.sciencedirect.com/science/article/pii/S0006295222000405 Alternative strategies to boost NAD+ Given these drawbacks of simple precursor supplementation, strategies that address the root causes of NAD+ decline by considering multiple key nodes of the NAD+ interactome seem more...
  6. Drareg

    US Military Anti Aging Pill

    So what is this amazing pill that your tax dollars will be paying for? Its nad+ repackaged into a small molecule formula. Team America could use this to help society in general by giving it to the entire nation for free but in true team America style we must first use it to enhance the killing...
    • Drareg
    • Thread
    • nad+ niacinamide
    • Replies: 3
    • Forum: Society
  7. Ismail

    Endotoxin (LPS) drives CD38 expression and therefore seems to effect NAD levels

    How To Inhibit CD38 As We Age | LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5
  8. Hans

    An optimal metabolism: a look at the furnace within

    What should a true metabolism look like? What should we even look at? I dived a bit deep on this one and hopefully it provides answers for some. I'm discussing redox couples, such as NAD/NADH, GSH/GSSG and cysteine/cystine and how they affect energy production, ROS, hormone and neurotransmitter...
  9. haidut

    Giving Niacinamide To Pregnant Females Greatly Benefits The Offspring

    A few very interesting studies came out in 2018 showing that niacinamide may be very helpful for (pre)-eclampsia, as well as prevent miscarriages and birth defects. Keep in mind that according to mainstream medicine, eclampsia is untreatable and the approach is to have the baby delivered ASAP...
    • haidut
    • Thread
    • bdnf beneficial intelligence metabolic rate metabolism nad nad+ nad/nadh niacinamide nicotinamide riboside offspring pregnant
    • Replies: 2
    • Forum: Scientific Studies
  10. haidut

    Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study

    It seems modern medicine is slowly starting to recognize the role of energy in organ health, and more specifically the role of NAD/NADH ratio in variety of diseases long thought to be mostly mechanism in origin. A few months ago, I posted a study on raising NAD levels with nicotinamide riboside...
    • haidut
    • Thread
    • acute kidney injury aki creatinine kidney disease kidney failure nad nad+ nad/nadh niacinamide redox status
    • Replies: 6
    • Forum: Scientific Studies
  11. P

    Nothing Boring About Boron

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/ The trace mineral boron is a micronutrient with diverse and vitally important roles in metabolism that render it necessary for plant, animal, and human health, and as recent research suggests, possibly for the evolution of life on Earth. As...
  12. haidut

    Niacinamide Retards/Reverses Aging And Physiological Decline

    Yet another study on the beneficial effects of raising NAD levels, and unlike other recent studies this one is not sponsored by ChromaDex. This study used nicotinamide mononucleotide (NMN), and human studies have shown that niacinamide is equally effective as NMN in raising NAD levels. Also, as...
    • haidut
    • Thread
    • aging nad nad+ niacinamide nicotinamide mononucleotide nmn reversal vitamin b3
    • Replies: 32
    • Forum: Scientific Studies
  13. haidut

    NAD/NADH Ratio - The One Metabolic Cause To Rule Them All

    Yes, there is a congestion and it is called excessive glycolysis and not enough Krebs cycle activity or electron transport chain (ETC) activity. I mentioned this a few times in the Danny Roddy podcasts. Carbs go through glycolysis and generate pyruvate. In the process existing NAD in the body is...
    • haidut
    • Thread
    • nad nad+ nad/nadh
    • Replies: 224
    • Forum: Science
  14. P

    Vitamin B3 Modulates Mitochondrial Vulnerability And Prevents Glaucoma In Aged Mice

    Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. - PubMed - NCBI Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are...
  15. haidut

    Niacinamide Reverses / Cures Duchenne Muscular Dystrophy

    It is well known even in mainstream medical circles that autoimmune conditions are characterized by greatly reduced levels of NAD. I posted a few studies in the past showing that raising NAD levels through supplementation of niacinamide can help virtually any autoimmune condition. This study...
    • haidut
    • Thread
    • duchenne dystrophy myopathy nad nad+ niacinamide study treatment
    • Replies: 13
    • Forum: Scientific Studies
  16. P

    Taurine Increases NAD+

    Effect of dietary taurine supplementation on GSH and NAD(P)-redox status, lipid peroxidation, and energy metabolism in diabetic precataractous lens. - PubMed - NCBI Abstract PURPOSE: To evaluate changes in glutathione and NAD(P)-redox status, taurine and malondialdehyde (MDA) levels, glucose...
  17. P

    Methylene Blue Protection Against Hypoxic Injury In Primary Cultures Of Rat Hepatocyte Monolayers

    Methylene blue protection against hypoxic injury in primary cultures of rat hepatocyte monolayers. - PubMed - NCBI Mitochondrial respiration is inhibited in cells exposed to hypoxia, and the oxidation of NADH to NAD(+) is blocked. As a result, oxidation reactions requiring NAD(+) are blocked...
  18. P

    NAD⁺ Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice

    NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - PubMed - NCBI Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized...
  19. haidut

    Recovering Steroidogenesis Inhibited By Alcohol And Drugs

    As many of you know, drugs like Finasteride are really bad not only because they cause a variety of CNS effects as a result of inhibiting 5-AR, but also because they systemically inhibit the entire steroid synthesis cascade. Toxins and alcohol do the same and currently there is no approved...
  20. cantstoppeating

    Generative Energy #26: Talking With Ray Peat #2: Carbon Dioxide, NAD+/NADH, Antibiotics, Coffee

    (or watch directly on youtube where the description has clickable links to different topics) Play the audio from a web page: #26: Talking with Ray Peat #2: Carbon Dioxide, NAD+/NADH, Antibiotics, Coffee Subscribe in a podcasts app: Use iTunes: Generative Energy Podcast by Danny Roddy on iTunes...
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