Ok, thanks again. He isn't going to want to hear that but I'm sure he won't have a problem taking pregnenolone. Since you just posted about scrotum application, would that be preferred? Or should he apply the Pansteroone to the painful area?I am afraid all NSAIDs except aspirin are suspect. The study above covers all of them and they all have the same side effects on the heart. Coconut oil, magnesium, and glycine would be the safe anti-inflammatories if he is not willing to try steroids like pregnenolone.