Parkinson Disease (PD) May Begin In The Gut


Mar 18, 2013
USA / Europe
The article below is one of at least 20 I have seen in just 2020 alone that are starting to draw attention to the metabolic/inflammatory origins of yet another neurological disease of "mysterious" origin - namely, Parkinson Disease (PD). What makes this article both interesting and infuriating is that apparently the connection between gut pathology, high endotoxin, GI inflammation and PD has been known for more than 200 years! Despite the obvious signs of serotonin overload such as constipation, "shaking palsy", brain fog, indigestion, etc. mainstream medicine has been obliviously pursuing all kinds of other exotic and frankly absurd causes mostly involving around genetics. Maybe it is time to start taking endotoxin (LPS) seriously and stop calling PD a dopamine-deficiency disease. While dopamine levels are arguably lower in such patients, all of the symptoms of PD and especially the unmistakable trembling (that was identified and named as "shaking palsy" more than 200 years ago) are actually CLASSIC signs of serotonin excess.

Serotonin Excess, Not Dopamine Deficiency, May Be The Cause Of Parkinson

Considering the inseparable connection between endotoxin (LPS) and serotonin (90%+ of which is produced in the gut under the influence of endotoxin), it becomes abundantly clear that diet quality and digestive health are squarely at the center of this disease and as such, something as simple as administering a serotonin antagonist or antibiotics may very well cure it.

Does Parkinson’s Begin in the Gut?
"...The earliest evidence that the gut might be involved in Parkinson’s emerged more than 200 years ago. In 1817, the English surgeon James Parkinson reported that some patients with a condition he termed “shaking palsy” experienced constipation. In one of the six cases he described, treating the gastrointestinal complaints appeared to alleviate the movement-related problems associated with the disease. Since then, physicians have noted that constipation is one of the most common symptoms of Parkinson’s, appearing in around half the individuals diagnosed with the condition and often preceding the onset of movement-related impairments. Still, for many decades, the research into the disease has focused on the brain. Scientists initially concentrated on the loss of neurons producing dopamine, a molecule involved in many functions including movement. More recently, they have also focused on the aggregation of alpha synuclein, a protein that twists into an aberrant shape in Parkinson’s patients. A shift came in 2003, when Heiko Braak, a neuroanatomist at the University of Ulm in Germany, and his colleagues proposed that Parkinson’s may actually originate in the gut rather than the brain."

"...Microbes themselves are another potential trigger for promoting the build-up of intestinal alpha-synuclein. Researchers have found that, in mice, bacterial proteins could trigger the aggregation of the alpha-synuclein in the gut and the brain. Some proteins made by bacteria may form small, tough fibers, whose shape could cause nearby proteins to misfold and aggregate in a manner akin to the prions responsible for mad cow disease, explains Robert Friedland, a neurologist at the University of Louisville who coauthored that study."

"...The microbiome, the totality of microorganisms in the human body, has spurred intense interest among Parkinson’s researchers. A number of reports have noted that individuals with the disease harbor a unique composition of gut microbes, and scientists have also found that transplanting fecal microbes from patients into rodents predisposed to develop Parkinson’s can worsen motor symptoms of the disease and increase alpha-synuclein aggregation in the brain."

"...This study further validates the theory that gut inflammation could drive Parkinson’s pathogenesis, says Madelyn Houser, a graduate student in neuroscientist Malú Tansey’s lab at Emory
Similar threads
Thread starter Title Forum Replies Date
haidut Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD) Scientific Studies 1
haidut Simply Inhaling Endotoxin (LPS) May Cause Parkinson Disease (PD) Scientific Studies 2
haidut Niacinamide May Be A Viable Treatment For Parkinson Disease (PD) Scientific Studies 8
haidut Stearic Acid Increases Mitochondrial Function, May Treat Parkinson Disease (PD) Scientific Studies 36
Drareg Increased G6pdh Expression May Protect In Parkinson's Disease Scientific Studies 0
haidut Taurine-like Compounds May Treat Parkinson Disease Scientific Studies 1
haidut Parkinson Disease May Start In The Gut Health 11
charlie An Open-Label Pilot Study With High-Dose Thiamine in Parkinson's Disease Scientific Studies 5
haidut Red Light Therapy For Parkinson Disease (PD) Begins Human Trials Scientific Studies 0
E New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson's Disease Scientific Studies 2
Blossom Antibiotics And Increased Risk For Parkinson's Disease? Articles & Scientific Studies 9
haidut Drop In Androgen Levels Causes Parkinson Disease (PD), DHT Reverses It Scientific Studies 39
Fractality The Appendix Is Implicated In Parkinson’s Disease Scientific Studies 15
D X-rays Reveal The Important Role Of Copper In Parkinson’s Disease Scientific Studies 6
Soren Methylene Blue And Light For Lymes Disease/Parkinson's? Mental Issues 0
haidut Tremor In Parkinson Disease (PD) Is Due To High Serotonin Scientific Studies 20
haidut Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease Scientific Studies 12
P Reduced Plasma Taurine Level In Parkinson's Disease: Association With Motor Severity And Levodopa Tr Articles & Scientific Studies 1
Soren Parkinson's Disease Cancer, Degenerative Diseases 59
K Supplements For Parkinson Disease Cancer, Degenerative Diseases 26
Mr Rossi Thiamine (b1) Reverses Parkinson Disease In Humans - Before/after Videos Scientific Studies 8
haidut Thiamine (B1) Reverses Parkinson Disease In Humans Scientific Studies 61
haidut Inhibiting Hypoxia Biomarker (HIF-1) Reverses Parkinson Disease Scientific Studies 38
sweetly Near-infrared Light Is Neuroprotective In A Monkey Model Of Parkinson's Disease. (2015) Scientific Studies 0
sweetly Caffeine And Progression Of Parkinson Disease: A Deleterious Interaction With Creatine Cancer, Degenerative Diseases 47
Lilac Parkinson's disease: any Peat recommendations? Ask For Help or Advice 14
haidut Parkinson Disease Is An Energetic/metabolic Disorder Mind, Sleep, Stress 17
L Freezing Gait & Slow Movement (Possible Parkinson’s) My Dad is 55 Ask For Help or Advice 16
haidut Serotonin may cause schizophrenia, Parkinson, and Alzheimer diseases Scientific Studies 2
S Lisuride Healed My Parkinson Testimonials 34
Mito New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson’s Articles & Scientific Studies 0
methylenewhite Parkinson’s Begins In The Gut. One More Study Scientific Studies 4
Kingpinguin Dietary Vitamin E But Not Supplemental Significantly Decreased Risk Of Parkinson Scientific Studies 11
mrchibbs New Study: Parkinson Could Be Linked To Intestinal Infections Scientific Studies 6
haidut Serotonin Excess, Not Dopamine Deficiency, May Be The Cause Of Parkinson Scientific Studies 25
Seleniodine Serotonin Link To Parkinson's Scientific Studies 0
D Lower Ceruloplasmin Found In Parkinson’s Scientific Studies 44
L Exemestane (AI) Protects Against Parkinson Scientific Studies 16
H Purine Ingestion With Molybdenum Deficiency - Parkinson’s Scientific Studies 0
haidut Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's Scientific Studies 20
burtlancast Parkinson Caused By Nuclear Radioactivity? Miscellaneous Health Discussions 3
brocktoon Chronic Lack Of Energy W/Parkinson's Ask For Help or Advice 18
haidut White-collar Jobs Linked To ALS And Parkinson Scientific Studies 15
SQu KMUD 170317 Endocrinology, Parkinson's 1 Audio Interview Transcripts 7
Soren More Evidence Parkinson's Starts In The Gut Digestion, Gut Flora 1
Dan Wich KMUD: 3-17-17 Endocrinology (Part 1): Parkinson's KMUD Radio-The Herb Doctors 19
yerrag Thoughts And Advice On My Cat Condition Progressing From Hyperesthesia Towards Parkinson's Animals 20
haidut RoundUp (glyphosate) Linked To Alzheimers, Parkinson And ALS Scientific Studies 4
I Niacinamide Parkinson's Connection? B3/Niacinamide 13
haidut Aspirin Effective For Alzheimer, Parkinson And Huntington Aspirin 4

Similar threads