1. Mauritio

    Microdosing nicotine increases NAD levels and rejuvenates old mice

    This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...
  2. haidut

    Low-dose niacinamide has striking anti-obesity effects

    It looks like the medical world has firmly set its sights on the bioenergetic wave/target, as the number of scientific papers focusing on niacinamide, NAD/NADH ratio and OXPHOS in general has been steadily climbing since 2010. That would be good news, despite the attempts of companies such as...
  3. haidut

    Niacinamide May Treat ALS (and Stroke)

    I posted a few studies in the past demonstrating that ALS is a mitochondrial/metabolic disease and as such can be treated with pro-metabolic therapies like thyroid or copper (currently in clinical trials). This new study shows that raising NAD levels with the NAD precursor nicotinamide...