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nicotinamide
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Chronic pain due to mitochondrial dysfunction, niacinamide can treat it
As many of my readers know, there is an epidemic of chronic pain disorders in Western countries, which has subsequently led to over-prescription and (ab)use of opioid medication, which has then acted as a gateway drug and fueled a massive and deadly opioid epidemic in those countries. In order...- haidut
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- inflammation mitochondria niacinamide nicotinamide nicotinamide riboside pain vitamin b3
- Replies: 0
- Forum: Scientific Studies
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HUMAN STUDY: Vitamin B3 ups muscle/bone mass/strength, lowers fat, improves glucose control
The study is epidemiological and it did not distinguish between the various forms of vitamin B3 available through the diet or supplements. However, it was well-controlled and its findings match the known biochemical effects of vitamin B3, which the study authors cite themselves as the likely...- haidut
- Thread
- diabetes fat insulin muscle niacin niacinamide nicotinamide sarcopenia vitamin b3
- Replies: 13
- Forum: Scientific Studies
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HIV-1 Breakthrough: niacinamide as a possible treatment
The study does not claim a cure but it is a direct corroboration of human trials with HIV-1 patients conducted back in the early 1990, as those trials used high dose niacinamide (3g daily) and found improvement in the general condition of the patients. The mechanism of actions was, again...- haidut
- Thread
- aids hiv hiv-1 nad niacinamide nicotinamide nmn vitamin b3
- Replies: 1
- Forum: Scientific Studies
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Niacinamide may lower blood pressure in humans by raising NAD+
The study actually used the now-banned NAD+ precursor known as nicotinamide mononucleotide (NMN), but, as I keep reminding people, multiple studies have demonstrated statistically equivalent rise in NAD+ levels from equal doses of any of the known NAD+ precursors such as niacin, niacinamide...- haidut
- Thread
- cd38 cvd hypertension inflammation niacinamide nicotinamide nicotinamide mononucleotide vitamin b3
- Replies: 9
- Forum: Scientific Studies
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Human trial - niacinamide may treat Alzheimer Disease (AD)
One of my first posts on the topic of bioenergetics - more than a decade ago - was in regards to a promising animal study with the human-equivalent dose (HED) of 30mg/kg niacinamide (NAM) daily showing robust effects on that animal species' model of AD. The authors of the animal study followed...- haidut
- Thread
- alzheimer dementia nad niacinamide nicotinamide oxphos
- Replies: 8
- Forum: Scientific Studies
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NAD+ deficiency causes kidney disease, niacinamide prevents it
Chronic kidney disease (CKD) is one of the most prevalent complications of obesity and diabetes. Its causes, as usual, are "unknown" according to mainstream medicine but high glucose levels and genetic predisposition are thought to play a role. Many studies have called into question these...- haidut
- Thread
- ckd kidney nad niacinamide nicotinamide nmn nr oxphos
- Replies: 2
- Forum: Scientific Studies
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Niacinamide may prevent neurodegeneration
Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...- haidut
- Thread
- autophagy nad neurodegeneration niacinamide nicotinamide parp sirtuin vitamin b3
- Replies: 6
- Forum: Scientific Studies
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Niacinamide/NAD+ may prevent heart failure
The rates of cardiovascular disease (CVD) continue to rise and the condition is still the top killer in developed countries, though it is likely that cancer will take the top spot in the next few years and CVD will move back to second place. Heart failure (HF) is one of the common outcomes of...- haidut
- Thread
- fibrosis heart failure nad niacinamide nicotinamide oxphos
- Replies: 0
- Forum: Scientific Studies
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Niacinamide fully reverses endotoxemia and leaky gut (from ethanol)
The study below is a true gem due to both its broadness of impact, as well as the ease and low-cost of the therapeutic intervention it studied. Chronic endotoxemia, a cause and a result of increased gut permeability (aka "leaky gut") is now known to be a major cause of virtually all chronic...- haidut
- Thread
- alcohol atp endotoxin ethanol leaky gut lps nad niacinamide nicotinamide
- Replies: 21
- Forum: Scientific Studies
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A single, low dose niacinamide drops triglycerides by 75%
Among the vitamin B3 analogs, niacin is perhaps the most famous for its ability to both raise "good" cholesterol (HDL) and also lower triglycerides. However, niacinamide, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are all effective precursors to NAD (as niacin is) and...- haidut
- Thread
- lipolysis nad niacinamide nicotinamide nmn triglycerides vitamin b3
- Replies: 17
- Forum: Scientific Studies
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Niacinamide increases ATP/NAD, lower glucose/cortisol in humans
A great new study demonstrating for the first time in a human experiment what hundreds of animal studies had suggested in the past. Namely, that niacinamide can serve as a reliable precursor to NAD+ and by raising the NAD/NADH ratio results in improved glucose metabolism and higher ATP levels...- haidut
- Thread
- atp cortisol glucose insulin nad niacinamide nicotinamide ribose
- Replies: 18
- Forum: Scientific Studies
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Low-dose niacinamide has striking anti-obesity effects
It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...- haidut
- Thread
- co2 nad nampt niacinamide nicotinamide obesity oxphos vitamin b3
- Replies: 189
- Forum: Scientific Studies
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Age-related steroid deficiency may be treatable with niacinamide
The study is actually about eye health, and the effects androgens play in it. However, the findings are not limited to the eyes and are in fact applicable for any other tissue/organ experiencing a decline in steroidogenesis with advancing age, which is basically all of them. As such, I am...- haidut
- Thread
- aging androgen dry eye eye hypogonadism meibomian nad niacinamide nicotinamide nicotinamide mononucleotide nicotinamide riboside nmn nr steroidogenesis
- Replies: 15
- Forum: Scientific Studies
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Niacinamide increases aerobic capacity, muscle endurance in humans
There has been a steady increase in human studies with vitamin B3 analogs over the last 3-5 years. Most of that human research is sponsored by the company ChromaDex, which sells a proprietary formulation of nicotinamide riboside (NR), despite its own studies demonstrating that niacinamide /...- haidut
- Thread
- aerobic capacity endurance muscle niacinamide nicotinamide nicotinamide mononucleotide nmn oxygen update vitamin b3
- Replies: 9
- Forum: Scientific Studies
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Niacinamide may treat ALS by improving energetic state
Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...- haidut
- Thread
- als atp glycolysis lactate niacinamide nicotinamide oxphos vitamin b3 warburg
- Replies: 0
- Forum: Scientific Studies
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Niacinamide may treat depression by improving energetic state
A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...- haidut
- Thread
- atp depression fao fatty acid oxidation niainamide nicotinamide sirt1 vitamin b3
- Replies: 11
- Forum: Scientific Studies