psychosis

A great study highlighting once again the importance of calcium, vitamin D and especially the pro-inflammatory parathyroid hormone (PTH) for mental health. While there are many studies (both observational and intervention ones) examining the role of vitamin D in mental health, this is one of the...

Both human and animal studies. The human study was with pyridoxamine - a vitamin B6 isomer declared by FDA to be a "prescription drug" and as such banned for OTC sale in USA while still being widely available in most other countries. That FDA ruling is pointless due to the fact that pyridoxamine...

One by one, medical myths (slowly) go the way of the Dodo. Two of the most pervasive such myths are that psychotic conditions like schizophrenia are caused by excess dopamine, and Parkinson Disease (PD) is caused by a deficiency of dopamine. Unbeknownst even to most doctors, studies exist...

The evidence for the role of chronic stress in virtually every health condition doctors have a name for just keeps on accumulating. Unfortunately, even in this latest study the scientists keep insisting that there is some mysterious and unquantifiable difference between chronic stress...

Fraud, fraud and nothing but fraud! After more then half a century of claiming that serotonin cures depression, now mainstream medicine is quietly trying to retreat from this fiasco by introducing more and more potent (and selective) serotonin antagonists as treatment of depression and silently...

The study looked at correlations between ambient temperature and criminal activity and found that higher temperatures correlate with reduced SERT density and as such elevated serotonin. The SERT protein is the one that deactivates serotonin and it is a sodium dependent protein. Serotonin...

Yet another nail in the coffin of the "happiness hormone", which may end up being one of the biggest scientific frauds of the 20th century, rivaling the one about estrogen being the "female" hormone. It has been known for a long time that both lithium and methylene blue, both of which are...

I know the topic of weed is controversial but by now the link between heavy and chronic marijuana use and the risk of psychotic conditions like schizophrenia has been well established. Peat mentioned a few times briefly that cannabis has anti-androgenic effects and should not be used chronically...

I posted a number of studies on Ceylon cinnamon and its metabolite sodium benzoate, showing their benefit in Parkinson disease, depression and anxiety. While all of those studies were on animal models, the toxicity of ammonia in the brain is undisputed and its role in all of these disease has...

Peat has mentioned GABA quite a few times in his articles and its role as the chief inhibitory signal in the body, protecting both brain cells and peripheral tissues/organs from excitotoxicity caused by PUFA, glutamate, estrogen, stress, etc. But the role of GABA is especially prominent in the...

The study itself has a misleading title because there are quite a few situations that can result in lower brain pH (and thus high acidity). High levels of CO2 can also cause low brain pH levels, but as I posted in a few other studies drugs that raise CO2 levels can actually treat mental disease...

I posted a number of threads on the dangerous "side" effects of the SSRI class of drugs. The reason I put "side" in quotes is that considering their pro-serotonergic profile these are not really side effects but expected results along the main known mechanism of action of those drugs. Serotonin...

A human study, and as such very relevant. The dose (4g daily for 12 weeks) was a bit on the high end but that was probably because the scientists designing the trial were unaware of the studies showing benefits of taurine plateau after 2g daily. In any event, good news for those with mood/mental...

The study was on bipolar disorder psychosis, which is different from the psychosis in conditions like schizophrenia. The psychosis of bipolar disorder is believed to be caused by cortisol, and since methylene blue helped then it suggests methylene blue can lower excessive cortisol. This is not...

I have suspected this for a long time, but the official version to this day is that schizophrenia is primarily a gene-driven disease linked to a "misbehaving" cluster of about 300 genes. The fact that most of these genes are related to serotonin metabolism is considered, of course, irrelevant to...

After more than 5 decades of claiming that psychosis conditions like schizophrenia are caused by excessive dopaminergic activity and depression is a deficiency of serotonin, big pharma is doing 180 degrees reversal. A new drug was just approved for treating bipolar disorder and schizophrenia in...

I have suspected that DMSO has central effects given how powerfully sedating it can be for some people. This older study compares the effects of DMSO to the ancient tranquilizer reserpine, which Peat has written about before. This would make DMSO an effective serotonin lowering agent, an...