energyandstruct
Member
- Joined
- Nov 27, 2017
- Messages
- 960
i had good results with the BCAA and tyrosine combo but got pretty intense diarrhea the fourth time I did it (sorry for TMI but relevant symptom). I wonder if this is a common symptom?Yep, BCAA are double-edged sword - they deplete whatever aromatic amino acid is in dearth. If both phenylalanine/tyrosine and tyrptophan are in dearth (i.e. taking BCAA on their own) then BCAA will deplete both serotonin and dopamine. This is probably the reason for their mixed effect on human trials on fatigue. However, this study recognized this fact and remediated it by adding 1,000mg - 1,500mg tyrosine to the 3g of BCAA. If you click on the author's name "Fernstrom" you will see him doing studies on BCAA and neurotransmitter depletion going back 20 years. His studies is what got me experimenting with BCAA, tyrosine, phenylalanine, etc several years ago.
Oral branched-chain amino acid supplements that reduce brain serotonin during exercise in rats also lower brain catecholamines. - PubMed - NCBI
Link to author's other amino acid studies:
Fernstrom JD - PubMed - NCBI[Author]&cauthor=true&cauthor_uid=23904096