Low-dose niacinamide has striking anti-obesity effects

[Mazzle]

I need this! Where can I get it. All the technical / chemical terms are beyond me. Point me to a shopping cart please!

 

[Lizb]

I need this! Where can I get it. All the technical / chemical terms are beyond me. Point me to a shopping cart please!

Konrad nutrition but currently offline - I don't know why or for how long

 

[Mazzle]

Thank you. I found this on Amazon, attached. Is it the same thing?. Niacinamide (vitamin b-3) is a form of niacin, a water soluble b-vitamin

 

[Peater]

Thank you. I found this on Amazon, attached. Is it the same thing?. Niacinamide (vitamin b-3) is a form of niacin, a water soluble b-vitamin

That's what I will take. I've had some for ages and forgot about.

 

[nomoreketones]

That's what I will take. I've had some for ages and forgot about.

Jarrow sells it in 250 mg capsules.

 

[Elie]

2.5 mg per kg for mice
divide by 12 for humans: 0.208 mg per kg for a human?

 

[haidut]

Sorry, I read too quickly. Thought 2.5mg whas the dose the mice were given. Can we agree that NAM supplementation theoretically requires increasing glycine intake?

Why glycine? NAM depletes methyl groups so it might increase need for methionine, but considering how much is in our diet already I doubt it is an issue for most people, especially with NAM doses in the 2.5mg/kg daily range.

 

[haidut]

2.5 mg per kg for mice
divide by 12 for humans: 0.208 mg per kg for a human?

No, it is explained in my post. The 2.5mg/kg is the HED (human equivalent dose), so it is already converted from the mouse dosage.

 

[Elie]

No, it is explained in my post. The 2.5mg/kg is the HED (human equivalent dose), so it is already converted from the mouse dosage.

HED, right.
My apologies.

 

[Mauritio]

Interesting... PPAR alpha controls beta oxidation by upregulating CPT1, the enzyme that controls the rate at which fat enters the mitochondria.

Peroxisome proliferator-activated receptor alpha - Wikipedia

en.wikipedia.org

As you can see in one of the screenshots I posted, fatty acid oxidation is quite increased as well. I think that's normal, same happens with uncoupling and it's not just the fat oxidation that is increased ,carb oxidation as well. Nutrient oxidation in generel you could say.

Otherwise it would have been hard to loose that amount of fat in such a short time.

 

[Nebula]

No, it is explained in my post. The 2.5mg/kg is the HED (human equivalent dose), so it is already converted from the mouse dosage.

For raising NAD levels is it better to consume niacinamide in one or multiple doses throughout the day?

 

[mostlylurking]

For raising NAD levels is it better to consume niacinamide in one or multiple doses throughout the day?

FWIW, for over a year I took about 180mg niacinamide 2Xday with no weight loss. Last November I changed and began taking half that dose (=90mg) 4Xday. I've lost over 25 pounds since that change. I did not change my diet but I have become more active, including adding mild exercises each morning. It now feels good to exercise.

Niacinamide is water soluble so it doesn't last very long in the body; maybe a couple of hours I think.

 

[LeeLemonoil]

I remember years when most on the Forum assumed that niacinamide blocks beta-oxidation. Rationalizing either meagre fat loss on peaty diets / supp regimes with it or hoping when losing weight that niscunamide prevents oxidation of stored pufa

 

[PowertothePeatple]

FWIW, for over a year I took about 180mg niacinamide 2Xday with no weight loss. Last November I changed and began taking half that dose (=90mg) 4Xday. I've lost over 25 pounds since that change. I did not change my diet but I have become more active, including adding mild exercises each morning. It now feels good to exercise.

Niacinamide is water soluble so it doesn't last very long in the body; maybe a couple of hours I think.

How did you consume it? I am assuming you used a powder. Did you mix it into anything? And do you feel the difference in weight loss was from spreading it out over the day i.e. more coverage of time?

 

[BRBsavinWorld]

FWIW, for over a year I took about 180mg niacinamide 2Xday with no weight loss. Last November I changed and began taking half that dose (=90mg) 4Xday. I've lost over 25 pounds since that change. I did not change my diet but I have become more active, including adding mild exercises each morning. It now feels good to exercise.

Niacinamide is water soluble so it doesn't last very long in the body; maybe a couple of hours I think.

niiiice

 

[mostlylurking]

How did you consume it? I am assuming you used a powder. Did you mix it into anything? And do you feel the difference in weight loss was from spreading it out over the day i.e. more coverage of time?

I mix it in orange juice and I also just mix it in water. It doesn't taste bad and dissolves instantly.

 

[mostlylurking]

How did you consume it? I am assuming you used a powder. Did you mix it into anything? And do you feel the difference in weight loss was from spreading it out over the day i.e. more coverage of time?

Yes, I do believe multiple small doses helped and work better that just one or two larger doses.

 

[PowertothePeatple]

Here is an interesting study in humans. The effects appeared to be similar. They increased the dose every 4 weeks, starting at 250 mg up until 1 g.
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

 

[dallascat]

Here is an interesting study in humans. The effects appeared to be similar. They increased the dose every 4 weeks, starting at 250 mg up until 1 g.
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

Niacin == NAM?

 

[PowertothePeatple]

Niacin == NAM?

My understanding is that is an abbreviation for Nicotinamide which is another name for Niacinamide which is a form of Niacin. (But someone correct me if I got that wrong.) I think the problem with Niacin is that it causes unpleasant flushing sensation so they use Niacinamide instead.