What about those (like myself) with a GSTP1/rs1695 mutation that results in vitamin E increasing inflammation/IL-6? Apparently, it's common.By inhibiting lipid peroxidation and lowering inflammation, thus protecting the leydig cells.
It also potently lower estrogen and prolactin which will help to increase T.
Vit E also increases the sensitivity to LH and vit e deficient leydig cells have a reduced cAMP response, thus less T is produced.
For dose, it depends on how much PUFAs you're eating as well as how much PUFAs are in your system.
400-800IU should be more than enough to increase T and lower estrogen and prolactin.
I haven't done labs while using vit E.
Variants in the genes encoding TNF-α, IL-10, and GSTP1 influence the effect of α-tocopherol on inflammatory cell responses in healthy men