protective

  1. haidut

    Obesity "paradox" Strikes Again - Protection Against COVID-19

    I suspect this one will not go down will with the "lean is always good" crowd, which consists predominantly of members of the medical profession. Aside from all the health risks of obesity for pretty much any chronic disease, the news over the last 6 months have been replete with warning from...
  2. haidut

    Aspirin Protects Mitochondria From Inflammation And Aging

    The good news about aspirin just never seem to stop. While the anti-inflammatory effects of aspirin are well-known, mainstream medicine like to explain them away with the limited (and frankly primitive) mechanism of COX inhibition alone. If aspirin happens to achieve some other beneficial health...
  3. haidut

    Natural Progesterone (but Not Synthetic Progestins) Has Potent Anti-hypertensive Effects

    As many readers already know, synthetic estrogens and progestins currently dominate the market for female reproductive health. These chemicals are in everything from birth control pills, to drugs for "treating" endometriosis, to drugs for menopausal symptoms, to treating neurodegenerative...
  4. haidut

    Aspirin May Protect Lungs From Air Pollution

    It seems that there is nothing mighty aspirin cannot do. Just recently, I posted about its ability to treat (and, more importantly, potentially have curative effect) erectile dysfunction (ED) at least as effectively as established drugs such as Viagra, Levitra, Cialis, etc. yet with much fewer...
  5. haidut

    Supplementation With (long Chain) Saturated Fats Protects Liver From Alcohol

    As many of my readers already know, there are a number of human studies, going back to at least the 1960s, demonstrating that supplementation with saturated fats (SFA) protects the liver from damage induced by alcohol. I fact, supplementation with SFA not only prevents alcohol-induced liver...
  6. haidut

    Niacinamide May Help Treat/reverse Heart Disease

    Yet another study showing the beneficial effects of improving mitochondrial function. This time, the study looked at heart health and found that NAD precursors like niacinamide and nicotinamide riboside (NR) can help prevent the decline in mitochondrial function and oxygen consumption driven by...
  7. haidut

    Another Obesity Paradox - Higher BMI Linked To Lower Breast Cancer Risk

    I am sure this study will generate a lot of controversy, but the reductions in risk are pretty significant and hard to argue with. The fact that there was no threshold at which BMI started being protective suggests that the protective effect is indeed drive by increased mass. The study only...
  8. haidut

    The Protein In Fish, Not Omega-3, May Be Protective Against Brain Disease

    Over the last 2 decades thousands of studies were published on the purported benefits of omega-3 fats commonly found in cold water fish. However, every large human trial with omega-3 either failed to find benefit or even found increased risk of harm. Despite that fact, there is very strong...
  9. haidut

    Western Diet Or SFA Strikingly Protective Against Colon Cancer And Mortality

    No, this is not an April's fool joke. Kind of surprising that this study did not make front page news on MSM, but it may be better this way as the study will probably quickly get retracted if it becomes more popular. Several important findings in this study. The first one is probably the...
  10. haidut

    PUFA Increases Alcohol Damage By Increasing Cell Fluidity; SFA Are Protective

    Peat has written a number of times on the synergies of PUFA with ethanol and endotoxin on causing liver and systemic damage. In one of his articles he opined that in the absense of PUFA/iron ethanol would likely not cause much harm. He also wrote about the protective effects of saturated fats...
  11. haidut

    Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

    The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg...
  12. haidut

    Strong Androgens (DHT) As Treatment For CVD, Obesity And Metabolic Syndrome

    The study used DHT as the active drug but since the positive effects were due to androgen receptor agonism, any other strong androgen agonist should do. I think the lack of estrogenicity also contributed to the benefits of DHT observed in this study, so this would explain the mixed results with...
  13. K

    Emergency: Studies On Radiation Protective Substances?

    The thread is mainly about the scientific studies behind the x-ray protective substances that @haidut have suggested in another thread: methylene blue, DHEA, niacinamide, thyroid, caffeine and cyproheptadine. A family member needs a job but the job requires him to do a physical check up with...
  14. haidut

    Pregnenolone (and DHEA) May Protect From Heart Disease

    In some of his recent emails to people Ray recommended pregnenolone as a substance that lowers prostaglandins and inflammation. This mechanism of action also happens to be the officially proposed one for the benefits in heart disease seen with aspirin use. I was looking for the studies to...
  15. haidut

    Safety Of Long-term Use Of DMSO As A Solvent

    I wanted to post this even though it won't change the mind of DMSO opponents. The topic of DMSO safety has come up multiple times among scientists using it as a solvent for delivery of chemicals in vivo studies and so I did some digging and found some interesting data point. First, DMSO used in...
  16. haidut

    Glycine Can Completely Prevent Esophagus Damage Caused By GERD

    As discussed in another thread by forum member @denise, using PPI drugs is really to no benefit for preventing inflammation of the esophagus and subsequent development of Barret's or even cancer. The GERD damage is based on an inflammatory reaction, as I mentioned in another post. As such, it...
  17. haidut

    5α-Dihydroprogesterone (5α-DHP) - The Primary Progestogen Neurosteroid

    It has been shown that progesterone rapidly metabolizes into more saturated metabolites such as 5α-Dihydroprogesterone (5α-DHP) and tetrahydroprogesterone (also known as allopregnanolone or Allo). The enzyme 5-AR is the one responsible for the saturation, just as it is responsible for the...
  18. haidut

    Being Obese / Overweight Protects Against Dementia In The Elderly

    Another example of the "obesity paradox", this time the authors themselves call the extra weight being protective and it was not something deduced by the public by reading the study. Dramatic decline in dementia seen among older adults in the US "...One possible factor is education. The older...
  19. haidut

    Low-dose Glycine As Stroke Treatment In Humans

    The mainstream therapy for (non-hemorrhaging) stroke is a IV anticoagulants like warfarin, or a baby aspirin within the first few hours of getting stroke symptoms while the person is on her/his way to the hospital. These two studies show that sublingual glycine in a dose of 1g-2g within the...
  20. haidut

    DHEA Protects From Endotoxin Effects And Lethality

    Sepsis is the leading cause of death in patients hospitalized for infections. There is no accepted treatment, at least officially, that can change the course of the sepsis for the better. This study shows that a single HED dose of as little as 5mg - 7mg daramatically increased survival from a...
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