Can Pregnenlone Be Suppressive To The Hpta Axis

[Hairlosssucks]

In high amounts would it suppress you?

Also what is the recommended amount when starting supplementation with preg

 

[Blaze]

In high amounts would it suppress you?

Also what is the recommended amount when starting supplementation with preg

It's more complicated than just dosage. Both low and high doses have been well tolerated by many. I think of pregnenolone as a substrate used to manufacture a multitude of the downstream hormones. So any positive or negative effect it has would depend on what your body produces from it and vary greatly from individual to individual.

--------------------------------------------------Cholesterol-------------------------------------------------------------------------
--------------------------------------------------Pregnenolone----------------------------------------------------------------------
---------------------Progesterone____________________________________________________DHEA----------------------------------------
------------------------Cortisol________________________________________________Testosterone or Esterol-----------------------------

One needs to be sure to manage stress prior to supplementing pregnenolone. Or it may have an undesired effect.
For example, if a person is under great stress , the "pregnenolone steal" might serve just to rob pregnenolone being utilized for normal dhea production and use it to overproduce cortisol.

Some thrive on smaller doses. I seem to tolerate very large doses with no negative issues. But, again , this effect varies a lot from person to person. If you experience a benefit , and helps to balance your hormones , the use it. If not, discontinue. As to dose, you will have to experiment to see what works for you.

Since the HPTA axis serves to regulate / modulate the stress and inflammatory response , it's output will be affected by an overproduction of cortisol for sure.

So, Cholesterol is used to produce Pregnenolone (you can naturally produce no more than around 10mg each day I think) , which is then used to make all the downstream hormones Progesterone, DHEA , Cortisol , Testosterone , Esterol. Supplementation , in theory, gives your body access to more pregnenolone than it can naturally produce in a 24 hour period which can be used by the body to produce more of what downstream hormones it needs. Probably much safer than HRT.