Niacinamide May Help Treat/reverse Heart Disease

haidut

Member
Joined
Mar 18, 2013
Messages
17,533
Location
USA / Europe
Yet another study showing the beneficial effects of improving mitochondrial function. This time, the study looked at heart health and found that NAD precursors like niacinamide and nicotinamide riboside (NR) can help prevent the decline in mitochondrial function and oxygen consumption driven by various stresses, including toxic assaults and calcium overload. The study showed that treatment for just 3 days with the HED of about 50mg/kg NR had reversed many of the damages that stress induced on cardiac cells. Given that niacinamide and NR are equally capable of raising NAD levels or stimulating UPRmt, the study effects should be reproducible by using plain niacinamide at the same doses as NR.

https://www.sciencedirect.com/science/article/pii/S0735109719306047?via=ihub

New data supports nicotinamide riboside’s potential heart health benefits

“…Nicotinamide riboside, a novel form of vitamin B3, may help maintain mitochondrial function by stimulating a cellular repair pathway, suggests a new study using ChromaDex’s Niagen product. Animal data published in the Journal of American College of Cardiology indicated that supplementation with nicotinamide riboside (NR) was associated with stimulation of a cellular response called the “mitochondrial unfolded protein response” (UPRmt) that helps maintain mitochondrial function. The study, conducted by principal investigators Prof. Ajay Shah and Dr Ioannis Smyrnias at Kings College London, also included a preliminary investigation of human heart tissue samples and found positive correlations between increased UPRmt activation and markers of healthy heart function. “NR supplementation is a new and exciting intervention that merits testing in the human treatment of heart failure and other cardiac conditions,” said Prof. Shah in a press release.

Mitochondria play a vital role for heart function by generating ATP to support the contraction and relaxation of the heart muscle. “Mitochondrial dysfunction is a central feature of heart failure by contributing to energetic dysfunction, oxidative stress, calcium dysregulation, and cardiomyocyte death, and is considered a potential therapeutic target,” explained the researchers. The results from the in vitro and mouse studies showed that stress led to a short-lived induction of UPRmt. By boosting UPRmt with NR “significantly mitigated the reductions in mitochondrial oxygen consumption induced by these stresses”, said the researchers. “Enhancement of the UPRmt ameliorates mitochondrial and contractile dysfunction, suggesting that it may serve an important protective role in the stressed heart,” concluded the researchers.
 

Kyle Bigman

Member
Joined
Jul 9, 2018
Messages
275
@haidut , does sugar deplete NAD+? I read fructose depletes it.

Also, I continuously read articles about how Sirt1 inhibition is bad and causes aging. Maybe this is true, but maybe niacinamide does not inhibit sirt1 in vivo, perhaps it actually stimulates it like reservatrol?
 
Similar threads
Thread starter Title Forum Replies Date
haidut Fatty Acid Oxidation (FAO) Makes Cancer Therapy-resistant, Niacinamide May Help Scientific Studies 0
haidut Niacinamide may treat ALS by improving energetic state Scientific Studies 0
haidut Niacinamide may treat depression by improving energetic state Scientific Studies 8
haidut Niacinamide (vitamin B3) May Cure HIV (human Study) Scientific Studies 9
haidut Niacinamide May Treat Fibrotic Eye Disease And Prevent Vision Loss Scientific Studies 5
haidut Dietary Niacinamide (B3) Deficiency May Be A Cause Of Schizophrenia Scientific Studies 7
haidut Niacinamide May Restore Female Fertility In Old Age Scientific Studies 17
haidut Niacinamide May Improve Symptoms Of ALS Scientific Studies 1
Koveras Tuberculosis Depletes NAD+ (and Niacinamide May Be Able To Treat It) Scientific Studies 1
haidut Niacinamide May Treat (acute) Kidney Failure (AKI) - Human Study Scientific Studies 5
haidut Niacinamide May Be A Viable Treatment For Parkinson Disease (PD) Scientific Studies 8
haidut Niacinamide Lowers BP, May Reverse CVD And Reduce Heart Attack Risk By 25% Scientific Studies 14
haidut Niacinamide May Treat Brain Cancer (glioblastoma) Scientific Studies 8
haidut Niacinamide And Doxycycline May Treat Alzheimer Disease (AD) Scientific Studies 7
haidut Niacinamide May Treat ALS (and Stroke) Scientific Studies 6
haidut High-dose Vitamin C Or Niacinamide May Treat Advanced Colon Cancer Scientific Studies 12
haidut Niacinamide May Prevent Melanoma Scientific Studies 4
haidut Niacinamide May Fully Prevent Miscarriages And/or Birth Defects Scientific Studies 1
haidut Rheumatoid Arthritis Is A Metabolic Disease; Vitamin K And Niacinamide May Treat It Scientific Studies 57
haidut Niacinamide May Treat Hepatitis B Scientific Studies 1
haidut Niacinamide May Be Able To Treat Both HIV And Tuberculosis Scientific Studies 2
ddjd Taurine causes nerve pain issues. Niacinamide heals. What's the mechanism?? Ask For Help or Advice 6
C Whats the verdict on Niacin/Niacinamide? Supplements, Pharmaceutical Drugs 31
IROM Alpecin shampoo: Caffeine, Taurine and Niacinamide (are corporations on to Peating?) Hair & Nails 9
youngsinatra High Dose Niacinamide Self-Experiment. Experiments 29
haidut Glaucoma likely a metabolic disease, treatable by pyruvate and/or niacinamide Scientific Studies 2
S Aspirin, niacinamide and eye bags Supplements, Pharmaceutical Drugs 7
J Niacinamide Ask For Help or Advice 15
SOMO Niacinamide + Vit C = Niacin? Ask For Help or Advice 0
Razvan Niacinamide Help Ask For Help or Advice 1
pauljacob Can I Break Open A Niacinamide, Pregnenolone Capsule? Supplements, Pharmaceutical Drugs 4
charlie Vitamin B3 (Niacinamide) Shows Promise For Glaucoma Patients In Clinical Trial Scientific Studies 2
snacks Niacinamide And Dandruff Skin 2
ddjd Niacinamide Great For Sleep. Niacin Terrible. Why? Ask For Help or Advice 10
Hgreen56 Niacinamide Inhibits Fatloss And Niacin Improve It? Supplements, Pharmaceutical Drugs 10
ampersand Ataxia, Iron, Methylene Blue, Niacinamide Supplements, Pharmaceutical Drugs 2
C Aspirin/Niacinamide/Pyrucet Supplements, Pharmaceutical Drugs 7
meatbag Has Anyone Ever Taken 5g+ Niacinamide In One Sitting? Experiments 18
Orangeyouglad Any Ideas On Tolerating Niacinamide? Supplements, Pharmaceutical Drugs 5
haidut Low-dose (but Not High) Niacinamide Reverses Reproductive Decline In Old Females Scientific Studies 6
W Niacinamide And Depression B3/Niacinamide 19
G Niacinamide Long Term Use Cortisol, Serotonin, Histamine 16
Ficini Niacinamide Topical Vs Oral Clarification B3/Niacinamide 2
SOMO Niacinamide Causing Skin Issues For Anyone Else? Supplements, Pharmaceutical Drugs 0
Batbat Niacinamide Inhibits Hair Growth B3/Niacinamide 7
Jewbermensch Niagen Worth It Over Niacinamide? Supplements, Pharmaceutical Drugs 22
E Issues After Taking High Dose Niacinamide Supplements, Pharmaceutical Drugs 18
Inaut I Think I’ve Finally Figured Out How To Use Niacinamide B3/Niacinamide 82
T How Much Aspirin And Niacinamide? Female 44 Yrs Fatigue And Heavy Menstruation Supplements, Pharmaceutical Drugs 5
A Niacin NOT The Same As Niacinamide, Acts Differently Regarding Lipolysis? Vitamins 13

Similar threads

Top