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https://www.researchgate.net/public...lorine_Pesticides_Blood_Urine_and_Sweat_Study
"Due to the ability of OCPs to accumulate in body tissues, their long half-life of elimination from the body, and emerging evidence of potential toxicity to human health, many countries throughout the world went on to ban many of the agents within the OCP family [4]. The sequelae of the OCP experiment, however, continue to linger as human contamination with these chemical compounds is still evident throughout the globe."
"as persistent organochlorine compounds have been associated with myriad health risks, it might be possible to diminish the risk of adverse health sequelae and transgenerational spread of OCPs if means were identified to facilitate elimination of these agents from the human body altogether."
"OCPs are lipophilic contact insecticides; they have low vapour pressures and slow rates of environmental degradation. These properties make them highly penetrable, long lasting, and extremely effective pesticide agents [13]. These properties also contribute to bioaccumulation within the human organism by the ready absorption into the body and subsequent deposition into adipose tissue."
"To date, it has been realized that organochlorine insecticides exert pathobiological impact including carcinogenicity, neurotoxicity, hormone disruption, and other toxic effects [5, 23–28]. Some studies have linked OCP exposure to significantly higher rates of cancers of the breast, liver, testicles, and lung, as well as sarcoma and non-Hodgkin’s lymphoma [26, 29]. OCP exposure has also been linked to higher rates of endometriosis in women [28] and increased risk for diabetes and obesity [30–32], as well as higher risk for neurological disorders like Parkinson’s disease [33, 34]. Studies with children and adolescents have linked OCP exposure to neurological and psychiatric sequelae including abnormal reflexes, reduced cognitive development, depression, and behavioral problems [35]."
"Although designed as acute neurotoxins, OCPs have been found to dysregulate human metabolic processes through several different pathways. These pathophysiological mechanisms include mitochondrial damage [24, 36], oxidative stress [37], cell death [38], endocrine disruption [39], and epigenetic modification [40, 41]. As discussed, there is also evidence that concomitant contamination with OCPs along with other toxic chemical agents may exhibit synergistic effects [15]."
"As DDT, DDE, DDD, methoxychlor, endosulfan sulfate, and endrin appear to be readily excreted into sweat, induced perspiration appears to be a potential clinical tool to diminish the body burden of these agents. With the exception of DDE, however, these agents are not readily detected in blood testing. This suggests that common blood analysis may not truly represent the body burden of these compounds. As the routine use of unprovoked blood testing may thus be inadequate for biomonitoring body burdens of OCPs, there may be clinical advantages to the induction of perspiration through methods like sauna and/or exercise in order to collect samples for biomonitoring and diagnosis of many retained OCP compounds.
In conclusion, the previous four papers in this "blood, urine, and sweat (BUS)" series have demonstrated that induced perspiration is effective at facilitating the removal of many toxic elements as well as various organic compounds, but not all [59–62]. This OCP study provides evidence that transdermal depuration through perspiration facilitates elimination of some parent and metabolite OCP compounds, but not all. While the absolute amount of each OCP compound released into sweat may be small according to this data, an average adult may sweat more than one liter per hour during exercise. Under thermal stress, maximal rates of sweating may be as high as two to four liters/hour [63]; and sweating rates for "acclimatized" people who regularly use [infrared] saunas may be as high as two liters/hour [64]. Accordingly, regular sessions of induced perspiration should be considered cumulatively as a potential clinical modality to diminishbody burdens of many xenobiotics, including OCP compounds.
Additional Points
Key Findings
(a) DDT and/or its metabolite(s) were found in nearly every participant regardless of age suggesting that exposure is very common.
(b) Nearly all organochlorine pesticide (OCP) parent compounds and several metabolites were detected in perspiration suggesting that sweating may be efficacious in diminishing the body burden of many of these toxicants.
(c) There were some parent OCPs, such as endosulfan I and hexachlorobenzene, and some metabolites, such as endrin ketone and heptachlor, that were not readily excreted into perspiration.
(d) Lipophilicity appeared to be a major factor influencing the efficacy of transdermal OCP elimination but not the exclusive determinant.
(e) Only endosulfan I appeared to be predominantly detected in urine suggesting that urine analysis has limited value in detection of retained OCPs.
(f) burtlancast is gifted"
How to do it.
"Due to the ability of OCPs to accumulate in body tissues, their long half-life of elimination from the body, and emerging evidence of potential toxicity to human health, many countries throughout the world went on to ban many of the agents within the OCP family [4]. The sequelae of the OCP experiment, however, continue to linger as human contamination with these chemical compounds is still evident throughout the globe."
"as persistent organochlorine compounds have been associated with myriad health risks, it might be possible to diminish the risk of adverse health sequelae and transgenerational spread of OCPs if means were identified to facilitate elimination of these agents from the human body altogether."
"OCPs are lipophilic contact insecticides; they have low vapour pressures and slow rates of environmental degradation. These properties make them highly penetrable, long lasting, and extremely effective pesticide agents [13]. These properties also contribute to bioaccumulation within the human organism by the ready absorption into the body and subsequent deposition into adipose tissue."
"To date, it has been realized that organochlorine insecticides exert pathobiological impact including carcinogenicity, neurotoxicity, hormone disruption, and other toxic effects [5, 23–28]. Some studies have linked OCP exposure to significantly higher rates of cancers of the breast, liver, testicles, and lung, as well as sarcoma and non-Hodgkin’s lymphoma [26, 29]. OCP exposure has also been linked to higher rates of endometriosis in women [28] and increased risk for diabetes and obesity [30–32], as well as higher risk for neurological disorders like Parkinson’s disease [33, 34]. Studies with children and adolescents have linked OCP exposure to neurological and psychiatric sequelae including abnormal reflexes, reduced cognitive development, depression, and behavioral problems [35]."
"Although designed as acute neurotoxins, OCPs have been found to dysregulate human metabolic processes through several different pathways. These pathophysiological mechanisms include mitochondrial damage [24, 36], oxidative stress [37], cell death [38], endocrine disruption [39], and epigenetic modification [40, 41]. As discussed, there is also evidence that concomitant contamination with OCPs along with other toxic chemical agents may exhibit synergistic effects [15]."
"As DDT, DDE, DDD, methoxychlor, endosulfan sulfate, and endrin appear to be readily excreted into sweat, induced perspiration appears to be a potential clinical tool to diminish the body burden of these agents. With the exception of DDE, however, these agents are not readily detected in blood testing. This suggests that common blood analysis may not truly represent the body burden of these compounds. As the routine use of unprovoked blood testing may thus be inadequate for biomonitoring body burdens of OCPs, there may be clinical advantages to the induction of perspiration through methods like sauna and/or exercise in order to collect samples for biomonitoring and diagnosis of many retained OCP compounds.
In conclusion, the previous four papers in this "blood, urine, and sweat (BUS)" series have demonstrated that induced perspiration is effective at facilitating the removal of many toxic elements as well as various organic compounds, but not all [59–62]. This OCP study provides evidence that transdermal depuration through perspiration facilitates elimination of some parent and metabolite OCP compounds, but not all. While the absolute amount of each OCP compound released into sweat may be small according to this data, an average adult may sweat more than one liter per hour during exercise. Under thermal stress, maximal rates of sweating may be as high as two to four liters/hour [63]; and sweating rates for "acclimatized" people who regularly use [infrared] saunas may be as high as two liters/hour [64]. Accordingly, regular sessions of induced perspiration should be considered cumulatively as a potential clinical modality to diminishbody burdens of many xenobiotics, including OCP compounds.
Additional Points
Key Findings
(a) DDT and/or its metabolite(s) were found in nearly every participant regardless of age suggesting that exposure is very common.
(b) Nearly all organochlorine pesticide (OCP) parent compounds and several metabolites were detected in perspiration suggesting that sweating may be efficacious in diminishing the body burden of many of these toxicants.
(c) There were some parent OCPs, such as endosulfan I and hexachlorobenzene, and some metabolites, such as endrin ketone and heptachlor, that were not readily excreted into perspiration.
(d) Lipophilicity appeared to be a major factor influencing the efficacy of transdermal OCP elimination but not the exclusive determinant.
(e) Only endosulfan I appeared to be predominantly detected in urine suggesting that urine analysis has limited value in detection of retained OCPs.
(f) burtlancast is gifted"
How to do it.
