High Rates Of Muscle Glycogen Resynthesis After Exhaustive Exercise When Carbohydrate Is Coingested


Jan 6, 2015

We determined the effect of coingestion of caffeine (Caff) with carbohydrate (CHO) on rates of muscle glycogen resynthesis during recovery from exhaustive exercise in seven trained subjects who completed two experimental trials in a randomized, double-blind crossover design. The evening before an experiment subjects performed intermittent exhaustive cycling and then consumed a low-CHO meal. The next morning subjects rode until volitional fatigue. On completion of this ride subjects consumed either CHO [4 g/kg body mass (BM)] or the same amount of CHO + Caff (8 mg/kg BM) during 4 h of passive recovery. Muscle biopsies and blood samples were taken at regular intervals throughout recovery. Muscle glycogen levels were similar at exhaustion [ approximately 75 mmol/kg dry wt (dw)] and increased by a similar amount ( approximately 80%) after 1 h of recovery (133 +/- 37.8 vs. 149 +/- 48 mmol/kg dw for CHO and Caff, respectively). After 4 h of recovery Caff resulted in higher glycogen accumulation (313 +/- 69 vs. 234 +/- 50 mmol/kg dw, P < 0.001). Accordingly, the overall rate of resynthesis for the 4-h recovery period was 66% higher in Caff compared with CHO (57.7 +/- 18.5 vs. 38.0 +/- 7.7 mmol x kg dw(-1) x h(-1), P < 0.05). After 1 h of recovery plasma Caff levels had increased to 31 +/- 11 microM (P < 0.001) and at the end of the recovery reached 77 +/- 11 microM (P < 0.001) with Caff. Phosphorylation of CaMK(Thr286) was similar after exercise and after 1 h of recovery, but after 4 h CaMK(Thr286) phosphorylation was higher in Caff than CHO (P < 0.05). Phosphorylation of AMP-activated protein kinase (AMPK)(Thr172) and Akt(Ser473) was similar for both treatments at all time points. We provide the first evidence that in trained subjects coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared with consumption of CHO alone.


May 30, 2015
Austin, TX
With that much caffeine and exercise in one sitting I'd be out of glycogen in about 2 minutes
Similar threads
Thread starter Title Forum Replies Date
Doludolu Switching from low carb | keto | carnivore experimentation back to High-carb. Tips for safe metabolic return ? Diet 3
ecstatichamster If you can buy a high altitude tent is that good as living at altitude Altitude, Bag Breathing, CO2, Light, Weather 5
H Effects of Physical Activity at High Altitude on Hormonal Profiles in Foreign Trekkers and Indigenous Nepalese Porters Scientific Studies 0
M Low or high stomach acid ? How to tell? Digestion 4
M Addressing Hair Loss and High Calcium Intake Hair & Nails 7
M Bile deficiency / Gilbert syndrome (chronic too high bilirubin) Ask For Help or Advice 0
G Epstein-Barr and Cytomegalovirus high chrnio Viruses, Parasites, Fungus, Vaccines 3
S High Test but Suddenly Low free Test? Blood Work, Labs 7
C Is high-dose Thiamine therapy safe? Vitamins 13
youngsinatra Can High Vitamin D Compensate Lower Dietary Calcium? Ask For Help or Advice 4
J Any idea why my blood pressure could be high? Diet 3
M Normal/High Testosterone but low DHEA-S Blood Work, Labs 14
A High-carb diet vs supplements for reducing cortisol Diet 3
Marine Is possible to have and mantain a. high sex drive everyday? Male Issues 29
M High calcium ? Ask For Help or Advice 0
J High triglycerides, high cholesterol (LDL), mildly elevated AST Blood Work, Labs 4
P High dose vitamin k2 around 45mg makes vericocele vanish Male Issues 7
IVILA What explains high estrone but low estradiol? Ask For Help or Advice 5
T High Lipoprotein A. Anyone else? Blood Work, Labs 8
R Safest medication to treat high blood pressure? Ask For Help or Advice 53
Hgreen56 High sugar consumption could cause the body to become unable to regulate androgen levels? Hormones 21
Hans The high sugar model did not prove to be a good model of obesity Scientific Studies 1
C Vitamin D, daily low dose or infrequent high dose? Vitamins 11
RWilly Baking Powder - a surprising amount of calcium - high calcium to phosphorus ratio Miscellaneous Health Discussions 6
F Can high reverse T3 cause acummulation of the exogenous thyroid hormone in the body? Ask For Help or Advice 3
D Vitamin D Always High! Blood Work, Labs 13
A The safety of high salt diet? Ask For Help or Advice 10
Sam321 How do you determine if you have high nitric oxide? Ask For Help or Advice 2
charlie Solid High-Carbon Steel For Cooking? What Say You? Cookware, Microwave 24
D High salt intake caused metabolic acidosis Metabolism 83
Jam Applying Peat Principles To Low-Carb High-Saturated Fat: Incredible Results Discussing Dietary Models 136
G My high estrogen won't drop. Help Ask For Help or Advice 27
M Low carb high fat (pre T3) VS high carb low fat (taking 3 drops of tyronene upon waking) Logs 7
Sam321 Havent slept in a day. How to turn off high pulse and adrenaline. Ask For Help or Advice 45
Mr Joe Combo High Dose (B1 + Cypro + B3) + T3 for recovery Mental Issues 12
Mito Deaths from alcohol hit record high during 2020 Miscellaneous Health Discussions 6
charlie An Open-Label Pilot Study With High-Dose Thiamine in Parkinson's Disease Scientific Studies 5
R High dose taurine long-term 3-5G per day? Taurine 2
W High DHEA but low testosterone? Blood Work, Labs 3
5 Chronic, High-Dose Androgen Use and Adrenal Suppression Male Issues 0
deliciousfruit I Think High Serotonin Is Holding Me Back Ask For Help or Advice 10
Vileplume High Sedentary Heart Rate and Hot Flashes (Guy) Heart, Heart Rate, Blood Pressure 25
J High sugar diet has wrecked my teeth, Decay and dentist say i need filling Oral Health 42
Advocate2021 High Cholesterol and High Thyroid on Bloodwork- Confused Blood Work, Labs 27
N Do you need extra calcium with high dose k2? K 16
N Extremely High Cortisol Ask For Help or Advice 4
youngsinatra High Dose Niacinamide Self-Experiment. Experiments 29
haidut Heart attack survivors have high stress (cortisol/adrenaline) hypersensitivity, low androgens Scientific Studies 2
M High testosterone low libido Diet 23
J Levo gives me high BP- is anyone using small doses of T3 with meals in lieu of levo? Supplements, Pharmaceutical Drugs 2

Similar threads