- Jan 15, 2016
If anyone has taken this amount, please let me know any side effects or good effects you experienced. Thanks
I routinely took that amount when I discovered orthomolecular medecine. At least 3g niacinamide per day along with 1g+ Vitamin B6. Actually I probably took niacin in those days, and stopped because the flush was really not enjoyable. No other side effects and some pretty clear
I’m not doing that anymore, but I think it’s pretty clear that ‘’unphysiological” doses of vitamins and minerals can be therapeutic. Orthomolecular medecine researchers even coined the term ‘dependency’ instead of mere deficiency.
What issues were you trying to resolve, if you may?
That sounds like issue with blood sugar, as niacinamide enhances glucose oxidation. Sometimes at night my heart starts beating faster than normal and I can't seem to relax enough to fall asleep. Eating something resolves it.Im the one rare case I’ve come across so far.
If I take more than 50mg of niacinamide in a day, I sleep terrible. My heart rate will be pumping like crazy all through the night.
There is no other supplement that ramps my metabolism so much where I do not enjoy it.
I find it interesting that people can feel so calm and relaxed from it as it does the complete opposite to me.
That sounds like issue with blood sugar, as niacinamide enhances glucose oxidation. Sometimes at night my heart starts beating faster than normal and I can't seem to relax enough to fall asleep. Eating something resolves it.
Niacinamide "uses up" the SAMe in methylation and this can increase homocysteine, histamine, estrogen, dopamine, etc. So with some with already high dopamine, histamine, serotonin, etc., niacinamide might make them feel worse through that mechanism.@Hans has pointed out in a different discussion that I may be experiencing an issue with the inefficiency of glucolysis vs oxidative phosphorylation would this explain the problem @Velve921 is seeing?
I ask because I took 150mg niacinamide last night before bed and had one of the worst night's sleep I have had in a couple of months.
Niacinamide "uses up" the SAMe in methylation and this can increase homocysteine, histamine, estrogen, dopamine, etc. So with some with already high dopamine, histamine, serotonin, etc., niacinamide might make them feel worse through that mechanism.
Have you tried a 1:1 ratio as well, or did experimentation lead you to that ratio?I should have mentioned my 500mg niacinamide over the course of a day, is supported by 3x 500mg trimethylglycine (TMG) to balance methylation since niacin is a methyl sink. Otherwise, after a few weeks on just niacinamide, I become the walking dead.
Have you tried a 1:1 ratio as well, or did experimentation lead you to that ratio?
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