Is trimethylaminuria toxic?

[Ippodrom47]

According to:

Trimethylaminuria ('fish odour syndrome')

Read more about trimethylaminuria which is an uncommon genetic disorder that causes a strong body odour, usually described as like rotting fish, poo or rubbish.

www.nhs.uk

In trimethylaminuria, the body is unable to turn a strong-smelling chemical called trimethylamine – produced in the gut when bacteria break down certain foods – into a different chemical that doesn't smell.

This means trimethylamine builds up in the body and gets into bodily fluids like sweat.

Is trimethylamine toxic by itself to the body?

 

[cedric]

TMAO and Red Meat - What is it and is it Harmful | Chris Kresser

A recent study proposed a link between red meat consumption and an increase of TMAO in the bloodstream But how accurate is this claim? Read on for more.

chriskresser.com

" Is TMAO the new cholesterol? Find out why red meat is still innocent."

Is problem of TMAO associated wit B2 deficiency? Prof. R.Peat said that B2 deficiency could be the most common.

Choline

Contents Summary Function Structural integrity of cell membranes Cell signaling Nerve impulse transmission Lipid transport and metabolism Source of methyl groups Osmoregulation Defi

lpi.oregonstate.edu

" Safety

Toxicity​

High doses (10,000 to 16,000 mg/day) of choline have been associated with a fishy body odor, vomiting, salivation, and increased sweating. The fishy body odor results from excessive production and excretion of trimethylamine, a metabolite of choline. In the inherited condition, primary trimethylaminuria (also known as “fish odor syndrome”; see the article on Riboflavin), a defective flavin containing monooxygenase 3 (FMO3) enzyme results in impaired oxidation of trimethylamine in the liver. Disease management includes the use of choline-restricted diets in affected individuals (81)."

https://pharmacistben.com/nutrition/choline-is-a-stabilizing-force/

" This transition from the watery milieu inside a cell through the oily cell covering and into the outer cellular environment is regulated and facilitated by the chemical components of the membrane. And, of these chemical components, which include fats and proteins, none is more important than choline, a molecule that can have BOTH watery and fatty properties. This ambidextrous nature makes choline an ideal molecule for the membrane transition area.

Choline thus acts like a stabilizing force that allows the membrane to segregate the inside world of a cell from the outside environment it’s sitting in. In this way choline can be considered to be a converting chemical that can connect and transform the energetics, the energy activity of water molecules which have has a particular type of structural pattern (scientists call it polar) to the energy activity of oil which from a molecular standpoint is more like an unstructured straight line (scientists call it non-polar)."