• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

haidut

Member
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg daily.

http://www.nature.com/articles/srep43846
IU-led brain study suggests new ways to protect against neurodegeneration : IU Bloomington Newsroom: Indiana University Bloomington
IU study finds caffeine boosts enzyme that could protect against dementia: IU Bloomington Newsroom: Indiana University Bloomington

"... A study by Indiana University researchers has identified 24 compounds -- including caffeine -- with the potential to boost an enzyme in the brain shown to protect against dementia. The protective effect of the enzyme, called NMNAT2, was discovered last year through research conducted at IU Bloomington. The new study appears today in the journal Scientific Reports. "This work could help advance efforts to develop drugs that increase levels of this enzyme in the brain, creating a chemical 'blockade' against the debilitating effects of neurodegenerative disorders," said Hui-Chen Lu, who led the study. Lu is a Gill Professor in the Linda and Jack Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, a part of the IU Bloomington College of Arts and Sciences. Previously, Lu and colleagues found that NMNAT2 plays two roles in the brain: a protective function to guard neurons from stress and a “chaperone function” to combat misfolded proteins called tau, which accumulate in the brain as "plaques" due to aging. The study was the first to reveal the "chaperone function" in the enzyme. Misfolded proteins have been linked to neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases, as well as amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease. Alzheimer’s disease, the most common form of these disorders, affects over 5.4 million Americans, with numbers expected to rise as the population ages."
 

tca300

Member
Joined
Aug 29, 2013
Messages
1,570
Do you think coffee intake and its protective effects are basically dose dependent? ( except for very high doses obviously ) Thank you!
@haidut
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
Do you think coffee intake and its protective effects are basically dose dependent? ( except for very high doses obviously ) Thank you!
@haidut

I think caffeine has a U-shape curve. Peat said something similar recently in regards to the higher doses having non-metabolic effects. The best effects for the liver are probably in the 100mg - 200mg range daily and are unlikely to cause much stress to the organism. For prevention of brain issues, 100mg - 200mg is probably enough. For treatment, higher doses in the 600mg+ daily may be needed.
 

docall18

Member
Joined
Dec 11, 2013
Messages
329
Location
LA
I think caffeine has a U-shape curve. Peat said something similar recently in regards to the higher doses having non-metabolic effects. The best effects for the liver are probably in the 100mg - 200mg range daily and are unlikely to cause much stress to the organism. For prevention of brain issues, 100mg - 200mg is probably enough. For treatment, higher doses in the 600mg+ daily may be needed.

Mm 100mg-200mg is a very low dose. Approx one cup of coffee per day.

I see previous threads recommending higher doses for a range of pro metabolic uses. I presume for the average person that can handle 500-1000mg of caffeine/day, this would be a preferable dose?
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
Mm 100mg-200mg is a very low dose. Approx one cup of coffee per day.

I see previous threads recommending higher doses for a range of pro metabolic uses. I presume for the average person that can handle 500-1000mg of caffeine/day, this would be a preferable dose?

Sure, use as much as you feel good with. The higher doses are probably more dopaminergic and anti-fibrotic.
 
Joined
Aug 1, 2016
Messages
40
Sure, use as much as you feel good with. The higher doses are probably more dopaminergic and anti-fibrotic.

So, I've just been diagnosed with ALS. At first they thought it was MMN, but as breathing became involved, the diagnosis was looked at more carefully. I started on a ketogenic diet, also including bulletproof coffee. After one week doing the coffee, my ear ringing went away for about a week. I stopped the coffee cuz I don't really like it without cream(even with the oil and butter), as I'm avoiding dairy currently. Ringing came back.
I'm very uncertain about the keto diet. My son got so much better doing it, and he felt my raw milk was not good for me. I love it though and it's been hard. This last week, I've had horrible cotton mouth, and I understand is a part of keto. Wake up multiple times because it's so bad, and no moisture to form a spit wad is there. I'm drinking plenty of water...more than I feel I should, especially after reading Matt Stone on that subject. I realize there's a lot more to healing ALS than coffee, but would upping it seriously help? I know coffee decreases estrogen(I'm 62), and I know hormones play in. Is Ray still doing consults?
 

Regina

Member
Joined
Aug 17, 2016
Messages
3,916
Location
Chicago
So, I've just been diagnosed with ALS. At first they thought it was MMN, but as breathing became involved, the diagnosis was looked at more carefully. I started on a ketogenic diet, also including bulletproof coffee. After one week doing the coffee, my ear ringing went away for about a week. I stopped the coffee cuz I don't really like it without cream(even with the oil and butter), as I'm avoiding dairy currently. Ringing came back.
I'm very uncertain about the keto diet. My son got so much better doing it, and he felt my raw milk was not good for me. I love it though and it's been hard. This last week, I've had horrible cotton mouth, and I understand is a part of keto. Wake up multiple times because it's so bad, and no moisture to form a spit wad is there. I'm drinking plenty of water...more than I feel I should, especially after reading Matt Stone on that subject. I realize there's a lot more to healing ALS than coffee, but would upping it seriously help? I know coffee decreases estrogen(I'm 62), and I know hormones play in. Is Ray still doing consults?
I think there are threads here specifically discussing ALS.
For tinnitus, Haidut has mentioned niacinamide, taurine and phosphitydlecholine.
I don't think a keto diet is recommended.
But diamant should be nice as well as pregnenolone and anti-serotonin drugs.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
So, I've just been diagnosed with ALS. At first they thought it was MMN, but as breathing became involved, the diagnosis was looked at more carefully. I started on a ketogenic diet, also including bulletproof coffee. After one week doing the coffee, my ear ringing went away for about a week. I stopped the coffee cuz I don't really like it without cream(even with the oil and butter), as I'm avoiding dairy currently. Ringing came back.
I'm very uncertain about the keto diet. My son got so much better doing it, and he felt my raw milk was not good for me. I love it though and it's been hard. This last week, I've had horrible cotton mouth, and I understand is a part of keto. Wake up multiple times because it's so bad, and no moisture to form a spit wad is there. I'm drinking plenty of water...more than I feel I should, especially after reading Matt Stone on that subject. I realize there's a lot more to healing ALS than coffee, but would upping it seriously help? I know coffee decreases estrogen(I'm 62), and I know hormones play in. Is Ray still doing consults?

It is pretty well established in research circles that ALS is a mitochondrial disease with heavy inflammation component. I posted a few studies about that and a recent study showed that copper can treat ALS as it restores cytochrome C activity.
More evidence that diseases like ALS are mitochondrial
Shockingly Successful Trial Shows Copper Dissolved In Dmso Treats Als

Aside from copper, other things that directly target and restore cytochrome C activity include thyroid, and methylene blue. So, a combination of copper and methylene blue seems like something that should be safe to try. Peat wrote about a friend of his who has been living with ALS for 20+ years and keeps it under control with 3g-4g aspirin daily. When he stops the aspirin for a week the symptoms start to come back and when he restarts it the symptoms disappear. His doctor tried to illegally sequence his genome as he thought this case is impossible as the condition is quite clearly ALS yet this guy continues to live without much issues in walking, eating and breathing.
Finally, I recently posted that ALS is characterized by hypogonadism and increased adrenal activity (so a condition of high stress) and steroid treatment with T or DHT reversed symptoms in animal models. Keeping stress low and sugar intake high may help at least slow progression.
Stress May Be The Primary Cause Of Als
High Sugar Diet Prolongs Survival In ALS Patients

If you have not yet done so I would do a full steroid panel, including vitamin D and cortisol and if hypogonadism is confirmed maybe ask the doctor for low dose bioidentical T prescription. Pregnenolone, progesterone and DHEA, as well as androsterone may also help but there is not much clinical evidence for them.
Cholesterol May Protect The Brain From Diseases Like Als

Btw, I don't think the tinnitus is related to the ALS diagnosis. It is usually due to gut irritation. Did the doctor say tinnitus is a symptom of ALS?
 
Joined
Aug 1, 2016
Messages
40
It is pretty well established in research circles that ALS is a mitochondrial disease with heavy inflammation component. I posted a few studies about that and a recent study showed that copper can treat ALS as it restores cytochrome C activity.
More evidence that diseases like ALS are mitochondrial
Shockingly Successful Trial Shows Copper Dissolved In Dmso Treats Als

Aside from copper, other things that directly target and restore cytochrome C activity include thyroid, and methylene blue. So, a combination of copper and methylene blue seems like something that should be safe to try. Peat wrote about a friend of his who has been living with ALS for 20+ years and keeps it under control with 3g-4g aspirin daily. When he stops the aspirin for a week the symptoms start to come back and when he restarts it the symptoms disappear. His doctor tried to illegally sequence his genome as he thought this case is impossible as the condition is quite clearly ALS yet this guy continues to live without much issues in walking, eating and breathing.
Finally, I recently posted that ALS is characterized by hypogonadism and increased adrenal activity (so a condition of high stress) and steroid treatment with T or DHT reversed symptoms in animal models. Keeping stress low and sugar intake high may help at least slow progression.
Stress May Be The Primary Cause Of Als
High Sugar Diet Prolongs Survival In ALS Patients

If you have not yet done so I would do a full steroid panel, including vitamin D and cortisol and if hypogonadism is confirmed maybe ask the doctor for low dose bioidentical T prescription. Pregnenolone, progesterone and DHEA, as well as androsterone may also help but there is not much clinical evidence for them.
Cholesterol May Protect The Brain From Diseases Like Als

Btw, I don't think the tinnitus is related to the ALS diagnosis. It is usually due to gut irritation. Did the doctor say tinnitus is a symptom of ALS?
No, they didn't. I could agree it is the gut. Thank you for all your help. I will get back with you on it as I digest it. So, to start with, should I just try aspirin? How does that work? My nerve study shows that my brain signals the nerve but the nerve is not carrying the signal all the way to the muscle. Would ending the inflammation cause the nerves abd makes to communicate again? I'm so clueless...
 
Last edited:
Joined
Aug 1, 2016
Messages
40
It is pretty well established in research circles that ALS is a mitochondrial disease with heavy inflammation component. I posted a few studies about that and a recent study showed that copper can treat ALS as it restores cytochrome C activity.
More evidence that diseases like ALS are mitochondrial
Shockingly Successful Trial Shows Copper Dissolved In Dmso Treats Als

Aside from copper, other things that directly target and restore cytochrome C activity include thyroid, and methylene blue. So, a combination of copper and methylene blue seems like something that should be safe to try. Peat wrote about a friend of his who has been living with ALS for 20+ years and keeps it under control with 3g-4g aspirin daily. When he stops the aspirin for a week the symptoms start to come back and when he restarts it the symptoms disappear. His doctor tried to illegally sequence his genome as he thought this case is impossible as the condition is quite clearly ALS yet this guy continues to live without much issues in walking, eating and breathing.
Finally, I recently posted that ALS is characterized by hypogonadism and increased adrenal activity (so a condition of high stress) and steroid treatment with T or DHT reversed symptoms in animal models. Keeping stress low and sugar intake high may help at least slow progression.
Stress May Be The Primary Cause Of Als
High Sugar Diet Prolongs Survival In ALS Patients

If you have not yet done so I would do a full steroid panel, including vitamin D and cortisol and if hypogonadism is confirmed maybe ask the doctor for low dose bioidentical T prescription. Pregnenolone, progesterone and DHEA, as well as androsterone may also help but there is not much clinical evidence for them.
Cholesterol May Protect The Brain From Diseases Like Als

Btw, I don't think the tinnitus is related to the ALS diagnosis. It is usually due to gut irritation. Did the doctor say tinnitus is a symptom of ALS?
Additionally, I'm scared to death of sugar, even though I read a lot on Peat's site. As I upped my dairy, calories, sugar, resistant starch, my gut went way out and my central nervous system became involved. My diagnosis changed from MMN to ALS...I know there are so many factors that could play in and make my statements to that effect wrong, so i really need someone to consult with. I'm too stressed to do the research any more. Is Peat still advising? If not, who do you recommend?
 

Regina

Member
Joined
Aug 17, 2016
Messages
3,916
Location
Chicago
Additionally, I'm scared to death of sugar, even though I read a lot on Peat's site. As I upped my dairy, calories, sugar, resistant starch, my gut went way out and my central nervous system became involved. My diagnosis changed from MMN to ALS...I know there are so many factors that could play in and make my statements to that effect wrong, so i really need someone to consult with. I'm too stressed to do the research any more. Is Peat still advising? If not, who do you recommend?
Resistant starch??
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
Additionally, I'm scared to death of sugar, even though I read a lot on Peat's site. As I upped my dairy, calories, sugar, resistant starch, my gut went way out and my central nervous system became involved. My diagnosis changed from MMN to ALS...I know there are so many factors that could play in and make my statements to that effect wrong, so i really need someone to consult with. I'm too stressed to do the research any more. Is Peat still advising? If not, who do you recommend?

I think Peat still consults, so you can email him.
 

haidut

Member
Thread starter
Joined
Mar 18, 2013
Messages
18,214
Location
USA / Europe
No, they didn't. I could agree it is the gut. Thank you for all your help. I will get back with you on it as I digest it. So, to start with, should I just try aspirin? How does that work? My nerve study shows that my brain signals the nerve but the nerve is not carrying the signal all the way to the muscle. Would ending the inflammation cause the nerves abd makes to communicate again? I'm so clueless...

I think you should take these studies to your doctor and ask for treatment. The copper treatment is probably already available as an experimental protocol, which your doctor may be willing to administer.
 
Similar threads
Thread starter Title Forum Replies Date
haidut Caffeine protects against breast cancer by lowering estrogen Scientific Studies 6
haidut Coffee (caffeine) protects against melanoma Scientific Studies 6
L Caffeine Protects Dopaminergic Neurons From Dopamine-Induced Neurodegeneration Via Synergistic Adeno Scientific Studies 2
haidut Caffeine protects the gastric mucosa from NSAIDs and alcohol Scientific Studies 10
haidut Caffeine Protects Blood-brain Barrier From Endotoxin Damage Scientific Studies 4
G Caffeine, Synchronicity and Luck Miscellaneous 1
Mauritio Testosterone, progesterone, caffeine and thymoquinone inhibit Coronavirus through HSP-binding Scientific Studies 7
E Mind the caffeine Caffeine 8
rothko Health Natura Caffeine and Aspirin Water Solubility? Ask For Help or Advice 2
F Did anyone noticed that Thyroid meds work better with coffee/caffeine? Ask For Help or Advice 20
F Your experience with coffee/caffeine in context of hypothyroidism? Ask For Help or Advice 15
A Caffeine is great but constantly pushes forward sleep cycle - what to do? Ask For Help or Advice 34
Hgreen56 How much caffeine from coffee powder goes through a coffee filter? Coffee 7
U Is caffeine intolerance good or bad sign? Coffee 5
cupofcoffee Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging Coffee 16
Lokzo Teacrine Benefits: An Alternative To Caffeine/Coffee Supplements 0
C How to deal with the negative side effects of caffeine ? Ask For Help or Advice 3
B Confused about Caffeine Ask For Help or Advice 9
ddjd insomnia from caffeine disappears on fruitarian diet Ask For Help or Advice 83
Mauritio Cistanche more effective at decreasing lipid peroxidation and free radicals than Vitamin E and Caffeine Science 66
TopGun1911 How do you deal with caffeine withdrawals? Ask For Help or Advice 3
B Caffeine irratible? Ask For Help or Advice 7
B Caffeine irratible, trouble sleeping? Caffeine 14
IROM Alpecin shampoo: Caffeine, Taurine and Niacinamide (are corporations on to Peating?) Hair & Nails 9
G Starting Caffeine - Lots of Health Problems - Asthma, Erectile Dysfunction, Hypertonic Pelvic Floor, Hair Loss, Anxiety/Depression Caffeine 80
Nuri55 Can I Dissolve Caffeine Powder In Boiled Water And Then Apply On My Scalp? Hair & Nails 22
M Post Caffeine Symptoms Symptoms, Causes 13
U Anyone Had Health Improvements From Reducing Caffeine Intake? Coffee 42
M How To Treat Leaky Blood-brain-barrier If One Is Sensitive To Caffeine Pill? Ask For Help or Advice 3
H Caffeine Giving Me Anxiety Ask For Help or Advice 1
ScurveDream DHEA Or Pregnenolone To Combat Possible Caffeine-induced Stress? Ask For Help or Advice 9
S Other Things Like Caffeine To Try? Caffeine 3
J Mixing Caffeine, Aspirin, & Antihistamine Experiments 6
ecstatichamster Caffeine Lowers Cerebral Blood Flow Scientific Studies 7
E New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson's Disease Scientific Studies 2
Mito New Evidence That Higher Caffeine And Urate Levels Are Protective Against Parkinson’s Articles & Scientific Studies 0
Tristan Loscha Caffeine Decreases Vitamin D Receptor Protein Expression In Vitro D 0
Kingpinguin How Do People Handle Caffeine? Coffee 34
Hgreen56 Caffeine Cause Joint Pain/inflammation Supplements, Pharmaceutical Drugs 3
Hgreen56 Has Someone Positive Experience Lowering Cortisol With Caffeine? Supplements, Pharmaceutical Drugs 4
fitnessgirl Caffeine 3x300mg/day Safe? Supplements, Pharmaceutical Drugs 1
S.Seneff The Effects Of Caffeine On Lipid And Mineral Content In The Serum Of Rats Caffeine 6
maillol Caffeine Reduces Fatty Liver But Increases FFA Metabolism 32
J Caffeine Ask For Help or Advice 7
H How Does Caffeine Stop My Hairloss? Hair & Nails 2
S How To Take Caffeine Without Raising Blood Pressure Caffeine 22
E Is Caffeine Tolerance A Big Deal? Coffee 0
ScurveDream Re-introducing Caffeine Back In To My Diet . How Should I Do It? Diet 9
R Why Does Caffeine + Milk Do This To Me? Milk 8
methylenewhite Minocycline Lowers My Caffeine Tolerance Pharmaceutical Drugs 4

Similar threads

Top