Yeah, I only ever take it about 2-3 times a week, and only 400IU with some mixed Tocopherols. Interestingly, when I took the Unique - E (which is high GAMMA and 1:1 Alpha to GAMMA) I get the same effects from this Solgar brand (high Alpha). You are correct, it does antagonize Vitamin K-1, but I do not know about K2.
It maybe antagonizes K1 and alters K1 conversion to K2, so should be good if you take K2 itself. I couldn't notice any estrogen like effect from the thorne ultimate E. Not sure what a progesterone effect would feel like. Selenium and vitamin c also recycle the vitamin E. I read one person on here saying Ultimate E made them feel great while another said they didn't notice anything from it.