• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Glycine Can Completely Prevent Esophagus Damage Caused By GERD

haidut

Member
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
As discussed in another thread by forum member @denise, using PPI drugs is really to no benefit for preventing inflammation of the esophagus and subsequent development of Barret's or even cancer. The GERD damage is based on an inflammatory reaction, as I mentioned in another post. As such, it would be plausible that anti-inflammatory agents could prevent that damage caused by GERD. The study below shows that it is possible to completely prevent the damage and inflammation caused by GERD by simply ingesting a dose of abut 10g glycine. That would correspond to about 40g gelatin, which is quite doable. Interestingly, the NSAID indomethacin had NO protective effect, while glycine in the HED of about 10g provided complete protection.
So, maybe the next time your doctor suggests PPI you can show him/her this and wait for the tirade :):

Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats. - PubMed - NCBI
"...To further investigate whether the protective effect of L-arginine is due to its physicochemical properties or mediated by its biological actions, we repeated the same experiments using D-arginine. As shown in Figure 3B, D-arginine (250 mg/kg) also provided good protection against the acid reflux esophagitis, the inhibition being 89.0%. Likewise, glycine (250~750 mg/kg) dose-dependently reduced the severity of the esophagitis, and the lesion score at 250 and 500 mg/kg was 37.1±14.7 mm2 and 12.6±4.1 mm2, respectively (Figure 4A). Complete inhibition by glycine was observed at 750 mg/kg (Figure 4B)."
 
Joined
Dec 25, 2014
Messages
1,045
Does it reverse the damage?

well if it's inflammation (as opposed to burn from acid) then stopping the inflammation and allowing the tissue to heal would fix the damage. But I'm not sold on the idea, acid definitely has an effect on the esophagus.
 

richofden

Member
Joined
Feb 2, 2020
Messages
58
well if it's inflammation (as opposed to burn from acid) then stopping the inflammation and allowing the tissue to heal would fix the damage. But I'm not sold on the idea, acid definitely has an effect on the esophagus.
Hi Pimpnamedraypeat, I´m not sure what you mean by this. Do you think there´s better things to do?
 
Similar threads
Thread starter Title Forum Replies Date
zarrin77 Glycine Completely Protects Liver Cells From Apoptosis Due To Iron Scientific Studies 1
Brandin Glycine no L or D versions? Ask For Help or Advice 2
T Glycine Toxic At High Doses Protein 4
J Glycine and taurine Ask For Help or Advice 9
J Glycine prolactin Ask For Help or Advice 1
md_a Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix Scientific Studies 1
C Does muscle meat have more Glycine ? Diet 16
Mito Anti-inflammatory activity of ivermectin in late-stage COVID-19 may reflect activation of systemic glycine receptors Miscellaneous Health Discussions 7
E Does anyone know if glycine supplement raise hemoglobin? Ask For Help or Advice 1
E Coke + niacinamide + glycine Ask For Help or Advice 3
R Gelatin vs pork crackle for glycine? Amino Acids 10
R May need higher dose of glycine (10g)? Amino Acids 0
R Low-dose copper with glycine and proline or gelatin for collagen? Ask For Help or Advice 2
haidut Glycine (and leucine) can treat fatty liver (NAFLD and NASH) Scientific Studies 3
haidut Glycine has a universal anti-viral effect Scientific Studies 38
Lokzo Glycine Reduces NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome - 2020 Supplements, Pharmaceutical Drugs 21
Ras Glycine Ameliorates NAFLD By Modulating FAO, Glutathione Synthesis, And The Gut Microbiome Amino Acids 0
johnwester130 Lamb Lungs Surprisingly High In Glycine Meat, Organ Meat, Gelatin, Seafood 5
johnwester130 The Ultiamte Simple Mouthwash With Glycine Powder Oral Health 39
Amazigh Astronomers Report They’ve Detected The Amino Acid Glycine In The Atmosphere Of Venus Miscellaneous Health Discussions 12
M Percentage Of Glycine In Chelated Calcium Ask For Help or Advice 1
M A Choline-rich Diet (and Glycine) Improves Survival In A Rat Model Of Endotoxin Shock Scientific Studies 0
M Bad Experience With Glycine Ask For Help or Advice 19
Velve921 What Does Everyone Thing Of Sooma For Sleep? It Has Glycine Ask For Help or Advice 0
explosionlord Aspirin + K2 + Glycine Poor Reaction; Anybody Else? Supplements 8
A Gelatin/Glycine In Ground Beef Meat, Organ Meat, Gelatin, Seafood 7
V Foods With A Good Glycine / Methionine Ratio Diet 1
M Your Glycine Experiences? Ask For Help or Advice 35
Hans The Peat Ratio Of Foods (Glycine Vs Methionine, Cysteine And Tryptophan) Discussing Dietary Models 34
M Do You Feel A Difference From Taking Glycine Or Gelatin Or Aspirin? Ask For Help or Advice 5
Hgreen56 Why Are Gelatin And Glycine Recommended If Glycine Increases Serotonin Levels? Supplements, Pharmaceutical Drugs 10
zarrin77 Glycine (and Serine) Have Potent “anti-depressive” Effects In Rodent Endotoxin Model Scientific Studies 1
H Coffee Without Glycine Allergy Diet 2
Ravenslore Why Does My Hair Fall Out If I Don't Take Glycine Daily? Ask For Help or Advice 24
berk Someone Experienced Energy From Glycine? Metabolism 22
michael94 Brain Glycine Levels Not Always Limited To Glycine Intake Meat, Organ Meat, Gelatin, Seafood 2
Jib High-Dose Glycine For OCD And BDD Scientific Studies 9
zarrin77 Glycine Protects Liver Cells From Mercury Toxicity Scientific Studies 1
JoshuaD Glycine And Stress Cortisol, Serotonin, Histamine 44
S Mineral Glycine Chelates Taken In The Morning? Supplements 0
L How To Increase Endogenous Glycine Synthesis? Metabolism 8
GorillaHead Once Again Mitochondrial Dysfunction At The Center Of AGING. Glycine Supplementation Huge Scientific Studies 5
I Glycine Digestion 13
_lppaiva Glycine As A Temporary Alternative To Gelatin, Since No Good Brands Are Available? Supplements, Pharmaceutical Drugs 29
M Taurine Vs. Glycine Regarding Gallstones? Supplements 6
olive Gelatin Enhances Non-gene Iron Uptake, Glycine Does Not Scientific Studies 3
C Pregnenolone + Taurine + Glycine Pregnenolone 6
Gadsie Glycine Inhibits Formation Of Blood Vessels In (colon) Tumors Scientific Studies 1
L Oral Exposure To The Free Amino Acid Glycine Inhibits The Acute Allergic Response In A Model Of Cow' Scientific Studies 13
magnesiumania Glycine, Brands, Dosage Amino Acids 27

Similar threads

Top