Niacinamide May Be A Viable Treatment For Parkinson Disease (PD)

haidut

Member
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to reversal of aging.
This latest study shows that PD is another condition that may be treatable by simply raising NAD levels inside the cell, which stimulates the creation of new mitochondria and thus increases energy production. The study also tested plain old niacinamide (NAM) and that worked too. They chose to go with NR for the bulk of the study since NR raised NAD levels more than niacinamide did, even though the difference was NOT significant (as a recent humans study comparing NR and NAM also confirmed). The concentrations used in the study to reverse PD pathology correspond to about 2g-3g HED of NR (or NAM) daily, which is on par with the 3g daily dose of NAM used in the ongoing human trial for Alzheimer disease.

https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30742-3
https://medicalxpress.com/news/2018-06-vitamin-b3-positive-effect-nerve.html

"...Unsteady hands, stiff muscles and slow movements – all these are typical symptoms of Parkinson's disease. Some 220,000 people in Germany are affected by the disease, which becomes more likely to occur as people get older. It is caused by the loss of nerve cells in the brain and remains incurable. A team of researchers headed by Dr. Dr. Michela Deleidi at the Hertie Institute for Clinical Brain Research and the University of Tübingen is now reporting that nicotinamide riboside – a form of vitamin B3 – may offer a possible treatment. Initial results from the laboratory are promising: "This substance stimulates the faulty energy metabolism in the affected nerve cells and protects them from dying off," Deleidi explains. The researchers have published their study in the latest edition of the journal Cell Reports."

"...The researchers then sought to stimulate the formation of new mitochondria. The coenzyme NAD plays an important role. The researchers 'fed' the cells with nicotinamide riboside, a form of vitamins B3 and a preliminary stage of the coenzyme. This led to a rise in the concentration of NAD in the cells. The result: "The nerve cells' energy budget improved considerably. New mitochondria formed and energy production rose."

"...In order to observe the effect of the vitamin in a living organism, the researchers took the further step of investigating flies with a GBA gene defect. As with Parkinson's patients, the flies' dopamine-rich nerve cells died off, and as they age, the flies have increasing difficulties in walking and climbing. Deleidi and her colleagues divided the flies into two groups. One group received feed enriched with the vitamin, the other did not. "The substance had a positive effect here as well. In the flies which were treated, far fewer nerve cells died off." Furthermore, they retained their mobility longer.

"Our results suggest that the loss of mitochondria does indeed play a significant role in the genesis of Parkinson's disease," Deleidi summarizes. "Administering nicotinamide riboside may be a new starting-point for treatment." Further studies are needed to determine whether the vitamin can be of real help with Parkinson's. The researchers are planning to test the effects of nicotinamide riboside on patients. Other studies have shown that it is well tolerated by healthy test subjects and boosts their energy metabolism as well," Deleidi says."
 

Fractality

Member
Joined
Jan 23, 2016
Messages
772
If one were to replicate the study, would the 3 grams be administered at once or separated into multiple doses over the course of a day? Also, I'm guessing a lot of sugar/carbohydrate would be needed.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
If one were to replicate the study, would the 3 grams be administered at once or separated into multiple doses over the course of a day? Also, I'm guessing a lot of sugar/carbohydrate would be needed.

The in vivo study with zebra fish used it in continuous supply through the day, so I guess the closest approximation would be several separate doses totaling 2g-3g daily.
 

Soren

Member
Joined
Apr 5, 2016
Messages
1,157
Great study. I'm guessing Niacnamide combined with other NAD boosters such as Inosine would work very well together.
 

sugarbabe

Member
Joined
Sep 13, 2012
Messages
3,331
Wow great study! I knew someone with Parkinson's who would only smoke cigarettes as relief of his symptoms. Crazy how people can go for a long time with a disease with no hope of getting better when there are actual treatments that are safe and effective out there.
 

brocktoon

Member
Joined
Apr 10, 2017
Messages
119
It looks like the pharma industry is experiencing a resurgence in the search for metabolic therapies with patented chemicals. There must have been at least 50 different studies in 2017 alone with the NAD precursor nicotinamide riboside (NR) for conditions ranging from cancer, to glaucoma, to reversal of aging.
This latest study shows that PD is another condition that may be treatable by simply raising NAD levels inside the cell, which stimulates the creation of new mitochondria and thus increases energy production. The study also tested plain old niacinamide (NAM) and that worked too.
@haidut I understand your comment about the use of niacinamide in this context. Question: for some with PD, might the concurrent use of a ribose supplement help in terms of purported energy/mitochondrial-boosting effect?

I've also considered supplements like thiamine and TUDCA in this context (i.e., supplements that may help combat PD). Thanks.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
17,440
Location
USA / Europe
Does milk consumption cause Parkinson's @haidut ? This query was never completely adressed in the other thread.

I don't think so. Parkinson's is akin to accelerated brain aging and I don't think milk can cause or even exacerbate that process.
 
Similar threads
Thread starter Title Forum Replies Date
haidut Niacinamide may treat ALS by improving energetic state Scientific Studies 0
haidut Niacinamide may treat depression by improving energetic state Scientific Studies 8
haidut Niacinamide (vitamin B3) May Cure HIV (human Study) Scientific Studies 9
haidut Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss Scientific Studies 5
haidut Dietary Niacinamide (B3) Deficiency May Be A Cause Of Schizophrenia Scientific Studies 7
haidut Niacinamide May Restore Female Fertility In Old Age Scientific Studies 17
haidut Niacinamide May Improve Symptoms Of ALS Scientific Studies 1
haidut Niacinamide May Help Treat/reverse Heart Disease Scientific Studies 1
Koveras Tuberculosis Depletes NAD+ (and Niacinamide May Be Able To Treat It) Scientific Studies 1
haidut Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study Scientific Studies 5
haidut Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help Scientific Studies 0
haidut Niacinamide Lowers BP, May Reverse CVD And Reduce Heart Attack Risk By 25% Scientific Studies 14
haidut Niacinamide May Treat Brain Cancer (glioblastoma) Scientific Studies 8
haidut Niacinamide And Doxycycline May Treat Alzheimer Disease (AD) Scientific Studies 7
haidut Niacinamide May Treat ALS (and Stroke) Scientific Studies 6
haidut High-dose Vitamin C Or Niacinamide May Treat Advanced Colon Cancer Scientific Studies 12
haidut Niacinamide May Prevent Melanoma Scientific Studies 4
haidut Niacinamide May Fully Prevent Miscarriages And/or Birth Defects Scientific Studies 1
haidut Rheumatoid Arthritis Is A Metabolic Disease; Vitamin K And Niacinamide May Treat It Scientific Studies 57
haidut Niacinamide May Treat Hepatitis B Scientific Studies 1
haidut Niacinamide May Be Able To Treat Both HIV And Tuberculosis Scientific Studies 2
C Whats the verdict on Niacin/Niacinamide? Supplements, Pharmaceutical Drugs 26
IROM Alpecin shampoo: Caffeine, Taurine and Niacinamide (are corporations on to Peating?) Hair & Nails 9
youngsinatra High Dose Niacinamide Self-Experiment. Experiments 29
haidut Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide Scientific Studies 2
S Aspirin, niacinamide and eye bags Supplements, Pharmaceutical Drugs 7
J Niacinamide Ask For Help or Advice 15
SOMO Niacinamide + Vit C = Niacin? Ask For Help or Advice 0
Razvan Niacinamide Help Ask For Help or Advice 1
pauljacob Can I Break Open A Niacinamide, Pregnenolone Capsule? Supplements, Pharmaceutical Drugs 4
charlie Vitamin B3 (Niacinamide) Shows Promise For Glaucoma Patients In Clinical Trial Scientific Studies 2
snacks Niacinamide And Dandruff Skin 2
ddjd Niacinamide Great For Sleep. Niacin Terrible. Why? Ask For Help or Advice 10
Hgreen56 Niacinamide Inhibits Fatloss And Niacin Improve It? Supplements, Pharmaceutical Drugs 10
ampersand Ataxia, Iron, Methylene Blue, Niacinamide Supplements, Pharmaceutical Drugs 2
C Aspirin/Niacinamide/Pyrucet Supplements, Pharmaceutical Drugs 7
meatbag Has Anyone Ever Taken 5g+ Niacinamide In One Sitting? Experiments 18
Orangeyouglad Any Ideas On Tolerating Niacinamide? Supplements, Pharmaceutical Drugs 5
haidut Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females Scientific Studies 6
W Niacinamide And Depression B3/Niacinamide 19
G Niacinamide Long Term Use Cortisol, Serotonin, Histamine 16
Ficini Niacinamide Topical Vs Oral Clarification B3/Niacinamide 2
SOMO Niacinamide Causing Skin Issues For Anyone Else? Supplements, Pharmaceutical Drugs 0
Batbat Niacinamide Inhibits Hair Growth B3/Niacinamide 7
Jewbermensch Niagen Worth It Over Niacinamide? Supplements, Pharmaceutical Drugs 22
E Issues After Taking High Dose Niacinamide Supplements, Pharmaceutical Drugs 17
Inaut I Think I’ve Finally Figured Out How To Use Niacinamide B3/Niacinamide 82
T How Much Aspirin And Niacinamide? Female 44 Yrs Fatigue And Heavy Menstruation Supplements, Pharmaceutical Drugs 5
A Niacin NOT The Same As Niacinamide, Acts Differently Regarding Lipolysis? Vitamins 13
Amazigh Niacinamide + Methyl Donor To Avoid Histamine Increase? Supplements, Pharmaceutical Drugs 6

Similar threads

Top