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sfa

  1. haidut

    Lipolysis preferentially releases PUFA from adipose tissue

    ...compared to SFA and/or MUFA. This topic is considered highly controversial in Peat-land, mostly because of the dearth of studies dealing with it. I must have received hundreds of emails at this point criticizing Peat's stance on this issue and claiming that there is no evidence for...
  2. haidut

    Stearic acid (SA) is an estrogen receptor antagonist

    Over the last year or so I stumbled upon a few studies claiming both SA (C18:0) and its methyl ester are capable of binding the estrogen receptors (ER) and modulate their transcription effects. However, those studies did not evaluate if SA acted as an agonist or antagonist on those receptors...
  3. miquelangeles

    Botanical fixed oils clustered according to their fatty acid composition and saturation SFA:MUFA:PUFA ratios

    From: The Enigma of Bioactivity and Toxicity of Botanical Oils for Skin Care @Mauritio bear fat is also mentioned
  4. aliml

    The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk

    SFAs play the leading role in 1 of the greatest controversies in nutrition science. Relative to PUFAs, SFAs generally increase circulating concentrations of LDL cholesterol, a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, the purpose of regulatory mechanisms that...
  5. haidut

    Protein and saturated fats beneficial, PUFA detrimental for thyroid

    A good new study, which again confirms that saturated fat is anything but detrimental to our health. Most of the studies until now demonstrating improved thyroid function from saturated fat used coconut oil, and that has led to attacks from mainstream medicine that this pro-thyroid and healthy...
  6. Mauritio

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity

    Why PUFA is bad: how high membrane polyunsaturation decreases longevity: This is probably one of the most interesting papers I've read in a long time . It goes into depth about the danger of PUFA and conncects the dots between PUFA ,membranes ,rate of living theory, life expectancy, and...
  7. haidut

    PUFA is catabolic, SFA is anti-catabolic (anabolic)

    During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT...
  8. haidut

    Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho

    This post is a good complement to the recent ones I did on androgens, estrogens and their opposing effects on the expression of the anti-aging gene Klotho. While I was doing research on that gene, I had a "random" thought pop up in my mind. It is well-known that some Caribbean countries have a...
  9. haidut

    PUFA Exacerbate, Saturated Fats (SFA) / Albumin / Calcium Ameliorate COVID-19

    A few months ago I posted about a study discussing the role of lipid peroxidation in the COVID-19 pathology. While that study did not make any statements about effects of diet on the disease course/outcome, it did suggest lipid peroxidation blockers such as vitamin E would be therapeutic. Now...
  10. haidut

    SFA / MUFA Are Preferentially Oxidized, While PUFA Are Stored/accumulated

    Just a quick post in response to some of the hate mail I keep getting on a daily basis in regards to the body's discriminatory treatment of various fat types. According to various proponents of keto diets, fasting, etc the organism has no preference for one type of fat or another in terms of...
  11. haidut

    Cholesterol And SFA Are Anabolic; PUFA/MUFA Akin To Chemical Castration

    A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much...
  12. haidut

    Supplementation With (long Chain) Saturated Fats Protects Liver From Alcohol

    As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...
  13. haidut

    Saturated Fats (SFA) Increase Glucose Oxidation While PUFA Decrease It

    This is great human study that addresses two key questions people have often asked Peat in regards to SFA vs. PUFA. As Peat has mentioned several times, during stress (exercise in this case) PUFA is preferentially oxidized while SFA is stored. The preferential oxidization of PUFA during stress...
  14. haidut

    CNN News - Running Lowers Testosterone In Males

    When news like this features on CNN, it is becoming obvious that something it not right with the official recommendations for regular (endurance) exercise as the best way to ward off CVD, cancer, brain diseases, osteoporosis, etc. The CNN piece also states that vitamin D supplements, weight...
  15. haidut

    Saturated Fat (palmitate) Does NOT Activate TLR4

    We must have had hundreds of discussions on this topic on the forum. Some forum users strongly believe that saturated fat (SFA) increases inflammation by binding to and activating the endotoxin (LPS) receptor TLR4. Among all SFA, palmitate is the one most commonly blamed and has been...
  16. haidut

    Western Diet Or SFA Strikingly Protective Against Colon Cancer And Mortality

    No, this is not an April's fool joke. Kind of surprising that this study did not make front page news on MSM, but it may be better this way as the study will probably quickly get retracted if it becomes more popular. Several important findings in this study. The first one is probably the...
  17. haidut

    Topical Stearic Acid Is Metabolized Into Longer Chain SFA

    This seems like a very interesting study, but is in French and not available from PubMed. So, I am hoping @burtlancast would be able to obtain it and maybe translate the relevant fractions. The study shows that dietary stearic acid is both incorporated into cell lipids and metabolized further...
  18. haidut

    PUFA Increases Alcohol Damage By Increasing Cell Fluidity; SFA Are Protective

    Peat has written a number of times on the synergies of PUFA with ethanol and endotoxin on causing liver and systemic damage. In one of his articles he opined that in the absense of PUFA/iron ethanol would likely not cause much harm. He also wrote about the protective effects of saturated fats...
  19. haidut

    PUFA Is Directly Catabolic (without Cortisol/estrogen), SFA Is Anabolic

    I posted a few studies about PUFA potentiating the stress response and cortisol synthesis, even without the typical elevations of ACTH present in organic stress reactions. Saturated fats block that pro-stress effects of PUFA...
  20. haidut

    Serotonin / PUFA Drive Migraine

    The role of serotonin in migraines is becoming more recognized every day. Unfortunately, SSRI drugs are still being used to treat migraines, but more recent studies found that serotonin antagonists like cyproheptadine or mianserin are much more effective. The study below found that linoleic...
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