What you can do about quarantine induced social isolation and depression : Allopregnanolone!

[Razvan]

An

My 5adhp product arrived as well but I noticed that drops barely get out of the bottle like it's almost empty ,is this normal ? First time trying idealabs. I'm trying it today with T3,I think I will order pansterone as well for the dhea topical effect.

Anyways I think I did 3 drops if something came out (i barely saw the drops Idk why)of 5adhp and i saw immediately an effect of sedation and i got out with my girlfriend into the city centre and i was very mellow and chilled i also felt that DHT effect of analysing every people around me and giving them eye contact(females were looking at me everytime ,my gf got jealous) but i had also not interest on socializing too much like the no libido effect of antiestrogen, when I have low estrogen i don't want to speak and i prefer to listen. Now I took 3 mg of T3 to spice things up a bit.

 

[Mauritio]

My 5adhp product arrived as well but I noticed that drops barely get out of the bottle like it's almost empty ,is this normal ? First time trying idealabs. I'm trying it today with T3,I think I will order pansterone as well for the dhea topical effect.

I had that issue with kuinone . Try sticking a needle in there . I literally had to create a new whole for kuinone so drops would come out .

 

[Razvan]

Oh thanks bro, will try!!are you from spain?

 

[Mauritio]

Oh thanks bro, will try!!are you from spain?

You're welcome . No I'm from Germany. Are you from Spain?

 

[haidut]

My 5adhp product arrived as well but I noticed that drops barely get out of the bottle like it's almost empty ,is this normal ? First time trying idealabs. I'm trying it today with T3,I think I will order pansterone as well for the dhea topical effect.

The product is normally viscous due to the tocopherols, the saturated nature of the steroid, and the SFA/OA fats. So, it needs to be kept at temps of at least 70 degrees F, so it can easily dispense. It will still dispense at lower temps but the drops will come out more slowly.
Not sure what you mean by bottle almost empty. It is not supposed to be full to the top, but just to the line where the bottle neck starts to become narrower. That is the mark of 10ml of liquid for that bottle. The bottle itself can handle probably up to 17ml and this is why it is not full.

 

[haidut]

This is just a heads up to everyone strugglin with depression by itself and especially depression caused by social isolation and a hopeless situation, that many people find them selves in .
Social isolation does have an effect on the human body and especially brain ! There's a few studies showing that social isolation decreases especially allopregnanolone in the brain , which is a cause for depression itself .

"We demonstrate that there is a consistent decrease in allopregnanolone levels in limbic brain areas in rodents submitted to stress-induced models of depression, such as social isolation and chronic unpredictable stress. Further, both the drug-induced upregulation of allopregnanolone or its direct administration reduce depressive-like behaviors in models such as the forced swim test. "

The role of allopregnanolone in depressive-like behaviors: Focus on neurotrophic proteins

Allopregnanolone (3α,5α-tetrahydroprogesterone; pharmaceutical formulation: brexanolone) is a neurosteroid that has recently been approved for the tre…

www.sciencedirect.com

AFAIK you can't buy allopregnanolone as a steroid , not even on the black market . It is approved for post partum depression ,but that will cause at least 34 000 $ if you dont have insurance (classic pharma move), so we need different ways to raise it.

F.D.A. Approves First Drug for Postpartum Depression (Published 2019)

The medication works quickly, within 48 hours. But it’s an expensive infusion and requires a stay in a medical center.

www.nytimes.com

I just recently posted a studie on a chinese herbal formula called Jia Wei Xiao Yao, that seems to be pretty effective at raising allopregnanolone. It has a long history of treating depression ,anxiety and PMS in TCM.

Autism caused by low allopregnenolone , chinese herb can treat

This study shows that the chinese herbal formula Kami-shoyo-san, also known as Jia Wei Xiao Yao Pian, can treat autism / reverse autistic behaviors in mice . First they show that autistic behaviour was caused by a decrease in allopregnenolone. Then they gave mice the herbal formula and...

raypeatforum.com

There's also still idelabs product 5a DHP which converts into allopregnanolone in the body.

5α-DHP - Liquid 5α-Dihydroprogesterone For Lab/R&D

****DISCONTINUED****DISCONTINUED****DISCONTINUED**** Replaced by allopregnanolone, which is a direct metabolite of 5α-Dihydroprogesterone (5α-DHP). https://raypeatforum.com/community/threads/allop-liquid-allopregnanolone-for-lab-r-d.41055/...

raypeatforum.com

Lastly theres also progesterone and pregnenolone, which can convert into allo downstream. I dont know how much of it will end up as allo ,though. Probably very individual, depending on your enzymes .

Interestingly enough, pregnenolone (precursor for allopregnanolone) has been studied precisely as a treatment for loneliness. The studies are pretty recent, so it is quite a coincidence to have them appear just before the "pandemic".

Pregnenolone As A Treatment For Loneliness

I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...

raypeatforum.com

Pregnenolone Advances As A Treatment For Loneliness In Humans

A few years ago, I posted a thread on the possibility of using pregnenolone as a treatment for loneliness in humans. Pregnenolone As A Treatment For Loneliness At the time, the studies were mostly based on animal models and a small pilot human study. It seems that the results were promising...

raypeatforum.com

 

[Mauritio]

Interestingly enough, pregnenolone (precursor for allopregnanolone) has been studied precisely as a treatment for loneliness. The studies are pretty recent, so it is quite a coincidence to have them appear just before the "pandemic".

Pregnenolone As A Treatment For Loneliness

I touched upon this idea/topic in some of my other posts, and just like those other posts, I would like to emphasize here that I am not suggesting steroid supplementation as a substitute for social interaction. The purpose of this post if to provide some insight on the biochemical effects of...

raypeatforum.com

Pregnenolone Advances As A Treatment For Loneliness In Humans

A few years ago, I posted a thread on the possibility of using pregnenolone as a treatment for loneliness in humans. Pregnenolone As A Treatment For Loneliness At the time, the studies were mostly based on animal models and a small pilot human study. It seems that the results were promising...

raypeatforum.com

Why would they push something that works so well ? Especially considering that pregnenolone wouldnt just cure depression/loneliness but possibly many other things ,which would decrease pharma's profit .

 

[Velve921]

My 5adhp product arrived as well but I noticed that drops barely get out of the bottle like it's almost empty ,is this normal ? First time trying idealabs. I'm trying it today with T3,I think I will order pansterone as well for the dhea topical effect.

Yes for me I hav to squeeze hard as well.

 

[Razvan]

The product is normally viscous due to the tocopherols, the saturated nature of the steroid, and the SFA/OA fats. So, it needs to be kept at temps of at least 70 degrees F, so it can easily dispense. It will still dispense at lower temps but the drops will come out more slowly.
Not sure what you mean by bottle almost empty. It is not supposed to be full to the top, but just to the line where the bottle neck starts to become narrower. That is the mark of 10ml of liquid for that bottle. The bottle itself can handle probably up to 17ml and this is why it is not full.

Thank you Haidut ,by like it's empty i was referring that I have to squeeze very hard to take it ,but now I understand, thank you for the explanation

 

[Sam321]

Reaching out to friends or trying to make new friends might be a better solution for isolation and depression than preg if possible.

 

[Razvan]

The product is normally viscous due to the tocopherols, the saturated nature of the steroid, and the SFA/OA fats. So, it needs to be kept at temps of at least 70 degrees F, so it can easily dispense. It will still dispense at lower temps but the drops will come out more slowly.
Not sure what you mean by bottle almost empty. It is not supposed to be full to the top, but just to the line where the bottle neck starts to become narrower. That is the mark of 10ml of liquid for that bottle. The bottle itself can handle probably up to 17ml and this is why it is not full.

@haidut Why does 5a-dhp product makes me so sedated and lethargic.What is the action behind it? I've tried it now for 3-4 days and i think it has a very antiestrogenic action because it lowers my crazy libido,but it makes me very sedated,all I want to do is stay alone and watch interesting things and don't get bothered,it is similar with progesterone but progesterone makes me feel high and euphoric. I will now experiment with a higher dosage (15mg) as you said that got you more of a pro androgenic feeling.

 

[Mauritio]

@haidut Why does 5a-dhp product makes me so sedated and lethargic.What is the action behind it? I've tried it now for 3-4 days and i think it has a very antiestrogenic action because it lowers my crazy libido,but it makes me very sedated,all I want to do is stay alone and watch interesting things and don't get bothered,it is similar with progesterone but progesterone makes me feel high and euphoric. I will now experiment with a higher dosage (15mg) as you said that got you more of a pro androgenic feeling.

I thinks it's too much GABA agonism . Thats exactly how too much GABA feels like:too relaxed ,to the point where you're almost sedated . Depersonalization is also a side effect of too much GABA . It feels like I'm less empathetic in a way ,because I simply dont care . But never had that with 5adhp .

 

[Razvan]

I thinks it's too much GABA agonism . Thats exactly how too much GABA feels like:too relaxed ,to the point where you're almost sedated . Depersonalization is also a side effect of too much GABA . It feels like I'm less empathetic in a way ,because I simply dont care . But never had that with 5adhp .

Yes,less less empathic and somehow dumber in a way. But not sleepy like you want to sleep,strange.

 

[Razvan]

I thinks it's too much GABA agonism . Thats exactly how too much GABA feels like:too relaxed ,to the point where you're almost sedated . Depersonalization is also a side effect of too much GABA . It feels like I'm less empathetic in a way ,because I simply dont care . But never had that with 5adhp .

I think if I will drink some vodka feeling like this i will pass out in 5 minutes.

 

[Razvan]

I thinks it's too much GABA agonism . Thats exactly how too much GABA feels like:too relaxed ,to the point where you're almost sedated . Depersonalization is also a side effect of too much GABA . It feels like I'm less empathetic in a way ,because I simply dont care . But never had that with 5adhp .

From what things you've got this "too much gaba feeling"?

 

[Razvan]

You're welcome . No I'm from Germany. Are you from Spain?

I'm italian-romanian with greek grandparents and i move a long countries, i lived in france ,ireland,Italy,Spain,Greece,right now I'm in romania because there isn't self isolation here. I consider myself a man of world ahah.

 

[Mauritio]

From what things you've got this "too much gaba feeling"?

Just last week I tried ecklonia cava and it gave that feeling (it increases GABA) , i was also a bit moody ,but that might have been low blood sugar
There was something else but I cant remember what it was ...

 

[Mauritio]

I'm italian-romanian with greek grandparents and i move a long countries, i lived in france ,ireland,Italy,Spain,Greece,right now I'm in romania because there isn't self isolation here. I consider myself a man of world ahah.

Sounds like an interesting story , I'd like to here more at some point !
Hows living in Romania, it's quite cheap isnt it . I just heard today that Romania has way better internet than Germany for a fraction of the price ...

 

[Razvan]

Just last week I tried ecklonia cava and it gave that feeling (it increases GABA) , i was also a bit moody ,but that might have been low blood sugar
There was something else but I cant remember what it was ...

Yeah I get it....
Anyways tried 15 mg of 5a-dhp 2,5 hours ago and that feeling of can't focusing and extreme sedation is gone,I feel now very calm and libido is gone up which is interesting... Maybe some pathway conversation to DHT.. i don't know.Very strange chemical this 5a-dhp,need to experiment more to understand it better,very different effect from pregnenolone though.

 

[Mauritio]

Yeah I get it....
Anyways tried 15 mg of 5a-dhp 2,5 hours ago and that feeling of can't focusing and extreme sedation is gone,I feel now very calm and libido is gone up which is interesting... Maybe some pathway conversation to DHT.. i don't know.Very strange chemical this 5a-dhp,need to experiment more to understand it better,very different effect from pregnenolone though.

Yes very different feeling from pregnenolone , also depends a lot on how you take it. Preg taken topically gives a more androgenic reaction than given orally .
5adhp then again feels pretty different from preg .
I'm excited to try the herbal formula that raises allopregnanolone, let's see how that will feel !