Conditionally Essential Amino Acids: Glycine And Arginine

[Nicholas]

regarding Lysine overdosage:

http://www.ncbi.nlm.nih.gov/pubmed/15204731

"A Lys-related drop in serum concentration and an increase in urine excretion of chlorides was a compensatory reaction to the ingested hydrochloride. No functional, biochemical, or histological changes in renal function were found. The no-observed-adverse-effect level (NOAEL) for Lys was estimated at 5.0% for both genders (male, 3.36 +/- 0.12 g/kg/day; female, 3.99 +/- 0.28 g/kg/day)."

regarding Taurine toxicity:

http://www.ncbi.nlm.nih.gov/pubmed/18325648

"The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d"

regarding the antagonistic relationship of arginine and lysine:

"Arginine is a conditionally essential amino acid, meaning that whether or not it is required to be healthy is conditional on the health status or life cycle of the individual." - wikipedia

regarding lysine suppressing growth hormone in chicks, and arginine (or glycine) increasing it:

http://jn.nutrition.org/content/104/9/1127.full.pdf

glycine can increase growth hormone: http://www.ncbi.nlm.nih.gov/pubmed/23615880

Glycine, like arginine, is a conditionally essential amino acid but also seems to show far more benefit (and even different benefit) than arginine.

all of these points add up still to lysine being a low-risk supplement (along with Taurine, though not a true amino acid)....especially in situations where arginine depletion (and therefore GH and NO) is needed based on certain conditions somebody may be dealing with. also because Lysine is an essential amino acid.

all this info. and other info shared in this forum also points to glycine and arginine being higher risk supplements based on the conditions of the person, while glycine seems lower risk than arginine supplementation.

Growth hormone, NO, etc. are not evils to just assume that you need to lower. While interestingly, Lysine...an essential amino acid, does antagonize growth hormone and NO (Taurine does the same, but is not a true amino acid). If i'm mistaken, please share your perceptions and any other insight.

 

[hmac]

Interesting, thanks.
Could you explain why Taurine isn't an amino acid?

 

[charlie]

Thank you.

 

[NathanK]

According to an Amazon review of Bulk Supps Ornithine, "Dr Oz show said that the Glycine, Ornithine, Arginine, and Lysine amino acids raise grown hormone levels by approximately 600%". I haven't had time, but was going to look into that claim.

 

[DaveFoster]

regarding Lysine overdosage:

Thirteen-week oral toxicity study of L-lysine hydrochloride in rats. - PubMed - NCBI

"A Lys-related drop in serum concentration and an increase in urine excretion of chlorides was a compensatory reaction to the ingested hydrochloride. No functional, biochemical, or histological changes in renal function were found. The no-observed-adverse-effect level (NOAEL) for Lys was estimated at 5.0% for both genders (male, 3.36 +/- 0.12 g/kg/day; female, 3.99 +/- 0.28 g/kg/day)."

Interesting how it's more for females, as males are heavier due to muscle mass.

So that's 268 grams of lysine for an 80 kg man.

 

[Giraffe]

all this info. and other info shared in this forum also points to glycine and arginine being higher risk supplements based on the conditions of the person, while glycine seems lower risk than arginine supplementation.

Peat doesn't recommend supplementing arginine: it's dangerous, stimulates cancer growth.

Caller: Did you say that l-arginine was bad? I'd heard that was supposed to be good for you but I'm not sure what it's supposed to do?
HD: Dr Peat, arginine you mentioned a minute ago..
Caller: ...And is there a difference between arginine and l-arginine?
RP: Yes the internet is just swamped with advertisements for ways to supplement arginine; l-arginine is just the natural amino acid, but if you get more than you need, it will increase your tendency to over-produce nitric oxide and too much tryptophan happens to boost that. And possibly by increasing serotonin but it's very important to keep your amino acids in a good balance, especially avoiding too much cysteine, tryptophan, methionine and arginine.
Caller: So you don't recommend taking an l-arginine supplement?
RP: No, I think it's very dangerous.

Nitric Oxide - KMUD 2014-11-21

RP: Ya, I just recently heard about a doctor who treats cancer patients with intravenous arginine. Just before I heard about him, I had been reading way back to the 1940s, people discovered that arginine stimulate cancer growth, and starvation or reduction of arginine stops cancer growth. Through the 50s and 60s continuing - it's being picked up again just recently - methods to stop the conversion of arginine to nitric oxide, or to reduce the availability of arginine, it's being investigated again as a way to cure cancer. So, there are these two very opposite things going on. One is nitric oxide is being proposed to cure cancer; or suppressing nitric oxide - it's demonstrated to stop the growth of cancer.

Digestion and Emotion - KMUD, 2015-01-02

 

[Frankdee20]

regarding Lysine overdosage:

Thirteen-week oral toxicity study of L-lysine hydrochloride in rats. - PubMed - NCBI

"A Lys-related drop in serum concentration and an increase in urine excretion of chlorides was a compensatory reaction to the ingested hydrochloride. No functional, biochemical, or histological changes in renal function were found. The no-observed-adverse-effect level (NOAEL) for Lys was estimated at 5.0% for both genders (male, 3.36 +/- 0.12 g/kg/day; female, 3.99 +/- 0.28 g/kg/day)."

regarding Taurine toxicity:

Risk assessment for the amino acids taurine, L-glutamine and L-arginine. - PubMed - NCBI

"The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d"

regarding the antagonistic relationship of arginine and lysine:

"Arginine is a conditionally essential amino acid, meaning that whether or not it is required to be healthy is conditional on the health status or life cycle of the individual." - wikipedia

regarding lysine suppressing growth hormone in chicks, and arginine (or glycine) increasing it:

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glycine can increase growth hormone: Glycine metabolism in animals and humans: implications for nutrition and health. - PubMed - NCBI

Glycine, like arginine, is a conditionally essential amino acid but also seems to show far more benefit (and even different benefit) than arginine.

all of these points add up still to lysine being a low-risk supplement (along with Taurine, though not a true amino acid)....especially in situations where arginine depletion (and therefore GH and NO) is needed based on certain conditions somebody may be dealing with. also because Lysine is an essential amino acid.

all this info. and other info shared in this forum also points to glycine and arginine being higher risk supplements based on the conditions of the person, while glycine seems lower risk than arginine supplementation.

Growth hormone, NO, etc. are not evils to just assume that you need to lower. While interestingly, Lysine...an essential amino acid, does antagonize growth hormone and NO (Taurine does the same, but is not a true amino acid). If i'm mistaken, please share your perceptions and any other insight.

I want to buy life insurance

 

[ReSTART]

Arginine raises nitric oxide