NAD⁺ Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice

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  1. paymanz

    paymanz Member

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    NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. - PubMed - NCBI

    Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treatment with the NAD(+) precursor nicotinamide riboside (NR) induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated MuSCs in aged mice. NR also prevented MuSC senescence in the mdx (C57BL/10ScSn-Dmd(mdx)/J) mouse model of muscular dystrophy. We furthermore demonstrate that NR delays senescence of neural SCs and melanocyte SCs and increases mouse life span. Strategies that conserve cellular NAD(+) may reprogram dysfunctional SCs and improve life span in mammals.
     
  2. ecstatichamster

    ecstatichamster Member

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    strategies that conserve cellular NAD(+) -- what are some of them?
     
  3. OP
    paymanz

    paymanz Member

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    the most powerful tool is niacinamide supplementation.
     
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    paymanz

    paymanz Member

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