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Low-dose Glycine As Stroke Treatment In Humans

haidut

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Joined
Mar 18, 2013
Messages
19,276
Location
USA / Europe
The mainstream therapy for (non-hemorrhaging) stroke is a IV anticoagulants like warfarin, or a baby aspirin within the first few hours of getting stroke symptoms while the person is on her/his way to the hospital.
These two studies show that sublingual glycine in a dose of 1g-2g within the first 6 hours after having a ischemic stroke can effectively reduce mortality and morbidity even in the absence of anti-coagulant therapy. Given that glycine has strong protective effects against excessive bleeding I am wondering if glycine can also be used in bleeding strokes as well.
Not bad of an achievement for the humble, cheap, smallest amino acid.

Neuroprotective effects of glycine for therapy of acute ischaemic stroke. - PubMed - NCBI
"...Thus, the trial suggests that sublingual application of 1.0-2. 0 g/day glycine started within 6 h after the onset of acute ischaemic stroke in the carotid artery territory is safe and can exert favourable clinical effects. These results will be verified in further trials with a larger number of patients."

[Neuroprotective effects of glycine in the acute period of ischemic stroke]. - PubMed - NCBI
"...Both the efficiency of glycine in the acute period of hemispheric ischemic stroke and mechanisms of its action were studied in a double blind placebo-controlled trial including 200 patients. Orgogozo's and Scandinavian scales for objective assessment of the condition severity and of a degree of neurologic deficiency, and Bartel's scale--for evaluation of functional recovery were used and measurements were made of the levels of autoantibodies to the structural component of glutamate NMDA-receptors in blood serum and concentrations of neurotransmitter amino acids and of the products of lipid peroxidation in cerebrospinal fluid. Sublingual glycine application in daily dose of 1-2 g was found effective beginning with the first 6 hours of the stroke development during 5 days. Multicomponent neuroprotective action of glycine was established directed at correction of the unbalance between stimulating and inhibiting aminoacidergic neurotransmitters, as well as at a decrease of excitotoxicity and oxidant stress."
 

ampersand

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Joined
Jul 4, 2015
Messages
75
Can glycine be dissolved in DMSO? My mom had a stroke. While it was happening her mouth was clenched tight and she couldn't swallow. Any thoughts about topical application? I'm trying to think of things to have on hand in case of another stroke.
 

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