1. Cocoa Butter - Organic & Fair Trade Certified
    CLICK HERE!
    Dismiss Notice
  2. **NEW** BL11 - Orange, Red & Infrared Therapy Body Light
    CLICK HERE!
    Dismiss Notice
  3. Charcoal Soap - For Deep Cleansing
    CLICK HERE!
    Dismiss Notice
  4. Orange & Red Light Therapy Device - LGS1
    CLICK HERE!
    Dismiss Notice
  5. Organic Cocoa Powder
    CLICK HERE!
    Dismiss Notice
  6. Metabasoap - Handcrafted Soap
    CLICK HERE!
    Dismiss Notice
  7. Cascara Sagrada Powder From Farmalabor In Italy
    CLICK HERE!
    Dismiss Notice
  8. **NEW Mini Body Light** MBL1 - Orange & Red Light Therapy Mini Body Light
    CLICK HERE!
    Dismiss Notice

Niacinamide Reverses / Cures Duchenne Muscular Dystrophy

Discussion in 'Scientific Studies' started by haidut, Oct 20, 2016.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,590
    Gender:
    Male
    Location:
    USA / Europe
    It is well known even in mainstream medical circles that autoimmune conditions are characterized by greatly reduced levels of NAD. I posted a few studies in the past showing that raising NAD levels through supplementation of niacinamide can help virtually any autoimmune condition.
    This study takes the research a step further and suggests that even myopatic conditions maybe be due to NAD depletion and restoring NAD levels is therapeutic for those conditions. The study focused on the Duchenne dystrophy, but the principle is generic enough to apply to other conditions such as ALS, myasthenia gravis, Huntington disease, etc. What is even more amazing is that Duchenne is considered to be a genetic disorder, and as such largely untreatable. Until now, that is :):
    So much for genetics being your destiny...

    NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation | Science Translational Medicine
    http://medicalxpress.com/news/2016-10-vitamin-duchenne-muscular-dystrophy.html

    "...Johan Auwerx's team showed that the disease leads to a second cycle of events inside the cells, a series of reactions that exacerbate the disease's damaging effects. Several processes are at work in the second cycle. First, the 'primary' inflammation overactivates a certain gene, which then consumes a large quantity of an essential component called NAD+. This causes a shortage of NAD+ within the cell. But this component acts as a fuel for the powerhouse of cells, the mitochondria, which are especially important in muscle tissue. The NAD+ deficiency therefore weakens the muscle, an effect similar to that of mitochondrial deficiency in older people. Yet the consequences are even worse than they appear. Deprived of energy, the dysfunctional mitochondria aggravate the inflammation that causes muscle loss. So much for what could have initially appeared to be just a minor side effect of the disease."

    "...What if it were possible to reduce muscle inflammation - and thus muscle loss - by providing the worn-out mitochondria with fuel? That would mean administering nicotinamide riboside, the vitamin precursor of NAD+. This is the hypothesis that the researchers wanted to test after having already successfully investigated this vitamin's effect on muscle aging in their work on nutrition. They tried out their approach on animals, using C. elegans worms and mice that had been genetically modified to develop the disease. The effect was remarkable. When large doses of nicotinamide riboside were administered, the worms did not develop any of the disease's symptoms. The mice presented much lower muscular inflammation, and existing lesions were attenuated. "We have good reason to think that humans will also respond to this treatment and that we'll be able to reduce inflammation," said Auwerx, the lead author. "But we don't know to what extent. It's important to remember that we're not going after the primary cause of the disease, dystrophin deficiency." Which means it is difficult to predict the treatment's effectiveness. "Regardless, it would still be quite an accomplishment if we can prolong the patient's life by several years and increase their comfort."
     
  2. Tarmander

    Tarmander Member

    Joined:
    Apr 30, 2015
    Messages:
    2,205
    Gender:
    Male
    I have an auto immune and niacinamide has really stood the test of time. My regiment has changed around quite abit but I always take a little B3 each day.
     
  3. Dante

    Dante Member

    Joined:
    Sep 9, 2016
    Messages:
    458
    Gender:
    Male
    @haidut , this might sound little stupid but since methyl donors silence genes ( i know you are not a fan of methylation but it has it's place e.g the agouti mice study where prenatal nutrition destroyed the inheritance/genetics dogma kind of like what leonell strong did) so would adding a bit of methyl donors like Me-cobalmin can help in silencing this overacting gene ?
     
  4. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,590
    Gender:
    Male
    Location:
    USA / Europe
    How do you know that it will silence only that gene? If there was a drug that selectively delivered methyl groups only to that gene I would consider it, but there isn't AFAIK. Also, given the role of methylation in cancer and neurodegenartive conditions I would not mess with it. Methionine restriction is one of the few proven ways to extend maximum lifespan and greatly reduce risk of "aging" diseases like cancer and dementia. Niacinamide and glycine are methyl sinks, so this is probably a major reason behind their beneficial effects.
    Just my 2c.
     
  5. burtlancast

    burtlancast Member

    Joined:
    Jan 1, 2013
    Messages:
    2,196
    Good news.
    But Big Pharma will never allow a clinical trial for ANY vitamin to show improvement for ANY medical condition.
    They will cancel the human clinical trials or rig them.

    Because once a substance is officially deemed safe and effective for the treatment of a medical condition, the legislation allows doctors to use it potentially for ANY OTHER medical condition they see fit, without the opposition of any other organization being possible, unless it can prove the said utilization is detrimental to the patient.
    That's we call OFF LABEL usage.Off-label use - Wikipedia

    This is how once DMSO got approved for interstitial cystitis, independent cancer clinics started using it for cancer.
    Or how DMSA began being used to chelate mercury once it was deemed safe for lead detoxification.
     
  6. High_Prob

    High_Prob Member

    Joined:
    Mar 23, 2016
    Messages:
    194
    Gender:
    Male

    Haidut - Is Hydrogen Peroxide generation due to Methyl consumption something to be concerned about?

    https://www.ncbi.nlm.nih.gov/pubmed/22971213
     
  7. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,590
    Gender:
    Male
    Location:
    USA / Europe
    The study used both niacin and niacinamide. As you can see, only niacin led to increase H2O2 generation and niacinamide did not. Moreover, the doses used were absolutely massive - the lowest dose niacin used was 500mg/kg, which would equate to about 7g for a human. The higher doses are just mind boggling and unrealistic. The niacinamide was in doses of 2,000mg/kg, which corresponds to about 30g for a human, which is insanely high, and it still did not raise H2O2 or deplete glycogen. So, in the 1g -2g doses (or lower) that seems to be the upper limit for most users on the forum niacinamide is even less likely to cause any issues.
    Oh, and niacin depleted liver glycogen while niacinamide increased it. Yet another example of the different effects these two substances have. Finally, niacin caused hyperinsulinemia while niacinamide did not.
    "...Nicotinic acid decreased rat liver glycogen contents in a dose-dependent manner. In contrast, nicotinamide increased liver glycogen content. High cumulative nicotinic acid exposure showed a high level of plasma insulin."
     
  8. High_Prob

    High_Prob Member

    Joined:
    Mar 23, 2016
    Messages:
    194
    Gender:
    Male
    Thanks Haidut!
     
  9. TubZy

    TubZy Member

    Joined:
    Sep 30, 2016
    Messages:
    1,651
    Gender:
    Male
    Location:
    USA
    Thanks haidut, it could also be more effective with the niacinimide + MB stack for increasing NAD.
     
  10. sladerunner69

    sladerunner69 Member

    Joined:
    May 24, 2013
    Messages:
    2,789
    Gender:
    Male
    Occupation:
    Econ Student
    Location:
    Los Angeles
    Are you concerned that niacinimide will cause you to burn off your glucose to quickly? In combination with all of the other metabolic boosters you take I figure it would be all but impossible to consume enough glucose to keep your levels up.
     
  11. Texon

    Texon Member

    Joined:
    Nov 28, 2016
    Messages:
    325
    Gender:
    Male
    Methylation is a tricky issue, and I don't do well with methyl donors generally. For lowering homocysteine though, nothing seems to beat beet powder or daily doses of trimethylglycine for example. I absolutely cannot tolerate supplemental methyl folate, but historically I tend towards homocysteine levels of 13-16. I can intermittently tolerate methyl b12. The only thing that has helped to lower the number to 11 recently has been daily tmg powder (Jarrow in this case) of about 500 mgs/day which is pretty much the max for me. Any more than that makes me feel wired like crazy. This is a manifestation of a couple of COMT ++ snps which severely hamper breakdown of catecholamines. If anyone has a different approach, please share.
     
  12. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    15,590
    Gender:
    Male
    Location:
    USA / Europe
    Actually, high homocysteine seems to be mostly due to vitamin B6 deficiency. No need to supplement with methyl donors or folic acid and whatnot. Takign even 5mg P5P daily can bring homocysteine down by 40%+.
    Pyridoxal-5'-phosphate deficiency is associated with hyperhomocysteinemia regardless of antioxidant, thiamine, riboflavin, cobalamine, and folate s... - PubMed - NCBI
    Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcin... - PubMed - NCBI
    High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease. - PubMed - NCBI
     
  13. Texon

    Texon Member

    Joined:
    Nov 28, 2016
    Messages:
    325
    Gender:
    Male
    I've never seen p5p for this. I'll definitely try it and post results.
     
  14. Amazoniac

    Amazoniac Member

    Joined:
    Sep 10, 2014
    Messages:
    5,685
    Gender:
    Male
    Location:
    Uganda
    *Wrong thread. Could any divine force move this post to Niacinamide Or Just Plain Niacin?
     
Loading...