Increasing NAD lowers body weight, cholesterol and blood pressure

[Mauritio]

You know, I experience this too. I eat with so much pleasure after niacinamide 250mg. Perhaps the net effect is a zero, but there is clearly something happening there. Good thought.

I have that same response to glycine and aspirin . Food legitimately tates better. And sometines I even loose weight when binging. Sometines I gain weight.

 

[Frankdee20]

Perhaps that's why I crave meat when I take niacinamide? Wouldn't lots of orange juice and meat be enough to support the methyl pool?

You know, I experience this too. I eat with so much pleasure after niacinamide 250mg. Perhaps the net effect is a zero, but there is clearly something happening there. Good thought.

It’s the way people on this forum go extreme, and the majority support them here, that this can get misconstrued with the status quo here, but status quo is not always objective…

 

[Mauritio]

Here's an interesting new study on NAD/NAM .

Can anybody get the full text??

Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet - PubMed

Obesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD⁺ ) is an important molecule in energy and signal transduction, and NAD⁺ supplementation therapy is a new...

pubmed.ncbi.nlm.nih.gov

 

[Motorneuron]

Here's an interesting new study on NAD/NAM .

Can anybody get the full text??

Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet - PubMed

Obesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD⁺ ) is an important molecule in energy and signal transduction, and NAD⁺ supplementation therapy is a new...

pubmed.ncbi.nlm.nih.gov

It makes me wonder if inhibition of SIRT6 (like curcumin) is positive.

Furthermore, it has never been clarified whether low-dose niacinamide (for example below 500mg?) is an activator of SIRT, while doses above 500mg? is inhibitory towards SIRT (which subset and in which organ I don't know).

Perhaps it has already been said, but if we combine ribose with niacinamide we would probably have NMR at a lower cost.

I had written the reports somewhere, hope to find and post them...maybe there was a thread about "fusion vs fission" mitochondria on Longecity.

 

[David PS]

It makes me wonder if inhibition of SIRT6 (like curcumin) is positive.

I do not think it is good to inhibit SIRT6. This is especially important as people age. See the graphs at:

Natural polyphenols as sirtuin 6 modulators

Natural polyphenols as sirtuin 6 modulators (2018) Flavonoids are polyphenolic secondary metabolites synthesized by plants and fungus with various pharmacological effects. Due to their plethora of biological activities, they have been studied extensively in drug development. They have been...

raypeatforum.com

 

[Motorneuron]

@David PS I forgot this thread thanks I'll go see it

 

[Motorneuron]

@David PS Maybe I was wrong, it seems turmeric/curcumin would activate SIRT6. Let me know based on your searches if you find anything Thanks

 

[David PS]

@Backtolife90 - Okay

 

[Mauritio]

The whole sirtuin thing seems kind of confusing to me.
I think someone should do an comprehensive "Sirtuins through a Peat-prism" thread.

How come peat said increasing NAD+ is good but sirtuins are bad ,when nad is a coenzyme for
sirtuins and thus will increase its production.

"Upregulation of NAMPT activates sirtuins primarily through the increase in NAD+ biosynthesis ..."
- It takes two to tango: NAD+ and sirtuins in aging/longevity control - npj Aging.

Niacinamide will increase NAD (and thus sirtuins?) on the other hand it has been shown in some studies to lower sirtuins...
- Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

There's tons of studies showing protective effects of sirtuins but also some showing pro-cancer effects.

 

[Motorneuron]

@Mauritio I agree, NAD and Sirtuine are agonists to each other Methylene blue also seems to behave the same way... oxidation or reduction depends on individual Redox state.

 

[David PS]

Taking supplements to boost NAD+ may create other problems. Here is an example.


View: https://www.youtube.com/watch?v=rHqU3upDUig

 

[Mauritio]

Taking supplements to boost NAD+ may create other problems. Here is an example.


View: https://www.youtube.com/watch?v=rHqU3upDUig

Great video ! Which makes the low dose nicotine even more interesting ,since it focuses on NAMPT.

 

[Elie]

Great video ! Which makes the low dose nicotine even more interesting ,since it focuses on NAMPT.

Is it known if there is anything that increases NAMPT?

 

[Highserotonin90]

@Elie Maybe I'm getting confused but should it be B1, folate and B3 itself? regarding SIRTs, if a subject has a chronic pathology perhaps the SIRTs are over-regulated and you would need tons of niacin (in fact 150mg/kg in vivo is suggested in Cancer cachexia) to have sufficient NAD+ while the niacinamide slows down SIRT and it guarantees NAD+ and recycling again... what do you think?

 

[Highserotonin90]

@Elie look

 

[Elie]

@Elie look

Great chart. Where did you get it from?
Yes, Thank you. I saw somewhere elsewhere on the forum that Rutin, Quercetin help replenish NAMPT (and I think ECGC was on that list too).
Also, alpha lipoic acid helps restore NADH to NAD+
I got to figure out the right combo for my aging 50 y.o.+ body

 

[Ismail]

Great chart. Where did you get it from?
Yes, Thank you. I saw somewhere elsewhere on the forum that Rutin, Quercetin help replenish NAMPT (and I think ECGC was on that list too).
Also, alpha lipoic acid helps restore NADH to NAD+
I got to figure out the right combo for my aging 50 y.o.+ body

Nichola Conlon speaks about this in nearly every video she has done promoting her product, here’s one example:


View: https://youtu.be/Fp5ZwOUVHkA?si=gmZX_viB1lQYlv12


There’s a very good thread on this forum which @David PS brought to my attention, however I cannot find it, it expounds upon what you have mentioned as well as other things related to NAD, CD38 etc.

 

[Elie]

Nichola Conlon speaks about this in nearly every video she has done promoting her product, here’s one example:


View: https://youtu.be/Fp5ZwOUVHkA?si=gmZX_viB1lQYlv12


There’s a very good thread on this forum which @David PS brought to my attention, however I cannot find it, it expounds upon what you have mentioned as well as other things related to NAD, CD38 etc.

Yes, thank you.

 

[David PS]

Nichola Conlon speaks about this in nearly every video she has done promoting her product, here’s one example:

View: https://youtu.be/Fp5ZwOUVHkA?si=gmZX_viB1lQYlv12


There’s a very good thread on this forum which @David PS brought to my attention, however I cannot find it, it expounds upon what you have mentioned as well as other things related to NAD, CD38 etc.

Thanks for the kind words about the thread.

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism Highlights •CD38 levels increase in tissues with age and correlate with NAD decline •NAD and mitochondrial function are preserved in old CD38 knockout mice •CD38 metabolizes NMN in vivo and...

raypeatforum.com

Here is another thread that may be helpful. For me, it boils down to switching from a dark roast coffee to a light roast.

Trigonelline - an NAD+ precursor with muscle longevity benefits across species

Trigonelline is an alkaloid is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3). It is a product of niacin metabolism that is excreted in urine of mammals. Trigonelline is lower in muscle with the age-related progressive loss of muscle mass and strength...

raypeatforum.com