Serotonin may cause schizophrenia, Parkinson, and Alzheimer diseases


Mar 18, 2013
USA / Europe
One by one, medical myths (slowly) go the way of the Dodo. Two of the most pervasive such myths are that psychotic conditions like schizophrenia are caused by excess dopamine, and Parkinson Disease (PD) is caused by a deficiency of dopamine. Unbeknownst even to most doctors, studies exist demonstrating that hallucinations (indistinguishable from those in people with psychotic conditions like schizophrenia) exist in people with PD. In fact, more than 75% of people with PD experience such hallucinations at some point in their life, which basically makes them a core symptoms of PD. Even more interestingly, the Wiki page below states that the psychosis seen in people with PD may herald the onset of dementia. Hmmm, I wonder what is the most common type of dementia in the elderly (in whom PD is most likely to appear)...Yes, Alzheimer Disease (AD), of course!

Parkinson's disease - Wikipedia

"...Hallucinations or delusions occur in approximately 50% of people with PD over the course of the illness, and may herald the emergence of dementia. These range from minor hallucinations – "sense of passage" (something quickly passing beside the person) or "sense of presence" (the perception of something/someone standing just to the side or behind the person) – to full blown vivid, formed visual hallucinations and paranoid ideation. It is now believed that psychosis is an integral part of the disease."

This is yet another "paradox", recognized by isolated medical studies as early as the 1950s. However, it is very rarely discussed in medical settings simply because it is too "controversial". Why do I put "paradox" and "controversial" in quotes? I do that because, as I mentioned in several prior posts, in the medical world those words are euphemisms for incompetence of sometimes outright fraud. It takes no medical degree to recognize that if hallucinations are caused by excess dopamine then those should rarely (if ever) be found in people with dopamine deficiency conditions such as PD. How does medicine get around this *cough* fraud *cough* I mean "paradox"? By calling such issues Parkinson Disease Psychosis (PDP). If you look up the hallucination symptoms of PDP (see Wiki page above for quick reference) you will immediately see that they are identical to the ones of schizophrenia. No explanation is, of course, given as what differentiates PDP from regular schizophrenia and the charade goes on uninterrupted dragging along the unwitting public.

In several of my previous posts I discussed the extensive evidence that both schizophrenia and PD are both caused by serotonin. Aside from the direct imaging studies on brains of people with either condition, as well as rodent studies, there are also recent studies that stumbled upon the "surprising" evidence that anti-dopamine drugs commonly used for treating schizophrenia such as haloperidol are actually potent serotonin antagonists as well. In a sense, drugs like haloperidol work similarly to the ancient drug reserpine that has been used by native cultures for millennia to sedate and/or treat both psychotic and tremor-related conditions like PD. Reserpine powerfully depletes both dopamine and serotonin, but has a strong preference for the latter. However, that evidence is considered indirect and simply corroborating to the hypothesis that serotonin is the cause of both conditions. The new clinical trial below may add the first piece of direct evidence by demonstrating that serotonin is a causative factor in both psychosis and PD. The trial is based on pre-clinical results (with a limited number of patients) demonstrating that the administration of a selective serotonin (5-HT3) antagonist (ondansetron) is capable of stopping PDP in people with PD. This directly implicates serotonin as a causative factor in both schizophrenia and PDP (and possibly AD as well), because ondansetron is a highly selective 5-HT3 antagonist and does not have any other known effects on monoamines or other mechanisms considered relevant for those conditions. If the trial also demonstrates improvement in other core symptoms of PD then I think serotonin's fate is sealed. While the full-scale trial won't start until 2022 the researchers are pretty confident in their preliminary results, which will hopefully lead to more doctors thinking twice before prescribing SSRI drugs to patients with schizophrenia or PD. More importantly, this direct evidence should prompt re-evaluation by the medical profession about just how "beneficial" serotonin really is and whether there is EVER a rationale for increasing its levels in people. And if there still any doubt that high serotonin, instead of high dopamine, is the culprit - see the quote below describing that a core impetus for conducting the trial has been the drastic increase in hallucinations in people with PDP during the lockdown/pandemic. Even a mainstream doctor will admit it is common knowledge that acute (or chronic) stress, such as social isolation and/or constant fear from an unknown enemy (e.g. virus), elevates serotonin and lowers dopamine. However, if the bigger trial is successful I doubt the popular press will present the news as a collapse of the serotonin house of cards. Even now, in the popular press articles they do not even say serotonin may be pathological. One of the articles does not mention serotonin even once, while the other one only mentions it in regards to ondansetron and even then the information is presented with ambiguity. Instead of saying that ondansetron is a potent and selective serotonin antagonist, which would immediately make it clear that serotonin is the suspected pathological agent in these diseases, they deviously say that ondansetron "binds to serotonin receptors to try to stop the hallucinations". This is criminally malicious level of misreporting because it removes the core message that ondansetron stops the hallucinations not just by binding to the serotonin receptors but by antagonizing / blocking them. What a travesty!

Trial of Ondansetron as a Parkinson's HAllucinations Treatment - Full Text View -
Anti-Nausea Drug Used for Chemotherapy Could Treat Parkinson’s Hallucinations
Cancer anti-sickness drug offers hope for hallucinations in Parkinson’s

"...A world-first double-blind clinical trial led by UCL researchers will investigate if a powerful drug used to treat nausea in chemotherapy patients could alleviate hallucinations in people with Parkinson’s. Parkinson’s UK is partnering with UCL and investing £1 million in a pioneering phase II clinical trial to explore if the drug ondansetron is safe and effective against hallucinations. There are currently 145,000 people living with Parkinson’s in the UK and 75% of them will experience visual hallucinations at some point. The trial comes at a crucial time as a survey carried out by the charity found that one in 10 people with Parkinson’s reported an increase in hallucinations during lockdown, which led to an increase in calls to their helpline."


May 31, 2020
United Kingdom
The more I read about serotonin, the more I am convinced that these conditions are all part of the autistic spectrum, with serotonin being the primary culprit.

Schizophrenia; Schizoid; Bipolar; Borderline Personality Disorder; Depression; Anxiety, the list goes on.


Thread starter
Mar 18, 2013
USA / Europe
The more I read about serotonin, the more I am convinced that these conditions are all part of the autistic spectrum, with serotonin being the primary culprit.

Schizophrenia; Schizoid; Bipolar; Borderline Personality Disorder; Depression; Anxiety, the list goes on.

Yep, and it is no wonder there is an epidemic of all these conditions considering SSRI usage is at an all-time high and continues to rise.
Similar threads
Thread starter Title Forum Replies Date
haidut Serotonin May Be A Cause Of Hemorrhoids And Tinnitus Scientific Studies 2
haidut Serotonin Excess, Not Dopamine Deficiency, May Be The Cause Of Parkinson Scientific Studies 25
haidut Marijuana May Cause Psychosis/schizophrenia By Increasing Serotonin Signalling Scientific Studies 56
haidut Gut Dysbiosis May Cause Autism Through Cortisol And Serotonin Scientific Studies 13
haidut Higher Serotonin Availability May Be The Cause Of Cognitive Impairment / Dementia Scientific Studies 7
haidut Serotonin May Be The Cause Of Fibrosis In Scleroderma (systemic Sclerosis) Scientific Studies 3
charlie "Serotonin deficiency may not cause depression after all" Miscellaneous Health Discussions 4
haidut Serotonin may be the "aggression hormone" in most living organisms Scientific Studies 13
haidut Blocking Serotonin May Treat Allergies And Inflammatory Diseases Scientific Studies 6
GutFeeling Benzodiazepines May Be Strong Serotonin Antagonists. Are They Really That Dangerous? Scientific Studies 59
haidut Chronic Fatigue Syndrome (ME/CFS) May Be Caused By Increased Serotonin Sensitivity Scientific Studies 92
haidut Cocaine "addiction" May Be Driven By Serotonin Scientific Studies 2
DaveFoster Anti-Serotonin Drugs May Treat Fibromyalgia Scientific Studies 26
haidut Delirium In ICU Patients May Be Just Serotonin Syndrome Scientific Studies 5
haidut An Anti-serotonin, Pro-dopamine Drugs May Treat Systemic Sclerosis Scientific Studies 44
haidut DHT Lowers Serotonin Synthesis, May Treat (testicular) Cancer Scientific Studies 12
haidut Itching May Be Driven By Serotonin Scientific Studies 24
haidut Serotonin Causes Autism; Blocking It May Treat Autism Scientific Studies 35
haidut Theanine May Be Better Than PCPA For Reducing Serotonin Scientific Studies 23
haidut Caffeine May Reduce Gut Serotonin Secretion Scientific Studies 8
F Meals Rich In Carbohydrates, But Poor In Protein May Increase Serotonin In The Brain Scientific Studies 13
Hgreen56 Anti-Peat Excess nicotinamide increases plasma serotonin and histamine levels Debate - Anti-Peat 2
L Need serotonin antagonist herbs Supplements, Pharmaceutical Drugs 1
Mauritio Vitamin B1 / Thiamine deficiency increases serotonin in the brain Scientific Studies 24
Michael Mohn Does serotonin in fruit raise serotonin blood levels? Cortisol, Serotonin, Histamine 5
haidut Serotonin (5-HT) is a key driver of asthma Scientific Studies 0
A Study says low serotonin causes mice and rabbits to become gay Scientific Studies 3
Mauritio B. Coagulans decreases endotoxin , liver fibrosis and serotonin Digestion 57
Mauritio Sterile gut leads to lower anxiety, serotonin , and TPH-levels + some bacteria don't increase serotonin Articles & Scientific Studies 4
P Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation (P4 lowers SERT) Progesterone 3
youngsinatra How To Improve Sexual Indurance (With Low Serotonin) Ask For Help or Advice 78
A Octreotide Inhibits GH, Serotonin, Prolactin, TSH, Insulin Supplements, Pharmaceutical Drugs 0
Q Is Vitamin D induced serotonin syndrome possible? Please hear me out... Ask For Help or Advice 60
Mito Serotonin Pathway in Cancer Cancer 1
deliciousfruit I Think High Serotonin Is Holding Me Back Ask For Help or Advice 10
N The "safest" drug to increase serotonin Mental Issues 19
Mito Serotonin receptor 4 in the hippocampus modulates mood and anxiety Articles & Scientific Studies 0
Hans Anti-serotonin stack for more energy and well-being Articles & Scientific Studies 17
Mauritio 10-methoxy-harmalan ,an anti-serotonin chemical? IdeaLabs 34
Lokzo Vitamin B6 Increases Serotonin, Regardless of Serotonin Levels - PUBMED Supplements, Pharmaceutical Drugs 2
GelatinGoblin Low-Moderate sugar meal with no Protein, Serotonin inducing? Ask For Help or Advice 5
Mito Serotonin is elevated in COVID- 19-associated diarrhoea Miscellaneous Health Discussions 39
Atma Ray Peat Interview #30: LSD, Serotonin, and Hallucinations | PUFA and Lipofuscin | Strategy of Tension | William Blake Interviews 4
haidut Serotonin promotes (futile) patience and (false) faith in future rewards Scientific Studies 19
haidut Serotonin (and SSRI drugs) can cause anxiety and PTSD Scientific Studies 0
deliciousfruit cyproheptadine increasing serotonin? Cyproheptadine 23
GorillaHead Is the key to procrastination patience? And is serotonin the key patience? Mental Issues 13
Lokzo This Is How The Carnivore Diet Lowers Serotonin... Diet, Recipes 14
Mauritio Serotonin Depletion Amplifies Distinct Human Social Emotions As A Function Of Individual Differences Scientific Studies 4
Lokzo Do You Have Too Much Serotonin? Miscellaneous Health Discussions 0

Similar threads