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So pretty much it helps to regulate hormone levels...I don’t read that as a bad thingAnti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase - PubMed
Previously, we have demonstrated that policosanol from Chinese wax suppressed testosterone(T)-induced alopecia in mice. However, the underlying mechanism remained to be determined. Herein, we investigated the mechanism of policosanol against androgenetic alopecia (AGA). AGA was induced in...pubmed.ncbi.nlm.nih.gov
not sure if this has been posted here but it seems interesting
What does policosanol do to unsaturated fats and how much do u use daily@haidut is policosanol a PPAR alpha agonist since it is a PPAR gamma antagonist? Been wanting to experiment with a SDC1 hibitor to increase the ratio if sfa to pufa in fat tissue. I dont want to use berberine for PPAR alpha activation as far as I know its anti androgenic whereas policosanol is not. Also, I have a theory the tocopherols and policosanol saturate body fat through a similar enzymes to SDC1. Since both compounds on their own are quite potent antagonizers to unsaturated fats.
ProbablyWould it be enough for me to eat 2 grams of beeswax every day for Policosanol?
Yes it is. That is it's main feature as a nanospray formulation. There is a lot online about it. I am personally acquainted with the inventor and have had many conversations with him about the product.@haidut do you rate this as a source of Policosanol? NANO SOMA | Home
Mate I know Peat has also said 20mg is a good dose,Human studies show that 20mg daily is probably optimal as higher doses are not more beneficial for things like lowering cholesterol/inflammation, increasing endurance or lowering risk of CVD. That dose is more than enough to reach the picogram/ml concentrations the link above claims increased Klotho expression 4-10 times.
Not if is allowing your body to use cholesterol the way it's meant to. Ie. Converted to steroids. Statins largely inhibit the formation of cholesterol. I don't think this is what this does@haidut on another thread someone mentioned policosanol lowering tsh. Would that mean its risky to use in people who have the low tsh form of hypothyroidism.
Also, are there risks to the cholesterol lowering effects of policisanol. If it lowers cholesterol wouldnt that mean it would reduce the androgens, progesterone, dhea, etc since the base material of cholesterol is being lowered. I noticed policosanol has a drying effect on scalp hair and it also seems to help the skin clear up. I was thinking that is related to the cholesterol lowering effect as well. Is it detrimental to take anything that lowers cholesterol including policosanol. For example the statin drugs, because of their cholesterol lowering effects reduce testosterone levels, reduce vitamin D and K2 production, among other effects. Wouldnt policosanol cause the same issues as those other cholesterol lowering drugs.
Not if is allowing your body to use cholesterol the way it's meant to. Ie. Converted to steroids. Statins largely inhibit the formation of cholesterol. I don't think this is what this does
I don't know how it works, but i don't think it blocks enzymes like statins. Probably helps the liver to do it's job better, which converts cho. I've only started reading about polycosanol this week. Sounds like it's similar in substance to stearic acid.Does policosanol promote conversion of cholesterol to the steroids?
Someone on here claimed it is a 5 alpha reductase inhibitor. Also its found naturally in things like wheat germ, the waxy part of sugarcane, beeswax.I don't know how it works, but i don't think it blocks enzymes like statins. Probably helps the liver to do it's job better, which converts cho. I've only started reading about polycosanol this week. Sounds like it's similar in substance to stearic acid.
I don't think medical science knows much about this, or many, substances. Much less the body. I just read a review of it and it says one of the mechanisms they think it works is by inhibiting an enzyme (mevalonate) for cholesterol biI synthesis. The whole review sounded like a guess and based strictly around the high cholesterol bad/pro statin premise.Someone on here claimed it is a 5 alpha reductase inhibitor. Also its found naturally in things like wheat germ, the waxy part of sugarcane, beeswax.
I don't think medical science knows much about this, or many, substances. Much less the body. I just read a review of it and it says one of the mechanisms they think it works is by inhibiting an enzyme (mevalonate) for cholesterol biI synthesis. The whole review sounded like a guess and based strictly around the high cholesterol bad/pro statin premise.
Ray was fairly positive on policosanols, but he was also always suspicious of substances that inhibited enzymes. Take it for what you will. I haven't seen anything to do with inhibiting 5AR. Might be speculation from the hair loss forums spreading.
The best way to know is to experiment and do labs. It seems like you've tried it and don't like it so you can probably move on. I just started mine at 25mg/day yesterday.
Thanks. It sounds like it's reliant upon the particular individuals health and liver status. I'm looking forward to seeing how my body responds to 25mg (that's what's in the NutriCost supplement I purchased). Probably would have been wiser to start with 10mg, but this is what it isI think too much can disturb assimilation and digestion of fats.
It can affect the liver if fat isn’t digested in the normal ways.
Those are some of his comments on policosanol
I asked him
Is 20mg policosanol taken daily, safe if taken daily for many years
He said i think its safe at the right dose.
So im not sure if he was agreeing that 20mg is fine or not.
He said chewing sugar cane is the best way to get policosanols.
He said he doesnt think policosanol would block absorption of fat soluble supplements taken alongside it.
But i wonder if it interferes with digestion and assimilation of fats doesnt it mean it can reduce fat soluble vitamin absorption from food sources… and also affect cholesterol digestion
Thanks. It sounds like it's reliant upon the particular individuals health and liver status. I'm looking forward to seeing how my body responds to 25mg (that's what's in the NutriCost supplement I purchased). Probably would have been wiser to start with 10mg, but this is what it is