What Is Your Experience With K2 Megadosing?

[BigChad]

Yeah, I only ever take it about 2-3 times a week, and only 400IU with some mixed Tocopherols. Interestingly, when I took the Unique - E (which is high GAMMA and 1:1 Alpha to GAMMA) I get the same effects from this Solgar brand (high Alpha). You are correct, it does antagonize Vitamin K-1, but I do not know about K2.

It maybe antagonizes K1 and alters K1 conversion to K2, so should be good if you take K2 itself. I couldn't notice any estrogen like effect from the thorne ultimate E. Not sure what a progesterone effect would feel like. Selenium and vitamin c also recycle the vitamin E. I read one person on here saying Ultimate E made them feel great while another said they didn't notice anything from it.

 

[Frankdee20]

Any distinct benefits from Thorne - E ?

 

[BigChad]

Any distinct benefits from Thorne - E ?

None noted, but no estrogenic effects for me.

 

[baccheion]

Vitamin E interferes with absorption of vitamin K1 (but not K2 MK-4) and the actions of K2 MK-4. It's also said to lower conversion of K1 into K2 MK-4.

 

[BigChad]

Vitamin E interferes with absorption of vitamin K1 (but not K2) and the actions of K2.

so you basically need more K2 if supplementing E? how do you get around vitamin E interfering with actions of K2, is that something that can be resolved just by increasing K2 intake

 

[baccheion]

so you basically need more K2 if supplementing E? how do you get around vitamin E interfering with actions of K2, is that something that can be resolved just by increasing K2 intake

Most recommend taking them a few hours apart. I can usually tell when MK-4 is too low, as teeth no longer feel clean. On the other hand, that's for regular higher doses (ie, 1 mg).

 

[BigChad]

Most recommend taking them a few hours apart. I can usually tell when MK-4 is too low, as teeth no longer feel clean. On the other hand, that's for regular higher doses (ie, 1 mg).

what do you mean by "on the other hand that's for regular higher doses"?
if you take 1000mg mixed tocopherols 2x a week (of which 335mg are alpha, 335 are gamma), how much Mk4 would you need to counteract that

 

[baccheion]

what do you mean by "on the other hand that's for regular higher doses"?
if you take 1000mg mixed tocopherols 2x a week (of which 335mg are alpha, 335 are gamma), how much Mk4 would you need to counteract that

Take them separately. If not doing anything special with MK-4 (eg, zygomatic arch development), there's the indicator I mentioned above.

 

[ddjd]

@Arrade @Elkman @BigChad I completely agree that k2 mk4 increases shedding but I really think it reduces progression of Male pattern baldness in terms of long term effect.

 

[Homo Consumericus]

Has anyone megadosed K2 and achieved visible changes?

Like increased cheekbone volume or height gains?

What dosages were you using? What other supplements did you take?

I'm 3/4 through a Thorne MK4 bottle, dosing 1-12mg/day. Also working my way through 120 PN tabs of 500mcg MK7 (slowly because worried about effects on insulin). Before that I finished 90 caps of 15mg MK4 from Orthica. Before that I finished 2x180 caps of Carlsens 5mg MK4. Before that 500-800 caps of 100mcg MK7 from various brands.

No hair changes. Any mandible or muscle gains are more likely from eating 3000-4000 daily calories (from foods like beef, potatoes, goat milk, and orange juice) and exercising 1-4 x/week. I noticed more boners from Carlsens MK4 caps in the beginning.

At this point, Thorne MK4 gives me annoying headaches like clockwork hours after adding drops to a meal. I deal with the headache by taking aspirin, gamma tocopherol, or serrapeptase. No headaches if I smear the drops on my wrist or mid-arm veins, but of course I'm absorbing less. Don't think I'll buy Thorne MK4 again any time soon. Perhaps I should lay off the K2 for a bit.

 

[Frankdee20]

I'm 3/4 through a Thorne MK4 bottle, dosing 1-12mg/day. Also working my way through 120 PN tabs of 500mcg MK7 (slowly because worried about effects on insulin). Before that I finished 90 caps of 15mg MK4 from Orthica. Before that I finished 2x180 caps of Carlsens 5mg MK4. Before that 500-800 caps of 100mcg MK7 from various brands.

No hair changes. Any mandible or muscle gains are more likely from eating 3000-4000 daily calories (from foods like beef, potatoes, goat milk, and orange juice) and exercising 1-4 x/week. I noticed more boners from Carlsens MK4 caps in the beginning.

At this point, Thorne MK4 gives me annoying headaches like clockwork hours after adding drops to a meal. I deal with the headache by taking aspirin, gamma tocopherol, or serrapeptase. No headaches if I smear the drops on my wrist or mid-arm veins, but of course I'm absorbing less. Don't think I'll buy Thorne MK4 again any time soon. Perhaps I should lay off the K2 for a bit.

Headaches can be from too much K lowering Cortisol or something, that is way too much.

 

[Homo Consumericus]

Headaches can be from too much K lowering Cortisol or something, that is way too much.

This occurred over the last 7-8 years.

 

[Frankdee20]

This occurred over the last 7-8 years.

You have been using K that extensively and that much ?

 

[Homo Consumericus]

You have been using K that extensively and that much ?

Yes, I used to take articles like this-- https://www.ncbi.nlm.nih.gov/pubmed/15514282-- and other epidemiological research much more seriously than I do now. My bias also favoured research coming out of my country (and still does) because we generally have superior internal controls.

 

[GreekDemiGod]

I took 15-45 mg mk4 and increased my test but lowered my estro too low. Speed up hairline recession. I think my jaw was already wide, a week wasn’t enough to see change

How did you recognize the symptoms of too low estrogen?
By what mechanism did your recession speed up?