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DHEA can be used for addiction. There's an inverse correlation between DHEA-S and addition as well as relapse. Haidut has posted some studies that stress and cortisol promote addiction. DHEA levels and supplementation has been found to reduce drug cravings and relapse regardless of cortisol levels, which indicates that it's anti-addiction properties are not only through lowering stress.
The research shows that DHEA and DHEA-S reduce addiction through increasing the DHEA:cortisol ratio and lowering the stress response thus improving mental resiliency, activating the NMDA and sigmoid receptor, blocking excess glutamate and GABA-A, as well as increase allopregnanolone and beta-endorphins.
Dehydroepiandrosterone and Addiction - ScienceDirect
"In a research monograph written by Wilkins et al. at the end of the previous millennium (1996), the authors suggested that plasma levels of DHEA sulfate (DHEAS) may be used to discriminate between treatment outcomes in groups of cocaine addicts (Wilkins et al., 2005). They found that those who had high basal levels of DHEAS remained abstinent following treatment for cocaine dependence/detoxification."
"Chronic cocaine self-administration induced elevations in brain DHEA, its sulfate ester, DHEAS, and pregnenolone"
"Drugs blocking central corticotropin-releasing hormone (CRH) receptors or decreasing ACTH and CORT can attenuate self-administration"
"DHEA treatment caused a decrease in both CORT and ACTH levels at similar doses (Maayan et al., 2006, 2005). Such a decrease may explain, at least in part, the attenuation in cocaine-seeking behavior."
"On the other hand, treatment with dehydroepiandrosterone (DHEA), a σ1R receptor agonist, albeit chronically, attenuates cocaine self-administration and relapse to cocaine-seeking behavior in rats"
"DHEAS, which promotes presynaptic glutamate release in the prelimbic cortex via activation of σ1R (Dong et al., 2007), may alleviate drug-seeking behavior."
"DHEA is a positive modulator of the NMDA-R (Dubrovsky, 2005; Mellon & Griffin, 2002a, 2002b; Rupprecht & Holsboer, 1999) and may attenuate cocaine-induced effects by enhancing glutamate activity."
"PREG sulfate acts as an AMPA-R negative modulator (Dubrovsky, 2005). Therefore, one may assume that DHEAS (partially converted from DHEA) acts similarly. This is supported by Kimonides et al. (1998), who found that DHEAS attenuates AMPA and kainate neurotoxicity in hippocampal neurons"
The research shows that DHEA and DHEA-S reduce addiction through increasing the DHEA:cortisol ratio and lowering the stress response thus improving mental resiliency, activating the NMDA and sigmoid receptor, blocking excess glutamate and GABA-A, as well as increase allopregnanolone and beta-endorphins.
Dehydroepiandrosterone and Addiction - ScienceDirect
"In a research monograph written by Wilkins et al. at the end of the previous millennium (1996), the authors suggested that plasma levels of DHEA sulfate (DHEAS) may be used to discriminate between treatment outcomes in groups of cocaine addicts (Wilkins et al., 2005). They found that those who had high basal levels of DHEAS remained abstinent following treatment for cocaine dependence/detoxification."
"Chronic cocaine self-administration induced elevations in brain DHEA, its sulfate ester, DHEAS, and pregnenolone"
"Drugs blocking central corticotropin-releasing hormone (CRH) receptors or decreasing ACTH and CORT can attenuate self-administration"
"DHEA treatment caused a decrease in both CORT and ACTH levels at similar doses (Maayan et al., 2006, 2005). Such a decrease may explain, at least in part, the attenuation in cocaine-seeking behavior."
"On the other hand, treatment with dehydroepiandrosterone (DHEA), a σ1R receptor agonist, albeit chronically, attenuates cocaine self-administration and relapse to cocaine-seeking behavior in rats"
"DHEAS, which promotes presynaptic glutamate release in the prelimbic cortex via activation of σ1R (Dong et al., 2007), may alleviate drug-seeking behavior."
"DHEA is a positive modulator of the NMDA-R (Dubrovsky, 2005; Mellon & Griffin, 2002a, 2002b; Rupprecht & Holsboer, 1999) and may attenuate cocaine-induced effects by enhancing glutamate activity."
"PREG sulfate acts as an AMPA-R negative modulator (Dubrovsky, 2005). Therefore, one may assume that DHEAS (partially converted from DHEA) acts similarly. This is supported by Kimonides et al. (1998), who found that DHEAS attenuates AMPA and kainate neurotoxicity in hippocampal neurons"