Concussion

[Morten]

Has anyone a supplement suggestion for concussion, besides allready established behavior like good sleep, no blue light, calmness ect?

 

[cs3000]

maybe things that increase BDNF (that arent themselves damaging) (in balanced doses)
treatment of traumatic brain injury, several of the studies showed promising results and there is evidence of a positive correlation between increased BDNF expression and improved functional outcome
& progesterone might be worth looking into

Need for good myelin repair after injury,
so u especially want good copper & thyroid function. probably high vit b5 intake also

Myelin and traumatic brain injury: The copper deficiency hypothesis

Nearly two million people suffer traumatic brain injury in the US each year. These injuries alter adversely the metabolism of myelin, a major lipid ma…

www.sciencedirect.com

The concentration of myelin basic protein increases markedly in cerebrospinal fluid of infants with acute head injury [3]. Head trauma can produce demyelination [4]. Cognitively impaired former football players had abnormalities of white matter on magnetic resonance imaging of brain

(increased copper intake in brain area after injury, trying to repair) Assessment of Traumatic Brain Injury by Increased 64Cu Uptake on 64CuCl2 PET/CT

Copper is a nutritional trace element required for cell proliferation and wound repair. Results: At 24 h after intravenous injection of the tracer, uptake was significantly higher in the injured cortex of TBI mice (1.15 ± 0.53 percentage injected dose per gram of tissue [%ID/g]) than in the uninjured cortex of mice without TBI (0.53 ± 0.07 %ID/g, P = 0.027). Conclusion: Overall, the data suggest that increased 64Cu uptake in traumatized brain tissues holds potential as a new biomarker for noninvasive assessment of TBI with 64CuCl2 PET/CT.

 

[Morten]

maybe things that increase BDNF (that arent themselves damaging) (in balanced doses)
treatment of traumatic brain injury, several of the studies showed promising results and there is evidence of a positive correlation between increased BDNF expression and improved functional outcome
& progesterone might be worth looking into

Need for good myelin repair after injury,
so u especially want good copper & thyroid function. probably high vit b5 intake also

Myelin and traumatic brain injury: The copper deficiency hypothesis

Nearly two million people suffer traumatic brain injury in the US each year. These injuries alter adversely the metabolism of myelin, a major lipid ma…

www.sciencedirect.com

(increased copper intake in brain area after injury, trying to repair) Assessment of Traumatic Brain Injury by Increased 64Cu Uptake on 64CuCl2 PET/CT

Thanks cs, i will look closer...

 

[Peatful]

Concussion Treatment

Happy New Year All... unfortunately my wife slipped with socks on a slippery staircase and fell about 15 steps and was unconscious for about 3 minutes. Since then she has had problems with verbal fluency due to this concussion. I search on Ray Peat Forum but no discussion of concussion...

raypeatforum.com

 

[Morten]

Concussion Treatment

Happy New Year All... unfortunately my wife slipped with socks on a slippery staircase and fell about 15 steps and was unconscious for about 3 minutes. Since then she has had problems with verbal fluency due to this concussion. I search on Ray Peat Forum but no discussion of concussion...

raypeatforum.com

Grateful, thanks peatful

 

[Peatful]

Grateful, thanks peatful

Yw

 

[Elie]

Homeopathic arnica
Rhodiola rosea

 

[Morten]

Homeopathic arnica
Rhodiola rosea

Thanks so much

 

[lamassu]

keeping inflammation low, good thyroid function, progesterone, magnesium and calcium

 

[ecstatichamster]

Minocycline is highly protective against traumatic brain injury.

Acute Minocycline Treatment Mitigates the Symptoms of Mild Blast-Induced Traumatic Brain Injury

Mild traumatic brain injury (mTBI) represents a significant challenge for the civilian and military health care systems due to its high prevalence and overall complexity. Our earlier works showed evidence of neuroinflammation, a late onset of neurobehavioral changes, and lasting memory...

www.frontiersin.org

Mild traumatic brain injury (mTBI) represents a significant challenge for the civilian and military health care systems due to its high prevalence and overall complexity.

Our earlier works showed evidence of neuroinflammation, a late onset of neurobehavioral changes, and lasting memory impairment in a rat model of mild blast-induced TBI (mbTBI).

The aim of our present study was to determine whether acute treatment with the non-steroidal anti-inflammatory drug minocycline (Minocin®) can mitigate the neurobehavioral abnormalities associated with mbTBI, Furthermore, we aimed to assess the effects of the treatment on select inflammatory, vascular, neuronal, and glial markers in sera and in brain regions associated with anxiety and memory (amygdala, prefrontal cortex, ventral, and dorsal hippocampus) following the termination (51 days post-injury) of the experiment.

Four hours after a single exposure to mild blast overpressure or sham conditions, we treated animals with a daily dose of minocycline (50 mg/kg) or physiological saline (vehicle) for four consecutive days. At 8 and 45 days post-injury, we tested animals for locomotion, anxiety, and spatial memory. Injured animals exhibited significantly impaired memory and increased anxiety especially at the later testing time point.

Conversely, injured and minocycline treated rats’ performance was practically identical to control (sham) animals in the open field, elevated plus maze, and Barnes maze. Protein analyses of sera and brain regions showed significantly elevated levels of all of the measured biomarkers (except VEGF) in injured and untreated rats. Importantly, minocycline treatment normalized serum and tissue levels of the majority of the selected inflammatory, vascular, neuronal, and glial markers. In summary, acute minocycline treatment appears to prevent the development of neurobehavioral abnormalities likely through mitigating the molecular pathologies of the injury in an experimental model of mbTBI.

 

[Morten]

Great interesting study!

 

[Morten]

keeping inflammation low, good thyroid function, progesterone, magnesium and calcium

Thank lamassu

 

[jdrop]

Has anyone a supplement suggestion for concussion, besides allready established behavior like good sleep, no blue light, calmness ect?

Red light treatment

 

[Rinse & rePeat]

“A review of experimental TBI studies indicates that progesterone infusion results in reduced neuronal loss, enhanced remyelination, improved functional recovery, and an overall decrease in cerebral edema.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025750/#:~:text=A%20review%20of%20experimental%20TBI,overall%20decrease%20in%20cerebral%20edema.

 

[Morten]

“A review of experimental TBI studies indicates that progesterone infusion results in reduced neuronal loss, enhanced remyelination, improved functional recovery, and an overall decrease in cerebral edema.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025750/#:~:text=A%20review%20of%20experimental%20TBI,overall%20decrease%20in%20cerebral%20edema.

Well, that says it all. Just received progest-E would you bwt know approx dose for a 135 pound female?

 

[Morten]

Red light treatment

 

[Rinse & rePeat]

Well, that says it all. Just received progest-E would you bwt know approx dose for a 135 pound female?

Ray Peat says you can’t overdose on the stuff, besides it having an anesthesia effect. More is required if applying on the skin and less if on the gums, and with the gums it goes quicker into the blood stream.

 

[Morten]

Ray Peat says you can’t overdose on the stuff, besides it having an anesthesia effect. More is required if applying on the skin and less if on the gums, and with the gums it goes quicker into the blood stream.

Super, thanks. Easy to apply....

 

[Rinse & rePeat]

Super, thanks. Easy to apply....

It’s good thankful stuff!

 

[Morten]

Ri@Rinse & rePeat
Any comments on this tread?

Excessive Fructose is Poison & Burden To The Liver & Mitochondria

Forum memberr @tyw figured this out long ago, fructose is poison. Sure wish I would have listened to @tyw back then. The liver sees it as a toxin and clears it as such while being a burden at the same time. So table sugar is poison, Mexican coke is poison, ice cream poison, and on and on...

raypeatforum.com