Iron Deficiency May Protect Against Malaria, TB And Cancer

Discussion in 'Toxins, Detoxification' started by messtafarian, Nov 26, 2014.

  1. messtafarian

    messtafarian Member

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    I was just doing a little Googlefu about iron stores since my iron binding capacity is really high, trying to decide if I should supplement or not. I keep thinking I probably should not, especially if I happen to actually be sick.

    Then I ran across this:

    Iron deficiency, even mild anemia, may protect against malaria, TB and cancer
    By Marta Zaraska November 24, 2104


    If you’ve got anemia, that might be good news.

    Does such a statement sound weird to you? That’s to be expected: For years we’ve been told that anemia and iron deficiency are nothing short of evil. They should be treated as soon as possible, with any means possible: hence the 108-milligram iron pills sold in many pharmacies.

    Yes, it is true that anemia can be a crippling condition and that, when severe, it can cause heart failure. But a growing pile of clinical evidence shows that low iron stores and mild anemia may be beneficial in some cases, by offering protection from infections such as malaria and tuberculosis, and by helping combat chronic diseases including cancer.

    “Anemia is a body’s genetically programmed response to illness. You can [see this effect] in many animals, even fish,” says Ryan Zarychanski, a University of Manitoba physician and scientist who researches the adaptive and helpful aspects of iron deficiency and anemia.

    The terms “iron deficiency” and “anemia” are sometimes used interchangeably, but the two conditions are slightly different. With iron deficiency, the body does not have enough iron, which helps make red blood cells. (It can be present without anemia, if the iron stores are not too severely depleted.) Anemia, on the other hand, is a condition in which either the number of red blood cells is too low or those blood cells don’t have enough hemoglobin, a protein that helps move oxygen from the lungs to other parts of the body.

    While iron deficiency anemia is the most common type of the condition, anemia can have many causes, including genetic disorders, a shortage of vitamin B12 or folic acid, infection and cancer. According to the World Health Organization, iron deficiency anemia affects about a billion people across the planet.


    Blocking the bacteria

    How can iron deficiency, and even consequent anemia, protect us from infections? “With rare exception, bacteria need iron to grow,” Zarychanski explains. “If you take away the iron, the bacteria can’t multiply, which means your body can more easily overcome illness, especially infection.”

    This was most famously hinted at in 2003, in a large trial of iron supplementation for children in Tanzania. The study was halted early because the kids who had been given iron supplements developed a much higher risk of severe malaria than those given a placebo. As a result, the World Health Organization stopped recommending universal iron supplementation for children in malaria-endemic areas. According to Hal Drakesmith, a molecular immunologist at the University of Oxford who studies the role of iron in human immunity but was not connected to this study: “There is now pretty good evidence that iron deficiency could protect against severe malaria in children.”

    Studies have also suggested that iron can make tuberculosis worse. A lab experiment conducted in 2005 showed that giving mice iron-removing compounds limited the growth of the TB-causing bacteria. In other trials, people with tuberculosis fared worse when they received iron supplements.

    Meanwhile, a 2007 investigation in Gambia demonstrated that elevated levels of iron were associated with a higher rate of death in people with HIV infection, while a 2013 study showed that children given iron to reduce anemia were more likely than others to develop diarrhea and respiratory conditions.

    According to Zarychanski, iron deficiency is our “innate antimicrobial strategy.” Once infected, humans appear to be programmed to reduce production of iron so that bacteria or viruses don’t have enough of this nutrient to grow.

    Scientists speculate that this may have helped our ancestors survive epidemics. Even in an era of antibiotics, such a strategy may still be useful, especially where pathogens are abundant and health care is poor. “There is evidence that low-iron states or even anemia could be beneficial in a setting where there is a big burden of infectious disease,” Drakesmith says.

    In addition, when too much iron enters a human body, the delicate balance of bacteria in the gut can be upset. As Drakesmith explains, lactobacilli, one of the “good” bugs that help digestion, don’t require iron to grow, while the “bad” ones, such as salmonella and E.coli, do need it to grow.


    Iron overload

    In states of iron overload — which can be caused by diet, taking supplements or from genetic disorders — pathogenic bacteria can multiply and overwhelm the protective ones. A study of Kenyan infants published this year showed that iron fortification can result in considerably more diarrhea. Beyond that, says Suzy Torti, a professor of molecular biology at the University of Connecticut, “in a local environment such as the gut that sees iron every day, excessive intake may increase cancer risk.” She adds that “there is now a pretty convincing body of literature” connecting high intake of dietary iron with colon cancer. Not only does iron damage DNA by promoting oxidative stress — a disturbance in the balance between free radicals and antioxidants, which can cause cancer — it also stimulates the growth of tumors once they have begun, studies suggest.

    Zarychanski suggests that anemia that commonly accompanies severe conditions such as cancer, heart disease and autoimmune disorders is an adaptive physiologic mechanism that helps us fight illness. In three separate studies, transfusing blood to treat anemia was found to cause more harm than good. Patients with myocardial infarction, for example, were more likely to have another heart attack within 30 days.

    On the flip side, a 2008 clinical trial showed that bloodletting — which reduces iron stores — decreased cancer risk among otherwise healthy people with peripheral arterial disease.

    Does that mean the medieval cure of bloodletting to combat illness wasn’t completely misguided? “I’ve often thought there was something in there,” admits Torti, adding that the potential utility of such a treatment depends on when, how and to whom it is administered.

    Researchers say that future treatments for some diseases may involve using the iron hunger of pathogens and cancer cells against them. “Bacteria can become resistant to antibiotics, but what they can’t do is avoid their need for iron to grow,” Drakesmith says. “This is potentially another way of attacking them. Even if a minor iron deficiency develops, that wouldn’t be too bad if it really helps to slow down the infection.”

    A 2008 study conducted on mice showed that iron chelators (compounds that remove iron from the body) limited the growth of bacteria. Similar treatment may be beneficial in cancer. “Targeted iron-depleting agents that could get to tumors and withdraw the iron from them could have a therapeutic potential,” Torti says.
     
  2. Birdie

    Birdie Member

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    Excellent. This goes along with what Peat has been saying about neglected research and info on iron. Thanks for posting.
     
  3. jyb

    jyb Member

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    I don't understand the mechanism well, how a bit less iron would feed less bacteria. If I have an infection, say sore throat, there is bacteria on the outside (not in blood circulation). Are those bacteria really so sensitive to some lesser concentration of iron on the other side of the wall?

    I would have thought that the explanation is simpler that more iron (if more than a threshold) means weaker health and immune system.
     
  4. Birdie

    Birdie Member

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    Ray Peat on iron:


    Q: You believe iron is a deadly substance. Why?

    Iron is a potentially toxic heavy metal. In excess, it can cause cancer, heart disease, and other illnesses.
    Q: Could you tell us about some of these studies?

    In the 1960s the World Health Organization found that when iron supplements were given to anemic people in Africa, there was a great increase in the death rate from infectious diseases, especially malaria. Around the same time, research began to show that the regulation of iron is a central function of the immune system, and that this seems to have evolved because iron is a basic requirement for the survival and growth of cells of all types, including bacteria, parasites, and cancer. The pioneer researcher in the role of iron in immunity believed that an excess of dietary iron contributed to the development of leukemia and lymphatic cancers. Just like lead, mercury, cadmium, nickel and other heavy metals, stored iron produces destructive free radicals. The harmful effects of iron-produced free radicals are practically indistinguishable from those caused by exposure to X-rays and gamma rays; both accelerate the accumulation of age-pigment and other signs of aging. Excess iron is a crucial element in the transformation of stress into tissue damage by free radicals.

    For about 50 years, it has been known that blood transfusions damage immunity, and excess iron has been suspected to be one of the causes for this. People who regularly donate blood, on the other hand, have often been found to be healthier than non-donors, and healthier than they were before they began donating.

    In one of Hans Selye's pioneering studies, he found that he could experimentally produce a form of scleroderma (hardening of the skin) in animals by administering large doses of iron, followed by a minor stress. He could prevent the development of the condition by giving the animals large doses of vitamin E, suggesting that the condition was produced by iron's oxidative actions.

    Excess iron's role in infectious diseases is now well established, and many recent studies show that it is involved in degenerative brain diseases, such as Parkinson's, ALS (Lou Gehrig's disease), Huntington's chorea, and Alzheimer's disease. Iron is now believed to have a role in skin aging, atherosclerosis, and cataracts of the lenses of the eyes, largely through its formation of the "age pigment
     
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